Blanca Fuentes
A5031771006- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Mesenchymal stem cell research
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Health and Disease Prevention
- Extracellular vesicles in disease
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular and Diving-Related Complications
- COVID-19 Clinical Research Studies
- Moyamoya disease diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology of Language and Bilingualism
- Neurological and metabolic disorders
- Cardiac Arrhythmias and Treatments
- Peripheral Artery Disease Management
Universidad Autónoma de Madrid
2016-2025
Hospital Universitario La Paz
2016-2025
Hospital La Paz Institute for Health Research
2015-2025
Universidad Carlos III de Madrid
2023
University of Thessaly
2016-2022
Hospital de Egas Moniz
2022
Boston University
2022
Boston Medical Center
2022
Stroke Association
2021
Neurology, Inc
2021
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Stem cell therapy can promote good recovery from stroke. Several studies have demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more information regarding appropriate type is needed animal model. This study was targeted at analyzing the effects in ischemic stroke of acute intravenous (i.v.) administration allogenic bone marrow- (BM-MSC) adipose-derived-stem (AD-MSC) on functional evaluation results brain repair markers.Allogenic MSC (2 × 106 cells) were...
Abstract Mesenchymal stem cells have previously been shown to mediate brain repair after stroke; they secrete 50–100 nm complexes called extracellular vesicles (EVs), which could be responsible for provoking neurovascular and functional recovery. EVs observed by electron microscopy NanoSight, contain associated proteins such as CD81 Alix. This purified, homogeneous population of was administered intravenously subcortical stroke in rats. To evaluate the effects, we studied biodistribution,...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, level associated poor outcome unknown. Our objectives were to establish capillary glucose threshold highest predictive accuracy and evaluate its hypothetical value influencing functional by adjusting for other well-known factors stroke.The authors conducted a multicenter, prospective, observational cohort study 476 stroke within less than 24 hours from onset....
<b><i>Background:</i></b> In Spain, stroke is a major public health concern, but large population-based studies are scarce and date from the 1990s. We estimated incidence in-hospital mortality of through multicentered register in 5 geographical areas i.e. Lugo, Almería, Segovia, Talavera de la Reina Mallorca, representing north, south, central (×2) Mediterranean respectively, aim novelty being that all methodologies were standardized, diagnoses verified by neurologist...
Translational research is beginning to reveal the importance of trophic factors as a therapy for cellular brain repair. The purpose this study was analyze whether brain-derived neurotrophic factor (BDNF) administration could mediate oligodendrogenesis and remyelination after white matter injury in subcortical stroke.Ischemia induced rats by injection endothelin-1. At 24 hours, 0.4 μg/kg BDNF or saline intravenously administered treatment control groups, respectively. Functional evaluation,...
Acute ischemic stroke is currently a major cause of disability despite improvement in recanalization therapies. Stem cells represent promising innovative strategy focused on reduction neurologic sequelae by enhancement brain plasticity. We performed phase IIa, randomized, double-blind, placebo-controlled, single-center, pilot clinical trial. Patients aged ≥60 years with moderate to severe (National Institutes Health Stroke Scale [NIHSS] 8–20) were randomized (1:1) receive intravenous adipose...
The European Stroke Organisation (ESO) guidelines on Moyamoya Angiopathy (MMA), developed according to ESO standard operating procedure and Grading of Recommendations, Assessment, Development Evaluation (GRADE) methodology, were compiled assist clinicians in managing patients with MMA their decision making. A working group involving neurologists, neurosurgeons, a geneticist methodologists identified nine relevant clinical questions, performed systematic literature reviews and, whenever...
BackgroundLong-term data showing the benefits of endovascular thrombectomy for stroke with large infarct are scarce. The TENSION trial showed safety and efficacy in patients ischaemic at 90 days. We aimed to investigate 12 months who were enrolled trial.MethodsTENSION was an open-label, blinded endpoint, randomised done 40 hospitals across Europe one hospital Canada. included (aged ≥18 years) acute due vessel occlusion anterior circulation had a infarct, as indicated by Alberta Stroke...
The risk of stroke recurrence in patients with Embolic Stroke Undetermined Source (ESUS) is high, and the optimal antithrombotic strategy for secondary prevention unclear. We investigated whether congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, or transient ischemic attack (TIA; CHADS2) CHA2DS2-VASc scores can stratify long-term stroke/TIA death ESUS.We pooled data sets 11 registries from Europe America. ESUS was defined according to Cryptogenic Stroke/ESUS...
Rat adipose tissue-derived-mesenchymal stem cells (rAD-MSCs) have proven to be safe in experimental animal models of stroke. However, order use human AD-MSCs (hAD-MSCs) as a treatment for stroke patients, proof concept is needed. We analyzed whether the xenogeneic hAD-MSCs were and effective allogeneic rAD-MSCs permanent Middle Cerebral Artery Occlusion (pMCAO) rats. Sprague–Dawley rats randomly divided into three groups, which intravenously injected with (2 × 106), 106) or saline (control)...
The complexity of endovascular revascularization treatment (ERT) in acute ischemic stroke and the small number patients eligible for justify development center networks with interhospital patient transfers. However, this approach might result futile transfers (ie, transfer who ultimately do not undergo ERT). Our aim was to analyze frequency these reasons discarding ERT identify possible associated factors.We analyzed an observational prospective registry from a collaboration network...
Abstract Background Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy animal models stroke using a dose 100 μg. However, whether EVs is related to outcomes not known. This study aimed identify optimal effective from adipose tissue-derived mesenchymal cells that promote functional recovery subcortical stroke. Materials and methods For this purpose, various doses were tested an vitro oxygen-glucose...
Background and Purpose: The coronavirus disease 2019 (COVID-19) outbreak has added challenges to providing quality acute stroke care due the reallocation of resources COVID-19. Case series suggest that patients with COVID-19 have more severe strokes; however, no large compared outcomes contemporary non–COVID-19 patients. Purpose was analyze impact pandemic in evaluate according diagnosis Methods: Retrospective multicenter cohort study including consecutive admitted 7 centers from February 25...
Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course unpredictable. Finding biomarkers that help to better comprehend the disease's pathogenesis crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types contain information on pathological processes.To identify immune and system-derived EV profile from blood could have a specific role as biomarker in MS assess its possible...
Several clinical scales have been developed for predicting stroke recurrence. These scores could be extremely useful to guide triage decisions. Our goal was compare the very early predictive accuracy of most relevant [age, blood pressure, features and duration symptoms (ABCD) score, ABCD diabetes (ABCD2) brain infarction on imaging ABCD2 prior TIA within 1 week index event (ABCD3) California Risk Score, Essen Stroke Score Prognosis Instrument II] in consecutive transient ischemic attack...