Background and Purpose— Studies on the relation between blood pressure (BP) stroke outcome have shown contradictory results. We explored association of systolic (SBP) diastolic (DBP) BP during acute with early neurological deterioration, infarct volume, outcome, mortality at 3 months. Methods— included 304 patients ischemic stroke. SBP DBP admission first day were average values all readings obtained in emergency department a 24-hour period after patient allocation unit. Results— A U-shaped...

<b><i>Objective:</i></b> To identify potential predictors of and factors associated with early neurologic deterioration (END) in primary intracerebral hemorrhage (ICH). <b><i>Methods:</i></b> Two hundred sixty-six patients spontaneous supratentorial ICH admitted within 12 hours stroke onset were investigated a multicenter, prospective study. Sixty-one clinical, biochemical, neuroimaging variables registered on admission, 37 clinical at 48 hours. The volumes the peripheral edema admission...

Pretreatment with statins has been shown to reduce brain injury in cerebral ischemia. In this controlled randomized study, we investigated the influence of statin pretreatment and its withdrawal on outcome acute ischemic stroke patients.From 215 patients admitted within 24 hours a hemispheric stroke, 89 chronic treatment were randomly assigned either for first 3 days after admission (n = 46) or immediately receive atorvastatin 20 mg/day 43). The primary event was death dependency (modified...

Background and Purpose— Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship between MMP-9 concentrations blood within 24 hours stroke onset subsequent HT infarction. Methods— We studied 250 patients a hemispheric ischemic 7.8±4.5 hours’ duration. Early CT signs infarction were evaluated on admission. The infarct volume analyzed from performed days 4...

<b><i>Background:</i></b> The mechanisms of cellular death in the tissue surrounding an intracerebral hemorrhage (ICH) are not defined. <b><i>Objective:</i></b> To investigate relationship markers excitotoxicity and inflammation to brain injury after ICH. <b><i>Methods:</i></b> A total 124 consecutive patients with spontaneous ICH admitted within 24 hours stroke onset were prospectively investigated. volumes initial ICH, peripheral edema on days 3 4, residual cavity at months measured CT...

Background and Purpose — The mechanisms underlying neurological deterioration in patients with lacunar infarction are not completely understood. In this study, we sought to investigate the role of proinflammatory molecules early worsening outcome acute stroke. Methods We performed a secondary analysis 113 consecutive included within first 24 hours onset symptoms previous study aimed at investigating clinical biochemical factors (END). END was defined as fall ≥1 points motor items Canadian...

To investigate whether molecular markers of inflammation and endothelial injury are associated with early growth intracerebral hemorrhage (ICH).In a multicenter prospective study, we determined concentrations interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-9 (MMP-9), cellular fibronectin (c-Fn) in blood samples obtained on admission from 183 patients primary hemispheric ICH <12 hours' duration. Patients had neurological evaluation computed tomography...

Increased circulating endothelial progenitor cells (EPC) have been associated with a low cardiovascular risk and may be involved in cell regeneration. The present study was designed to evaluate the prognostic value of EPC acute ischemic stroke.Forty-eight patients first-ever nonlacunar stroke were prospectively included within 12 hours symptoms onset. Stroke severity evaluated by National Institutes Health Scale, functional outcome assessed at 3 months modified Rankin Scale (mRS). Infarct...

<b><i>Objective:</i></b> To evaluate the usefulness of a mismatch between severity acute clinical manifestations and diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome infarct volume. <b><i>Methods:</i></b> One hundred sixty-six patients with hemispheric ischemic &lt;12 hours’ duration were studied. The NIH Stroke Scale (NIHSS) score volume DWI measured on admission at 72 ± 12 hours. Infarct was T2-weighted or fluid-attenuated inversion recovery images day 30. Early...

Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, level associated poor outcome unknown. Our objectives were to establish capillary glucose threshold highest predictive accuracy and evaluate its hypothetical value influencing functional by adjusting for other well-known factors stroke.The authors conducted a multicenter, prospective, observational cohort study 476 stroke within less than 24 hours from onset....

Stroke triggers an intense inflammatory response that could be a consequence of Toll-like receptors (TLRs) activation. However, the clinical significance and therapeutic possibilities TLR in stroke is not completely clear. In this study, we analyze association between expression TLR2 TLR4, molecules endogenous ligands, outcome ischemic patients, test potential TLR2/TLR4 their ligands as targets. For purpose, included 110 patients with finding TLR4 are independently associated to poor...

<h3>Objective:</h3> We aimed to study endothelial function with biochemical and ultrasonographic markers its relation progenitor cells (EPCs) in patients migraine. <h3>Methods:</h3> performed a case-control including 47 episodic migraine (International Headache Society 2004 criteria) 23 control subjects. analyzed flow-mediated dilation (FMD) the dominant brachial artery, calcitonin gene−related peptide (CGRP), vascular growth factor (VEGF) levels by ELISA, nitric oxide stable metabolites...

Elevated plasma levels of cellular fibronectin (c-Fn) reflect vascular damage, so c-Fn might be a marker secondary bleeding risk in cerebral ischemia. We investigated whether high were associated with hemorrhagic transformation (HT) after treatment tissue plasminogen activator (tPA) patients acute stroke.Eighty-seven (mean age: 67+/-12) received tPA the ECASS II criteria time to infusion: 160+/-46 minutes; median NIHSS: 12). HT and hypodensity volume studied on computed tomography (CT)...

Space-occupying brain edema is a life-threatening complication in patients with large hemispheric stroke. The aim of the study was to determine whether molecular markers endothelial damage may help predict secondary and, secondly, identify who could benefit from aggressive therapies such as decompressive hemicraniectomy or hypothermia.We studied 40 consecutive malignant middle cerebral artery (MCA) infarction and 35 controls massive MCA infarctions <70 years age matched by stroke severity on...

We evaluated the mortality and morbidity of acute cerebral infarction as related to modifiable factors: glucose level, temperature, hematocrit, hemoglobin platelet count. studied 177 patients with in territory middle artery, admitted within 24 h stroke onset. Blood was drawn on admission temperature recorded every 2 h, selecting highest during 1st day. Patient follow-up lasted 6 months. Barthel Index Neurological Score were at days 1, 4, 7, 14, 21 3 A Glasgow Scale administered Forty-five...

The capacity of the blood enzyme glutamate oxaloacetate transaminase (GOT) to remove from brain by means degradation has been shown in experimental models be an efficient and novel neuroprotective tool against ischemic stroke; however, beneficial effects this should tested patients with stroke validate these results. This study aims investigate association GOT levels clinical outcome acute stroke. In two independent studies, we found that poor show higher lower at time admission. Lower were...

OnabotulinumtoxinA is a treatment specifically approved for the prophylaxis of chronic migraine in adults. The aim this study was to assess effectiveness after 1 year real-life setting and identify clinical predictors outcome.We designed prospective multicentre performed 13 hospitals Spain. Patients underwent complete medical history examination. They were treated with every 12 weeks year. Data about outcome, adverse events, abortive medication use, emergency room use disability collected at...

To study iron deposition in red nucleus (RN), globus pallidus (GP), and periaqueductal gray matter (PAG) as a potential biomarker of chronic migraine (CM) its association with levels biomarkers related to pathophysiology.This case-control included 112 patients (55 CM, 57 episodic [EM]) 25 headache-free controls. We analyzed using 3T MRI the NIH software platform ImageJ; we serum markers inflammation, endothelial dysfunction, blood-brain barrier (BBB) disruption by ELISA peripheral blood...

Objective The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). Background OnabotA an effective chronic migraine (CM). Different studies have tried predictors response treatment, either clinical characteristics, neuroimaging features, or molecular biomarkers; however, it still not possible predict the individual outcome. Methods We measured serum levels inflammation (IL‐6, IL‐10, TNF‐α,...

A current hypothesis for migraine suggests that neuroexcitatory amino acids may participate in the triggering of attacks. To investigate this possibility we measured glutamic and aspartic acid level plasma cerebrospinal fluid (CSF) patients with common classic during attacks, making comparisons controls suffering from stress. Plasma levels were lower than controls. CSF concentrations higher migraineurs Our results suggest an excess CNS possibly favoring a state neuronal hyperexcitability.

Background and Purpose —The mechanisms involved in the neurological deterioration of acute lacunar strokes are unknown. Although accumulating evidence suggests that glutamate release plays a role progression territorial infarctions, it remains to be established whether excitotoxicity also participates stroke progression. We investigated excitatory inhibitory amino acid concentrations blood predict subsequent progressive motor deficits infarctions. Methods —We studied 113 consecutive patients...

BackgroundDepression is a frequent mood disorder that affects around 33% of stroke patients and has been associated with both poorer outcome increased mortality. Our aim was to test the possible association between inflammatory neurotrophic molecular markers development post-stroke depression.MethodWe studied 134 first episode ischemic without previous history depression or speech disorders. We screened for existence major symptoms in accordance DSM-IV criteria Yesavage Geriatric Depression...