Fabien Subtil
A5059137296- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Statistical Methods and Inference
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Frailty in Older Adults
- Colorectal Cancer Screening and Detection
- Lymphoma Diagnosis and Treatment
- Bayesian Methods and Mixture Models
- Health Systems, Economic Evaluations, Quality of Life
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Statistical Methods in Clinical Trials
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Statistical Methods and Bayesian Inference
- Ovarian cancer diagnosis and treatment
Centre National de la Recherche Scientifique
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Laboratoire de Biométrie et Biologie Evolutive
2016-2025
Hospices Civils de Lyon
2016-2025
Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
2019-2025
Hôpital Edouard Herriot
2024
Inserm
2017-2023
Hôpital Lyon Sud
2023
Centre de Recherche en Cancérologie de Lyon
2023
Lyon College
2008-2023
Elderly patients form a heterogeneous population. Evaluation of geriatric factors may help evaluate patient's health status to better adapt treatment.Elderly with previously untreated metastatic colorectal cancer (mCRC) were randomly assigned receive fluorouracil (FU) -based chemotherapy either alone or in combination irinotecan (IRI) the Fédération Francophone de Cancérologie Digestive (FFCD) 2001-02 study. Sites participating substudy completed screening tools perform prognostic factor...
OBJECTIVE Screening for advanced fibrosis (AF) resulting from metabolic dysfunction–associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of noninvasive tests (NITs) with that two-step algorithms detecting patients at high risk AF requiring referral hepatologists. RESEARCH DESIGN AND METHODS We conducted a planned interim analysis prospective multicenter including participants type 2 diabetes and/or obesity and MASLD...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
Background Longitudinal data are in which each variable is measured repeatedly over time. One possibility for the analysis of such to cluster them. The majority clustering methods group together individual that have close trajectories at given time points. These locally but not necessarily those similar shapes. However, several circumstances, progress a phenomenon may be more important than moment it occurs. would thus like achieve partitioning where gathers individuals whose shapes whatever...
TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered 100% PDAC cases. exerts complex and pleiotropic effects cancers, notably via activation SMAD pathways, predominantly SMAD2/3/4. Though SMAD2 3 are rarely mutated SMAD4 lost about 50% PDAC, role SMAD2/3 a SMAD4-null context remains understudied. We herein provide evidence oncogenic effect response to TGF-β1 human cancer cells. report that...
BackgroundLong-term data showing the benefits of endovascular thrombectomy for stroke with large infarct are scarce. The TENSION trial showed safety and efficacy in patients ischaemic at 90 days. We aimed to investigate 12 months who were enrolled trial.MethodsTENSION was an open-label, blinded endpoint, randomised done 40 hospitals across Europe one hospital Canada. included (aged ≥18 years) acute due vessel occlusion anterior circulation had a infarct, as indicated by Alberta Stroke...
Several previous studies have shown relationships between adherence to HIV antiretroviral therapy (ART) and the viral load, CD4 cell count, or mortality. However, impact of variability in ART on immunovirological response does not seem been investigated yet. Monthly data (November 1999 April 2009) from 317 HIV-1 infected patients enrolled Senegalese initiative were analyzed. Latent-class trajectory models used build typical trajectories for average standardized variance adherence. The...
First-line standard-of-care for unresectable, pleural mesothelioma (PM) changed with the phase 3 CheckMate 743 study results, showing that nivolumab plus ipilimumab (Nivo + Ipi) significantly extended overall survival (OS) versus platinum pemetrexed chemotherapy PM (median OS 18.1 14.1 months; hazard ratio: 0.74; p = 0.002). Efficacy and safety data in real-world (rw) settings are needed to confirm these results.
Abstract Background Endoscopic submucosal dissection (ESD) of residual or locally recurrent (RLR) colonic lesions after previous endoscopic mucosal resection (EMR) is an attractive but challenging technique. The present study aimed to evaluate the effectiveness and safety ESD with double clip rubber band traction (DCT-ESD) RLR lesions. Methods We retrospectively analyzed all consecutive DCT-ESD procedures for (rectum excluded) performed in two French centers. frequency en bloc R0 resections,...
Patients with systemic sclerosis and both pulmonary hypertension interstitial lung disease (SSc-PH-ILD) generally carry a worse prognosis than patients SSc arterial (SSc-PAH) without ILD. There is no evidence of the efficacy PAH therapies in SSc-PH-ILD. We undertook this study to compare survival response treatment SSc-PH-ILD those SSc-PAH.We analyzed 128 (66 62 SSc-PAH) from 15 centers, whom PH was diagnosed by right-sided heart catheterization; they were prospectively included registry....
In sub-Saharan Africa, men living with HIV often start ART at more advanced stages of disease and have higher early mortality than women. We investigated gender difference in long-term immune reconstitution.Antiretroviral-naïve adults who received for least 9 months four programs Africa were included. Multivariate mixed linear models used to examine differences reconstitution on first line ART. A total 21,708 patients (68% women) contributed 61,912 person-years follow-up. At start,. Median...
Per-oral endoscopic myotomy (POEM) is a recommended treatment modality for achalasia, but there little published data its use in children. The objective of the present study was to evaluate whether POEM clinically effective and safe children.International multicenter retrospective conducted 14 tertiary centers that included consecutive children who underwent between January 2012 August 2018. Outcomes, such as clinical response were assessed whenever available. Adverse events factors...
Historically, double or triple hit lymphoma (DHL and THL) have poor outcomes with conventional chemotherapy, but there is currently no guideline. We report the French experience in managing DHL THL first line using collective data on both survival tolerance. All consecutive patients newly diagnosis of large B-cell MYC, BCL2, and/or BCL6 rearrangements, as determined by FISH between January 2013 April 2019 were included. Based eligibility criteria, 160 selected among 184 identified. With a...
It is well known that thyroid dysfunction increases with age. This study aimed to determine reference intervals, in males and females, suitable for disease exploration during adult life using routinely collected serum thyrotropin (TSH) data a tertiary center from 2007 2018. Over 11 years, 295,775 TSH levels were measured single lab. Among the 156,025 results available analysis, 90,538 values female subjects, 82,019 patients aged >60 years 26,825 >80 years. By an indirect approach, we...
INTRODUCTION : Residual colorectal neoplasia (RCN) after previous endoscopic mucosal resection is a frequent challenge. Different management techniques are feasible including full-thickness using the device (FTRD) system and submucosal dissection (ESD). We aimed to compare efficacy safety of these two for treatment such lesions. METHODS All consecutive patients with RCN treated either FTRD or by ESD were retrospectively included in this multicenter study. The primary outcome was R0 rate,...
In an open-label multicenter non-randomized non-comparative phase II study in patients with stage IIIB/IV non-squamous non-small cell lung cancer (NSCLC), oncogenic addiction (EGFR mutation or ALK/ROS1 fusion), disease progression after tyrosine-kinase inhibitor and no prior chemotherapy (NCT04042558), atezolizumab, carboplatin, pemetrexed without bevacizumab showed some promising result. Beyond the clinical evaluation, we assessed safety patient-reported outcomes (PROs) to provide...