Susanne Gellißen
A5011642849- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Multiple Sclerosis Research Studies
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Peripheral Artery Disease Management
- Medical Imaging and Analysis
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Vascular Malformations Diagnosis and Treatment
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Case Reports on Hematomas
- Ultrasound and Hyperthermia Applications
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Bone and Joint Diseases
Universität Hamburg
2017-2025
University Medical Center Hamburg-Eppendorf
2017-2025
Klinik und Poliklinik für Neurologie
2018-2025
European Society of Clinical Microbiology and Infectious Diseases
2022
Eppendorf (Germany)
2018
Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since onset of symptoms was less than 4.5 hours. We sought determine whether patients with an unknown and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from use alteplase.
Purpose To investigate the feasibility of tumor type prediction with MRI radiomic image features different brain metastases in a multiclass machine learning approach for patients unknown primary lesion at time diagnosis. Materials and methods This single-center retrospective analysis included 658 from T1-weighted contrast material-enhanced, nonenhanced, fluid-attenuated inversion recovery (FLAIR) images 189 (101 women, 88 men; mean age, 61 years; age range, 32-85 years). Images were acquired...
Background and Purpose— Early selection of patients with acute middle cerebral artery infarction at risk for malignant edema is critical to initiate timely decompressive surgery. Net water uptake (NWU) per brain volume a quantitative imaging biomarker space-occupying ischemic which can be measured in computed tomography. We hypothesize that NWU early infarct lesions predict development edema. The aim was compare against other common predictors Methods— After consecutive screening...
Purpose Mechanical thrombectomy (MT) is a highly effective therapy in patients with acute ischemic stroke due to large vessel occlusion (LVO). However, complete recanalization of the occluded cannot be achieved all patients, leading poor clinical outcome. We analyzed reasons for failed help direct future improvements therapy. Methods 648 consecutive LVO and an MT attempt were retrospectively none or minimal recanalization, assessed according Thrombolysis Cerebral Infarction (TICI) score...
BackgroundLong-term data showing the benefits of endovascular thrombectomy for stroke with large infarct are scarce. The TENSION trial showed safety and efficacy in patients ischaemic at 90 days. We aimed to investigate 12 months who were enrolled trial.MethodsTENSION was an open-label, blinded endpoint, randomised done 40 hospitals across Europe one hospital Canada. included (aged ≥18 years) acute due vessel occlusion anterior circulation had a infarct, as indicated by Alberta Stroke...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
Prior reports on the location and sizes of brain metastases almost entirely focus patients with primary breast pulmonary cancer. This is first study comparing multiple other types cancer that metastasize to brain.This monocentric retrospective includes 369 untreated 3313 intraaxial metastases. Following semi-manual segmentation post-contrast T1WI, cumulative spatial probability distribution maps were created for whole group all tumors. Furthermore, mixed effects logistic regression model...
Myelin Water Fraction (MWF) measurements derived from quantitative Imaging (MWI) may detect demyelinating changes of the cerebral white matter (WM) microstructure. Here, we investigated age-related alterations MWF in normal aging brains healthy volunteers utilizing two fast and clinically feasible 3D gradient spin echo (GRASE) MWI sequences with 3 mm 5 isotropic voxel size. In 45 subjects (age range: 18-79 years), distinct regions interest (ROI) were defined WM including corticospinal...
BACKGROUND: Patient-specific factors associated with successful recanalization in mechanical thrombectomy (MT) have been evaluated for acute ischemic stroke large vessel occlusion. However, MT M2 occlusions is still a matter of debate, and predictors futile not assessed detail. We sought to identify success patients undergoing based on large-scale clinical data. METHODS: All prospectively enrolled the German Stroke Registry (May, 2015 December, 2021) were screened (N=13 082). Inclusion...
Infarct growth from the early ischemic core to total infarct lesion volume (LV) is often used as an outcome variable of treatment effects, but can be overestimated due vasogenic edema. The purpose this study was (1) assess two components by distinguishing between water uptake and true net (2) investigate potential effects on edema-corrected growth. Sixty-two M1-MCA-stroke patients with acute multimodal follow-up CT (FCT) were included. Ischemic calculated subtracting initial CTP-derived LV...
<h3>BACKGROUND AND PURPOSE:</h3> Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in stroke but should considered the context of location. In contrast to previous using ROI approach, which has several drawbacks, present study aimed measure impact location on more precise voxelwise approach. <h3>MATERIALS METHODS:</h3> Datasets patients with acute strokes from Multicenter Randomized Clinical Trial Endovascular Therapy Acute...
Objectives Final infarct volume is regularly used as an end point of tissue outcome in stroke trials; however, the reported volumes are most commonly derived from early follow-up imaging. Those significantly impaired by ischemic edema, which causes overestimation true final lesion volume. As net water uptake within brain can be quantified densitometrically computed tomography (CT) recently described, we hypothesized that better estimated correcting for corresponding proportion edema....
Background Flow diverters (FDs) have become an integral part of treatment for brain aneurysms. Aim To summarize available evidence factors associated with aneurysm occlusion (AO) after a FD. Methods References were identified using the Nested Knowledge AutoLit semi-automated review platform between January 1, 2008 and August 26, 2022. The focuses on preprocedural postprocedural AO in logistic regression analysis. Studies included if they met inclusion criteria study details (ie, design,...
Background and Purpose- The early growth of ischemic lesions has been described as being nonlinear, with lesion rates at their highest during the earliest period after stroke onset. We hypothesized that time gap from imaging to revascularization results in higher patients hyperacute presentation. Methods- Fifty-one initial multimodal computed tomography (CT), follow-up CT 24 hours, successful endovascular recanalization were included separated into 2 groups according median symptom onset...
Background and Purpose- Using a novel study design with virtual comparators based on predictive modeling, we investigated whether next-generation mechanical thrombectomy devices improve outcomes in patients ischemic stroke. We hypothesized that this new shows system is superior to intravenous tPA (tissue-type plasminogen activator) therapy (IVT) alone. Methods- ERASER (Eric Acute Stroke Recanalization) was an investigator-initiated, prospective, multicenter, single-arm (virtual 2-arm)...
Introduction In acute ischemic stroke, prediction of the tissue outcome after reperfusion can be used to identify patients that might benefit from mechanical thrombectomy (MT). The aim this work was develop a deep learning model predict follow-up infarct location and extent exclusively based on single-phase computed tomography angiography (CTA) datasets. comparison CT perfusion (CTP), CTA imaging is more widely available, less prone artifacts, established standard care in stroke protocols....
BACKGROUND: Recent randomized trials demonstrated the beneficial effect of endovascular therapy in patients with low Alberta Stroke Program Early Computed Tomography Score. Despite large follow-up infarct volumes, a significantly increased rate good functional outcomes was observed, challenging role volume as predictive imaging marker. This analysis evaluates extent to which effects thrombectomy on are explained by (1) and (2) early neurological status stroke METHODS: TENSION trial conducted...
In ischemic stroke, there is limited data regarding the impact of baseline hyperglycemia on treatment effect recanalization neurological recovery. This study aimed to directly compare-how short- and long-term serum glucose levels modify functional outcome in patients with stroke specifically analyze occurrence delayed recovery ("stunned brain phenomenon"). Observational retrospective analysis including anterior circulation large vessel occlusion undergoing mechanical thrombectomy following...
Introduction In recent years, numerous methods have been proposed to predict tissue outcome in acute stroke patients using machine learning incorporating multiparametric imaging data. Most include diffusion and perfusion parameters as image-based but do not any spatial information although these are spatially dependent, e.g. different properties white gray brain matter. This study aims investigate if including features improves the accuracy of multi-parametric prediction. Materials Acute...
Background Emerging data suggest that mechanical thrombectomy (MT) might also be safe and efficient for medium distal occlusions. This study aims to compare average treatment effects on functional outcome of different degrees recanalization after MT in patients with M2 occlusion M1 occlusion. Methods All enrolled the German Stroke Registry (GSR) between June 2015 December 2021 were analyzed. Inclusion criteria stroke primary or occlusion, availability relevant clinical data. 4259 included,...
Landmark thrombectomy trials have provided evidence that selected patients with large ischemic stroke benefit from successful endovascular therapy, commonly defined as incomplete (modified Thrombolysis In Cerebral Infarction (mTICI) 2b) or complete reperfusion (mTICI 3). We aimed to investigate whether mTICI 3 improves functional outcomes compared 2b in strokes.
Objective To investigate whether oral administration of a standardised frankincense extract (SFE) is safe and reduces disease activity in patients with relapsing-remitting multiple sclerosis (RRMS). Methods We performed an investigator-initiated, bicentric phase IIa, open-label, baseline-to-treatment pilot study SFE RRMS ( NCT01450124 ). After 4-month baseline observation phase, were treated for 8 months option to extend treatment up 36 months. The primary outcome measures the number volume...
Most false negative findings in DWI of ischemic stroke are patients with minor deficits clinically localized to the brainstem. Our goal was evaluate benefit a thin-sliced sagittal addition conventional axial at 1.5T for detection brainstem infarctions.Data symptoms consistent acute and subacute infarction an MRI examination including standard were retrospectively analyzed. Patients later diagnosis TIA, inflammation or tumor excluded from analysis. Diffusion restrictions identified by two...