A5007238841- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Advanced NMR Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Electron Spin Resonance Studies
- Atomic and Subatomic Physics Research
- Tryptophan and brain disorders
- MRI in cancer diagnosis
- Neuroscience and Neuropharmacology Research
- NMR spectroscopy and applications
- Lower Extremity Biomechanics and Pathologies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Fatty Acid Research and Health
- Veterinary Equine Medical Research
- Bipolar Disorder and Treatment
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Cancer-related molecular mechanisms research
University of Pennsylvania
2016-2025
Hospital of the University of Pennsylvania
1997-2025
United States Food and Drug Administration
2025
California University of Pennsylvania
2020-2024
Center for Food Safety and Applied Nutrition
2023
Government of the United States of America
2023
Dr. Reddy's Laboratories (India)
2023
Optica
2021
Resonance Research (United States)
2002-2020
Institute of Technology Management
2019
To quantify the spin-lattice relaxation time in rotating frame (T1rho) various clinical grades of human osteoarthritis (OA) cartilage specimens obtained from total knee replacement surgery, and to correlate T1rho with OA disease progression compare it transverse (T2).Human were consenting patients (N = 8) who underwent joint at Pennsylvania Hospital, Philadelphia, PA, USA. T2- T1rho-weighted images on a 4.0 Tesla whole-body GE Signa scanner (GEMS, Milwaukee, WI, USA). A 7-cm diameter...
Altered antioxidant status has been reported in schizophrenia. The glutathione (GSH) redox system is important for reducing oxidative stress. GSH, a radical scavenger, converted to oxidized (GSSG) through peroxidase (GPx), and back GSH by reductase (GR). Measurements of GSSG its related enzymatic reactions are thus evaluating the status. In present study, levels GSSG, GPx GR were assessed caudate region postmortem brains from schizophrenic patients control subjects (with without other...
In general, multiple components such as water direct saturation, magnetization transfer (MT), chemical exchange saturation (CEST) and aliphatic nuclear Overhauser effect (NOE) contribute to the Z ‐spectrum. The conventional CEST quantification method based on asymmetrical analysis may lead errors due semi‐solid MT asymmetry NOE located a single side of Fitting individual contributors ‐spectrum improve each component. this study, we aim characterize exchangeable from an intracranial tumor...
Soft bioelectronic interfaces for mapping and modulating excitable networks at high resolution large scale can enable paradigm-shifting diagnostics, monitoring, treatment strategies. Yet, current technologies largely rely on materials fabrication schemes that are expensive, do not scale, critically limit the maximum attainable coverage. Solution processing is a cost-effective manufacturing alternative, but biocompatible conductive inks matching performance of conventional metals lacking....
Abstract Proteoglycan (PG) depletion‐induced changes in T 1ρ (spin‐lattice relaxation rotating frame) and dispersion articular cartilage were studied at 4T. Using a spin‐lock cluster pre‐encoded fast spin echo sequence, maps of healthy bovine specimens that subjected to PG depletion computed varying frequencies. Sequential was induced by trypsinization for amounts time. Results demonstrated over 50% from resulted average increases 110–170 ms. Regression analysis the data showed strong...
Abstract Spin‐lattice relaxation in the rotating frame ( T 1ρ ) dispersion spectroscopy and imaging were used to study normal enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant “dispersion” (∼60 ∼130 ms) 100 Hz 9 kHz frequency range. Proteoglycan‐degraded have 33% greater values than collagen‐degraded or samples. ‐weighted images reveal structure not found conventional 1 ‐or 2 images. Our results suggest that measurements are selectively sensitive...
Abstract One of the initiating steps osteoarthritis is loss proteoglycan (PG) molecules from cartilage matrix. method for assessing integrity, therefore, to measure PG content or fixed charge density (FCD) cartilage. This report shows feasibility calculating FCD by 23 Na MRI and introduces protocols human studies, in vivo. was used sodium concentration inside bovine patellar The then converted (mM) considering ideal Donnan equilibrium. These measurements were compared obtained through...
In Brief Study Design. T1ρ relaxation was quantified and correlated with intervertebral disc degeneration proteoglycan content in cadaveric human lumbar spine tissue. Objective. To show the use of T1ρ-weighted magnetic resonance imaging (MRI) for assessment disc. Summary Background Data. Loss nucleus pulposus occurs during early degeneration. Conventional MRI techniques cannot detect these changes extracellular matrix is sensitive to articular cartilage may, therefore, be Methods. Intact...
Abstract Preliminary results from in vivo sodium MRI of human patellar articular cartilage are presented. Sodium images generated an vitro bovine patella clearly distinguish the region proteoglycan depletion healthy cartilage. This provides first evidence that imaging may be used to detect changes due osteoarthritis vivo. The process optimizing time and signal‐to‐noise ratio, as well potential implications detection osteoar‐thritic change, discussed.