A5006191370- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Electrolyte and hormonal disorders
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Genomics and Rare Diseases
- Blood Pressure and Hypertension Studies
- Adrenal Hormones and Disorders
- Ophthalmology and Eye Disorders
- Lipoproteins and Cardiovascular Health
- Medical research and treatments
- Hormonal Regulation and Hypertension
- Neurosurgical Procedures and Complications
- Epilepsy research and treatment
- Cardiac Arrhythmias and Treatments
- Body Image and Dysmorphia Studies
Universidad Autónoma de Madrid
1993-2024
Hospital Universitario Puerta de Hierro Majadahonda
2003-2023
Hospital Universitario La Paz
2020
Hospital Universitario Infanta Leonor
2011
Hospital General Universitario de Alicante Doctor Balmis
2005-2007
Comunidad de Madrid
2004
UCLA Medical Center
2002
Hospital Universitario Virgen del Rocío
1993-2002
University of Pennsylvania
2002
Hospital Clínico San Carlos
2002
Hemorrhagic transformation (HT) is a major complication of intra-arterial (IA) thrombolytic therapy. Identifying significant predictors hemorrhage after thrombolysis would be useful in guiding patient selection for IA treatment.Data were collected retrospectively on consecutive patients with acute focal cerebral ischemia within the anterior or posterior circulation who treated combined intravenous (IV)-IA pure over an 8-year period at UCLA Medical Center.Eighty-nine treated. Median baseline...
Background and Purpose: The coronavirus disease 2019 (COVID-19) outbreak has added challenges to providing quality acute stroke care due the reallocation of resources COVID-19. Case series suggest that patients with COVID-19 have more severe strokes; however, no large compared outcomes contemporary non–COVID-19 patients. Purpose was analyze impact pandemic in evaluate according diagnosis Methods: Retrospective multicenter cohort study including consecutive admitted 7 centers from February 25...
The COVID-19 pandemic has resulted in complete saturation of healthcare capacities, making it necessary to reorganise systems. In this context, we must guarantee the provision acute stroke care and optimise code protocols reduce risk SARS-CoV-2 infection rationalise use hospital resources. Madrid Stroke multidisciplinary group presents a series recommendations achieve these goals. We conducted non-systematic literature search using keywords "stroke" "COVID-19" or "coronavirus" "SARS-CoV-2."...
Background Hydroxymethylglutaryl coenzyme A (HMGCoA) reductase inhibitors have beneficial effects beyond their cholesterol-lowering properties. The antioxidant mechanism of HMGCoA is not completely understood. Objectives To elucidate the effect simvastatin. Methods We studied influence simvastatin treatment on development hypertension, modification systems, and reactivity aortic rings in Wistar–Kyoto (WKY) spontaneously hypertensive (SHR) rats. Results Simvastatin had no blood pressure (BP)....
Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel scale, the Madrid-Direct Referral Endovascular Center (M-DIRECT), identify EVT candidates for direct transfer EVT-capable centers (EVT-Cs). The scale evaluated clinical examination, systolic blood pressure, and age. Since March 2017, patients closer stroke unit without capabilities an M-DIRECT positive score have been transferred...
The overload of the healthcare system and organisational changes made in response to COVID-19 pandemic may be having an impact on acute stroke care Region Madrid.
Background and Purpose Reperfusion therapy is the standard of care for ischaemic stroke; however, there a need to identify new therapeutic targets able ameliorate cerebral damage. Neutrophil β 1 adrenoceptors (β1AR) have been linked neutrophil migration during exacerbated inflammation. Given central role neutrophils in damage stroke, we hypothesize that β1AR blockade will improve stroke outcomes. Experimental Approach Rats were subjected middle artery occlusion–reperfusion evaluate effect on...
The overload of the healthcare system and organisational changes made in response to COVID-19 pandemic may be having an impact on acute stroke care Region Madrid. We conducted a survey with sections addressing hospital characteristics, infrastructure resources, code clinical pathways, diagnostic testing, rehabilitation, outpatient care. performed descriptive analysis results according level complexity (availability units mechanical thrombectomy). was completed by 22 26 hospitals Madrid...
For patients with acute ischaemic stroke due to large-vessel occlusion, it has recently been shown that mechanical thrombectomy (MT) stent retrievers is better than medical treatment alone. However, few hospitals can provide MT 24 h/day 365 days/year, and remains unclear whether selected should be directly transferred the nearest MT-providing hospital prevent delays. Clinical scales such as Rapid Arterial Occlusion Evaluation (RACE) have developed predict occlusion at a pre-hospital level,...
The experience gained during the first COVID-19 wave could have mitigated negative impact on stroke care in following waves. Our aims were to analyze characteristics and outcomes of patients with admitted second evaluate differences provision compared wave.This retrospective multicenter cohort study included consecutive any seven hospitals units (SUs) endovascular treatment facilities Madrid Health Region. or without a diagnosis organizational changes between (25 February 25 April 2020) (21...
<i>Background: </i> A decreased content of n–3 fatty acids in erythrocyte membrane type 1 diabetic patients, which is inversely related to plasma levels HbA<sub>1c</sub>, has been reported previously. Our aim this study was observe the changes after a low-dose acid (330 mg/day docosahexaenoic and 630 eicosapentanoic acid) dietary intervention lipid composition cell metabolic control (measured according HbA<sub>1c</sub> levels). Since both parameters may...
Neuropathic pain (NP) is defined as that begins with or caused by a primary injury dysfunction in the nervous system.Our aim was to evaluate how often patients visit Neurology outpatients NP main reason for referral.A descriptive, cross sectional study carried out on use of health care services; attended first time Screening were included consecutively. The variables studied following: number visits and total per visiting session, rate day, topography probable causation NP, referred...
Only a minority of patients with acute stroke are eligible for fibrinolysis, and the main reason this is that time runs out goes beyond therapeutic window. The chief delay occurs prior to arrival at hospital, but there also nosocomial delay, which has received far less attention.The purpose our study was describe data on delays occurring before after hospital in sample stroke, analyse possible associated factors, including overload health care services Emergency department, an aspect not...
Intracranial stenoses (IS) are known to be a manifestation of atherosclerosis and cause cerebral ischemia, although very few clinical reports have appeared describing such patients in our milieu.The aim this study was describe the vascular risk factors, presentation, radiological characteristics, aetiological role played strokes vessels affected series Spanish suffering from stroke IS.We conducted retrospective descriptive admitted Cerebrovascular Pathology Unit with IS between 1990 2001....
Transient global amnesia (TGA) is a clinical syndrome determined by an episode of less than 24 hours consisting temporo-spatial disorientation with retrograde and anterograde followed complete recovery.To determine whether the presence or absence vascular risk factors (VRF) in patients TGA associated different data and/or examination findings.A retrospective study was made two groups 13 12 TGA, who presented without VRF, respectively. The following variables were determined: age, previous...
Involvement of the central nervous system in patients with essential mixed cryoglobulinaemia is rare, and there are few cases described medical literature. Moreover, mechanism by which lesions produced still not clear.We describe case a 35 year old woman who presented dysarthria, weakness paraesthesia her left limbs facial paralysis sudden onset. Vascular studies showed presence IgG-IgM polyclonal positive cryoglobulins polymerase chain reaction (PCR) hepatitis C virus to be present....