A5003688409- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- earthquake and tectonic studies
- Cardiovascular Health and Disease Prevention
- Geological and Geochemical Analysis
- Geological and Tectonic Studies in Latin America
- Cardiovascular and Diving-Related Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Geological and Geophysical Studies Worldwide
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- S100 Proteins and Annexins
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Transcranial Magnetic Stimulation Studies
- Neurological Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Blood Pressure and Hypertension Studies
Complejo Hospitalario Torrecárdenas
2018-2025
University of Almería
2021-2025
Complejo Hospitalario Universitario de Toledo
2025
Universidade Federal de Pernambuco
2025
Hospital La Paz Institute for Health Research
2011-2024
Universidad Autónoma de Madrid
2010-2024
Hospital Universitario La Paz
2011-2022
Research Institute Hospital 12 de Octubre
2009-2022
Latin American and Caribbean Society of Medical Oncology
2022
Universidad Nacional de Asunción
2022
We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls.Fifteen AD (mean age 72 ± 6 years, Mini-Mental State Examination score [MMSE] 20 6) and 19 controls 68 MMSE 29 1) underwent structural MRI. Participants were injected 5 mCi FDG during pseudocontinuous ASL scan, which was followed by PET scanning. Statistical parametric mapping...
Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but benefits and risks survivors intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs risk ischaemic stroke without substantially increasing recurrent haemorrhage. PRESTIGE-AF is a multicentre, open-label, randomised, phase 3 trial conducted at 75 hospitals six European countries. Eligible were aged 18 years or older spontaneous haemorrhage, fibrillation, an...
We recently identified the thalamic dopaminergic system in human and macaque monkey brains, and, based on earlier reports paucity of dopamine rat thalamus, hypothesized that this was particularly developed primates. Here we test hypothesis using immunohistochemistry against transporter (DAT) adult brains. The extent density DAT-immunoreactive (-ir) axons were remarkably greater dorsal where mediodorsal association nucleus ventral motor nuclei held densest immunolabeling. In contrast, sparse...
Impaired cognitive flexibility is associated with the characteristic symptomatology of ADHD and OCD. However, mechanisms underlying learning under uncertainty in adults OCD or remain unclear. This study aimed to identify contingency-based a sample OCD, using probabilistic reversal task, functional near-infrared spectroscopy, computational modelling. 148 Spanish-speaking (43 53 52 healthy controls) completed task. Previously, we obtained resting-state connectivity (rsFC) record between...
The complexity of endovascular revascularization treatment (ERT) in acute ischemic stroke and the small number patients eligible for justify development center networks with interhospital patient transfers. However, this approach might result futile transfers (ie, transfer who ultimately do not undergo ERT). Our aim was to analyze frequency these reasons discarding ERT identify possible associated factors.We analyzed an observational prospective registry from a collaboration network...
Several clinical scales have been developed for predicting stroke recurrence. These scores could be extremely useful to guide triage decisions. Our goal was compare the very early predictive accuracy of most relevant [age, blood pressure, features and duration symptoms (ABCD) score, ABCD diabetes (ABCD2) brain infarction on imaging ABCD2 prior TIA within 1 week index event (ABCD3) California Risk Score, Essen Stroke Score Prognosis Instrument II] in consecutive transient ischemic attack...
Background and purpose The benefits of mechanical thrombectomy (MT) in basilar artery occlusions (BAO) have not been explored recent clinical trials. We compared outcomes procedural complications MT BAO with anterior circulation occlusions. Methods Data from the Madrid Stroke Network multicenter prospective registry were analyzed, including baseline characteristics, procedure times, complications, symptomatic intracranial hemorrhage (SICH), modified Rankin Scale (mRS), mortality at 3 months....
Background and Purpose Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated intravenous tissue plasminogen activator (tPA), the effect of timing tPA-induced recanalization on functional outcomes remains debatable.Methods We conducted a multicenter, prospective observational cohort study to determine whether (within 1-hour from tPA-bolus) complete or partial assessed during 2-hour real-time transcranial Doppler monitoring...
The origin of Patagonia and its relations with the South American crustal blocks to north have been a matter debate for decades. We report results from multidisciplinary study centered on Paleozoic granitoids exposed in northeastern corner North Patagonian Massif. Microstructural magnetofabric studies reveal two suites granitoids. Late Carboniferous (?) (Yaminue Complex, Tardugno Granodiorite, Cabeza de Vaca leucogranite) were emplaced subsequently deformed major NNE-SSW compressive stress...
<i>Background:</i> Methods to assess impaired consciousness in acute stroke typically include the Glasgow Coma Scale (GCS), but verbal component has limitations aphasic or intubated patients. The FOUR (Full Outline of UnResponsiveness) score, a new coma scale, evaluates 4 components: eye and motor responses, brainstem reflexes respiration. We aimed study interobserver variability score <i>Methods:</i> prospectively enrolled consecutive patients with admitted from...
Background Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of these early-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions poorly documented causality like patent foramen ovale and coagulopathies. Key hypotheses/aims (1) Investigate transient triggers clinical/sub-clinical chronic risk factors IS the young; (2) use cardiac imaging methods exceeding state-of-the-art reveal novel sources for embolism; (3) search...
<h3>Background</h3> Many guidelines recommend urgent intervention for patients with two or more transient ischaemic attacks (TIAs) within 7 days (multiple TIAs) to reduce the early risk of stroke. <h3>Objective</h3> To determine whether all multiple TIAs have same high <h3>Methods</h3> Between April 2008 and December 2009, we included 1255 consecutive a TIA from 30 Spanish stroke centres (PROMAPA study). We prospectively recorded clinical characteristics. also determined short-term (at 90...