A5075877585- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Folate and B Vitamins Research
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- Esophageal and GI Pathology
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Antiplatelet Therapy and Cardiovascular Diseases
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- MRI in cancer diagnosis
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Kruppel-like factors research
- Radiomics and Machine Learning in Medical Imaging
- Blood Pressure and Hypertension Studies
Lund University
2016-2025
Skåne University Hospital
2016-2025
Scania (Sweden)
2021-2024
University of Maryland, Baltimore
2010-2024
Yale University
2024
University of California, Los Angeles
2020-2024
King's College London
2024
Population Health Research Institute
2024
University of Calgary
2024
St. Thomas Hospital
2024
Background and Purpose— The causes of death patients with cerebral venous thrombosis (CVT) have not been systematically addressed in previous studies. We aimed to analyze the predictors during acute phase CVT International Study on Cerebral Vein Dural Sinus Thrombosis (ISCVT) identify preventable or treatable causes. Methods— ISCVT is a multinational, prospective, observational study including 624 occurring between May 1998 2001, which 27 (4.3%) died phase, 21 (3.4%) within 30 days from...
Abstract. Objectives. Hyperhomocysteinaemia is an independent risk factor for cardiovascular disease. We explored possible determinants of plasma homocysteine and cysteine concentrations amongst middle‐aged elderly subjects. Design Of 501 35–95‐year‐old randomly selected residents Lund Malmö, Sweden, 244 (49%; 131 men, 113 women) were investigated. Results. Total higher in men than women (mean ± SD: 13.9 4.1 12.3 μmol L −1 ; P < 0.001), increased markedly with age (Spearman's p = 0.488;...
Background and Purpose— We examined longitudinal changes of quality life (QOL) covering physical mental factors in an unselected group stroke patients their informal caregivers. Our hypothesis was that caregivers would have better QOL than at both follow-ups, changes, if any, be related to the patients’ status. Methods— 304 consecutive 234 from population-based Lund Stroke Register assessed 4 months after onset with Short Form 36 (SF-36) questionnaire. SF-36 repeated for groups 16 together...
Atrial fibrillation (AF) is a common cause of devastating but potentially preventable stroke. Estimates the prevalence AF among patients with stroke vary considerably because difficulties in detection intermittent, silent AF. Better recognition this patient group may help to identify and offer protection individuals at risk. Our aim was determine nationwide ischemic stroke, as well their use oral anticoagulation.Cross-sectional study unselected cross-linked Swedish health registers. All 94...
Abstract Objective Prior studies investigating the association between APOE alleles ε2/ε4 and risk of intracerebral hemorrhage (ICH) have been inconsistent limited to small sample sizes, did not account for confounding by population stratification or determine which genetic model was best applied. Methods We performed a large‐scale study 2189 ICH cases 4041 controls from 7 cohorts, were analyzed using additive models ε2 ε4. Results subsequently meta‐analyzed random effects model. A...
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, death. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist with clinical decisions about management ccSVD, specifically white matter hyperintensities lacunes, prevent adverse outcomes. The were developed according ESO standard operating...
BackgroundPatients with acute intracerebral hemorrhage who are receiving factor Xa inhibitors have a risk of hematoma expansion. The effect andexanet alfa, an agent that reverses the effects inhibitors, on volume expansion has not been well studied.MethodsWe randomly assigned, in 1:1 ratio, patients had taken within 15 hours before having to receive or usual care. primary end point was hemostatic efficacy, defined by 35% less at 12 after baseline, increase score National Institutes Health...
A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist clinical decisions about management prevent adverse outcomes. The was developed according ESO standard operating procedures Grading Recommendations, Assessment,...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 157:139-146 (1997) - doi:10.3354/meps157139 Effects of UV-B radiation and simulated herbivory on phlorotannins in brown alga Ascophyllum nodosum Henrik Pavia*, Gunnar Cervin, Annelie Lindgren, Per Åberg Department Botany, University Göteborg, Carl Skottsbergs Gata 22, S-413 19 Sweden *E-mail:...
Background and Purpose— Shoulder pain is a well-known complication after stroke, but data on prevalence, predictors, outcome in unselected stroke populations are limited. Methods— During 1-year period, 416 first-ever patients were included the population-based Lund Stroke Register. After 4 months, 327 followed up 1 year later, surviving 305 again. General status (National Institutes of Health Scale score) was registered at onset. intensity (visual analog scale, score 0 to 30=no–mild 40...
Moderate hyperhomocysteinaemia is a frequent finding in atherothrombotic cerebrovascular disease. This study confirms and extends this observation. Hyperhomocysteinaemia was present 57 of 142 survivors with stroke (40%) four 66 controls (6%). Plasma homocysteine concentrations were increased not only carotid artery disease or lucunar but also haemorrhagic embolic strokes. Homocysteine values unrelated to the presence hypertension, smoking, hypercholesterolaemia, blood glucose, glycosylated...
Background and Purpose Stroke patients frequently manifest moderate hyperhomocysteinemia. In most published studies, plasma homocysteine was measured at least 1 month after stroke (or the interval not reported). To determine whether concentrations change in acute phase, we compared acute-phase values with both convalescent-phase control values. Methods Plasma were phase (mean, 2 days onset) 162 first-ever aged 50 years or more (median, 75 years) again a median of 583 (range, 460 to 645 days)...
Object. Predictors of early (30-day) and long-term (1-year) mortality rates after primary intracerebral hemorrhage (ICH) were studied in a large population southern Sweden. Methods. All cases ICH, verified using computerized tomography (CT) scanning or autopsy study, prospectively registered at the 12 hospitals covering defined 1.14 million during calendar year 1996. Mortality was analyzed relation to CT findings (hematoma location volume ventricular extension) clinical parameters (patient...
Abstract. Objectives . Moderate hyperhomocysteinaemia is an independent risk factor for cardiovascular disease which may be causal. We investigated whether the concentration of plasma homocysteine changes between acute phase myocardial infarction and follow‐up, treatment with oral folic acid was effective in lowering levels patients infarction. Design subjects Plasma total 24–36 h (baseline) after onset were compared obtained at 6 weeks' follow‐up controls. In same patients, we studied...
We report trends of stroke incidence and survival up to year 2001/2002 in Lund-Orup, Sweden, projections future Sweden.Lund Stroke Register, a prospective population-based study, included all first-ever patients, between March 1, 2001 February 28, 2002, the Lund-Orup health care district. Institution-based studies for 1983 1985 1993 1995 were used comparison. calculated age-standardized Cox proportional hazards analysis (stroke subtype, sex, age group, study period analysis). Minimum...
Background and Purpose— Data on the prevalence indicators of weight loss in population-based groups stroke survivors are scarce. We aimed to find predictors >3 kg as a possible marker malnutrition after stroke. Methods— registered at baseline, 4 months, 1 year later 305 from cohort first-ever patients. Characteristics patients were baseline follow-ups, including glycosylated hemoglobin follow-up II, eating difficulties both screening for depression II. used univariate multivariate...
Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. However, long-term studies PSCI are scarce may be influenced by assessment methods selection bias. We aimed to (i) assess the prevalence of PSCI; (ii) compare two common instruments; (iii) function stroke survivors with non-stroke persons.Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) were administered 10-year from a population-based cohort first-ever included in Lund Stroke...
Background and Purpose— Previous studies suggest that genetic variation plays a substantial role in occurrence evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because lack large pedigree-based studies. However, novel analytic tool based on genome-wide data allows estimation from unrelated subjects. We sought apply this method provide estimates risk,...
Background Embolic strokes of undetermined source comprise up to 20% ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. New Approach riVaroxaban Inhibition Factor Xa in a Global trial versus ASA prevenT Embolism Stroke Undetermined Source international will compare the efficacy and safety rivaroxaban, an oral factor inhibitor, aspirin prevention patients recent embolic source. Main hypothesis In source, rivaroxaban 15 mg once daily...
Abstract Acute ischemic stroke affects men and women differently. In particular, are often reported to experience higher acute severity than men. We derived a low-dimensional representation of anatomical lesions designed Bayesian hierarchical modeling framework tailored estimate possible sex differences in lesion patterns linked (National Institute Health Stroke Scale). This was developed 555 patients (38% female). Findings were validated an independent cohort (n = 503, 41% Here, we show...