Steven J. T. Mocking
A5037930891- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Trigeminal Neuralgia and Treatments
- Cerebrovascular and genetic disorders
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Brain Tumor Detection and Classification
- Functional Brain Connectivity Studies
- Medical Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Migraine and Headache Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience of respiration and sleep
Athinoula A. Martinos Center for Biomedical Imaging
2014-2022
Massachusetts General Hospital
2011-2022
Harvard University
2019-2022
Centre de Recherche Jean Pierre Aubert
2022
Centre Hospitalier Universitaire de Lille
2022
Université de Lille
2022
Inserm
2022
Massachusetts Institute of Technology
2020
Broad Institute
2020
Harvard University Press
2019
Acute infarct volume, often proposed as a biomarker for evaluating novel interventions acute ischemic stroke, correlates only moderately with traditional clinical end points, such the modified Rankin Scale. We hypothesized that topography of stroke lesions on diffusion-weighted magnetic resonance imaging may provide further information regard to presenting severity and long-term functional outcomes. Data from prospective repository were limited subjects completed within 48 hours last known...
Abstract Acute ischemic stroke affects men and women differently. In particular, are often reported to experience higher acute severity than men. We derived a low-dimensional representation of anatomical lesions designed Bayesian hierarchical modeling framework tailored estimate possible sex differences in lesion patterns linked (National Institute Health Stroke Scale). This was developed 555 patients (38% female). Findings were validated an independent cohort (n = 503, 41% Here, we show...
White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis diseases, such as acute ischemic stroke (AIS). However, current approaches its quantification on clinical MRI often rely time intensive manual delineation the disease T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses genetic discovery. In this work, we present fully automated pipeline for WMH in large-scale studies...
Background and Purpose— We evaluated deep learning algorithms’ segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted magnetic resonance imaging (MRI) data sets explored the potential role this tool for phenotyping stroke. Methods— Ischemic stroke from MRI-GENIE (MRI-Genetics Interface Exploration) repository consisting 12 international genetic research centers were retrospectively analyzed using an automated algorithm ensemble 3-dimensional...
To examine whether high white matter hyperintensity (WMH) burden is associated with greater stroke severity and worse functional outcomes in lesion pattern-specific ways.MR neuroimaging NIH Stroke Scale data at index the modified Rankin (mRS) score 3-6 months after were obtained from MRI-Genetics Interface Exploration study of patients acute ischemic (AIS). Individual WMH volume was automatically derived fluid-attenuated inversion recovery images. lesions segmented diffusion-weighted imaging...
Accurate automated infarct segmentation is needed for acute ischemic stroke studies relying on volumes as an imaging phenotype or biomarker that require large numbers of subjects. This study investigated whether ensemble convolutional neural networks trained multiparametric DWI maps outperforms single solo parametric maps.Convolutional were combinations DWI, ADC, and low b-value-weighted images from 116 The performances the (measured by Dice score, sensitivity, precision) compared with one...
To examine etiologic stroke subtypes and vascular risk factor profiles their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic (AIS).
Abstract Objective Posterior circulation ischemic stroke (PCiS) constitutes 20–30% of cases. Detailed information about differences between PCiS and anterior (ACiS) remains scarce. Such might guide clinical decision making prevention strategies. We studied risk factors subtypes in vs. ACiS lesion location on magnetic resonance imaging (MRI) PCiS. Methods Out 3,301 MRIs from 12 sites the National Institute Neurological Disorders Stroke (NINDS) Genetics Network (SiGN), we included 2,381 cases...
<h3>Objective:</h3> To describe the design and rationale for genetic analysis of acute chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with ischemic stroke (AIS) within scope MRI–GENetics Interface Exploration (MRI-GENIE) study. <h3>Methods:</h3> MRI-GENIE capitalizes existing infrastructure Stroke Genetics Network (SiGN). In total, 12 international SiGN sites contributed MRIs 3,301 AIS. Detailed phenotyping web-based Causative Classification (CCS) system...
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate association between excessive white matter hyperintensity (WMH) burden unaccounted for by traditional stroke risk profile individual patients and their long-term functional outcomes after a stroke. Methods: We included 890 who survived an acute ischemic from MRI-Genetics Interface Exploration (MRI-GENIE) study, whom data on vascular factors (VRFs),...
Stroke represents a considerable burden of disease for both men and women. However, growing body literature suggests clinically relevant sex differences in the underlying causes, presentations outcomes acute ischaemic stroke. In recent study, we reported divergences lesion topographies: specific to women, stroke severity was linked lesions left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. relied on 822...
Background Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic lesion appearance is therefore an essential tool linking genetic traits stroke. Building on baseline MRI examinations from the centralized structured radiological assessments patients Stroke Genetics Network (SiGN), results MRI-Genetics Interface Exploration (MRI-GENIE) study are described this work. Methods The MRI-GENIE included with...
To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) anterior (ACiS), we generated polygenic risk scores (PRSs) compared these PCiS ACiS, separately vs. non-stroke control subjects.Acute cases were classified as or ACiS based on lesion location diffusion-weighted MRI. Exclusion criteria lesions in both vascular territories uncertain territory; supratentorial with ipsilateral fetal cerebral artery; atrial...
Abstract This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich‐club) brain regions on functional outcome post‐stroke, determine their spatial specificity and explore effects biological sex relevance. We analyzed MRI data recorded at index ~3‐months modified Rankin Scale (mRS) from patients with acute ischemic enrolled multisite MRI‐GENIE study. Spatially normalized structural were parcellated into 108 atlas‐defined bilateral (sub)cortical...
Abstract White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis diseases, such as acute ischemic stroke (AIS). However, current approaches its quantification on clinical MRI often rely time intensive manual delineation the disease T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses genetic discovery. In this work, we present fully automated pipeline for WMH in large-scale...
Background: We investigated whether MRI-based algorithms combining acute DWI & PWI can be used to identify patients likely experience lesion expansion. Methods: analyzed MRI from 181 unilateral stroke who underwent ≤ 12h last seen well and had follow-up imaging (F/u) ≥4 days with lesions ≥ 1 cm 3 . Apparent diffusion coefficient, T2, DWI, CBF, CBV, MTT Tmax (time of peak deconvolved residue function) maps were co-registered, normalized as covariates in a model that produced infarction...
Background purpose A substantial number of patients with acute ischemic stroke (AIS) experience multiple lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and methods Analyses relied upon imaging clinical data from the international MRI-GENIE study. Imaging comprised both Fluid-attenuated inversion recovery (FLAIR) for white matter hyperintensity (WMH) burden estimation diffusion-weighted (DWI) sequences assessment lesions. The initial...
Abstract Objective To examine whether high white matter hyperintensity (WMH) burden is associated with greater stroke severity and worse functional outcomes in lesion pattern-specific ways. Methods MR neuroimaging National Institutes of Health Stroke Scale data at index stroke, as well modified Rankin (mRS) 3-6 months post-stroke were obtained from MRI-GENIE study acute ischemic (AIS) patients. Individual WMH volume was automatically derived FLAIR-images. lesions segmented DWI-images,...
Abstract Background A substantial number of patients with acute ischemic stroke (AIS) experience multiple lesions (MAL). However, the spatial distribution and clinical implications such MAL are incompletely understood. Methods Analyses relied upon imaging data AIS from international MRI-GENIE study. Initially, we systematically evaluated occurrences within (i) one and, (ii) several vascular supply territories. Associations between presence important characteristics, as DWI lesion volume,...
Abstract Acute ischemic stroke affects men and women differently in many ways. In particular, are oftentimes reported to experience a higher acute severity than men. Here, we derived low-dimensional representation of anatomical lesions designed sex-aware Bayesian hierarchical modelling framework for large-scale, well phenotyped cohort. This was tailored carefully estimate possible sex differences lesion patterns explaining (NIHSS) 1,058 patients (39% female). Anatomical regions known...
Background: In acute ischemic stroke (AIS) patients, multi-parametric MRI-based predictive algorithms have shown promise in identifying tissue at risk of infarction, but do not consider the intrinsic variations normal or pathological tissue. We hypothesized that extending to take into consideration type will improve predictions outcome. Methods: retrospectively analyzed AIS patients who received neither revascularization nor experimental interventional treatment, underwent MRI within 12 h...
Background: There is increasing interest in using oxygen challenges during MRI to image metabolic dysfunction acute ischemic stroke. Methods: Subjects enrolled a prospective study of patients imaged within 48 h stroke onset underwent arterial spin labeling (ASL) for 10-12 min, while receiving transient normobaric (NBO) challenge, according this protocol: (1) Room air (RA) 2-5 min; (2) NBO at L/min via nonrebreather mask 4 (3) RA 2-4 min. ASL data were motion corrected and used calculate CBF....
Background: Increases in oxygen extraction fraction (OEF) are postulated to be a marker of tissue at risk infarction acute ischemic stroke patients. R2’, parameter that can measured rapidly using an asymmetric spin echo MRI sequence (ASE), considered OEF-weighted metric, being combination both OEF and venous cerebral blood volume. We investigated the feasibility utility stroke. Methods: Adult patients were prospectively enrolled 3T study imaged within 48 hours onset. Only subset whose...