A5101992184- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Blood Coagulation and Thrombosis Mechanisms
- Cerebrovascular and genetic disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Risk Factors
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Cardiac Imaging and Diagnostics
- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
Royal Holloway University of London
2016-2025
Imperial College London
2011-2024
Imperial College Healthcare NHS Trust
2017-2024
National Institute of Technology Hamirpur
2024
Dr. D.Y. Patil Vidyapeeth, Pune
2024
New York University
2024
Ashford and St Peter's Hospitals NHS Foundation Trust
2017-2023
All India Institute of Medical Sciences Rishikesh
2022-2023
Maulana Azad Institute of Dental Sciences
2023
Father Muller Homoeopathic Medical College
2023
The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial disorder that results in reduced contractile function, is largely unknown. Some cases familial cardiomyopathy are caused by mutations cardiac cytoskeletal proteins; this finding implicates defects contractile-force transmission as one mechanism underlying disorder. To elucidate important cause heart failure, we investigated other genetic causes cardiomyopathy.
A critical decision-step in the emergency treatment of ischemic stroke is whether or not to administer thrombolysis — a that can result good recovery, deterioration due symptomatic intracranial haemorrhage (SICH). Certain imaging features based upon early computerized tomography (CT), combination with clinical variables, have been found predict SICH, albeit modest accuracy. In this proof-of-concept study, we determine machine learning CT images which patients receiving tPA will develop SICH...
Objectives To describe incidence and prevalence of cardiovascular disease (CVD), its risk factors, medication prescribed to treat CVD predictors within a nationally representative dataset. Design Cross-sectional study adults with without CVD. Setting The Royal College General Practitioners (RCGP) Research Surveillance Centre (RSC) is an English primary care sentinel network. RCGP RSC over 50 years old one the oldest in Europe. Practices receive feedback about data quality. This database...
Valid and reliable ischemic stroke subtype determination is crucial for well-powered multicenter studies. The Causative Classification of Stroke System (CCS, available at http://ccs.mgh.harvard.edu) a computerized, evidence-based algorithm that provides both causative phenotypic subtypes in rule-based manner. We determined whether CCS demonstrates high interrater reliability order to be useful international studies.Twenty members the International Genetics Consortium from 13 centers 8...
Background and Purpose— We evaluated deep learning algorithms’ segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted magnetic resonance imaging (MRI) data sets explored the potential role this tool for phenotyping stroke. Methods— Ischemic stroke from MRI-GENIE (MRI-Genetics Interface Exploration) repository consisting 12 international genetic research centers were retrospectively analyzed using an automated algorithm ensemble 3-dimensional...
Background and Purpose: The causes of recurrent ischemic stroke despite anticoagulation for atrial fibrillation are uncertain but might include small vessel occlusion. We investigated whether magnetic resonance imaging markers cerebral disease (SVD) associated with risk during follow-up in patients anticoagulated after recent or transient attack. Methods: analyzed data from a prospective multicenter inception cohort study attack (CROMIS-2 [Clinical Relevance Microbleeds Stroke Study]). rated...
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanisms condition identify drug targets, we established a patient-specific induced pluripotent stem cell (iPSC) model demonstrated for first time failure patient iPSC-derived mural cells (iPSC-MCs) engaging stabilizing endothelial capillary structures. The...
Background and Purpose- Information on what effect disability before stroke can have outcome is lacking. We assessed prestroke in relation to poststroke hospital outcome. Methods- Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme. A total 1656 men (mean age ±SD =73.1±13.2 years) 1653 women (79.3±13.0 were admitted hyperacute units with acute 4 major UK between 2014 2016. Prestroke disability, by modified Rankin Scale (mRS), was tested against adverse...
Most National Health Service (NHS) hospital bed occupants are older patients because of their frequent admissions and prolonged length stay (LOS). We evaluated demographic clinical factors as predictors LOS in a single NHS Trust derived an equation to estimate LOS.Stepwise logistic linear regressions were used predict (upper-quintile > 17 days) respectively, from acute pre-existing conditions.Of 374 (men:women = 127:247) admitted (20% orthogeriatric, 69% general medical 11% surgical wards),...