A5042145465- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Vascular Procedures and Complications
- Breast Cancer Treatment Studies
- Aortic aneurysm repair treatments
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Nanoplatforms for cancer theranostics
- Infective Endocarditis Diagnosis and Management
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Dermatological and Skeletal Disorders
- Neurological Disease Mechanisms and Treatments
University Medical Center Utrecht
2015-2024
Utrecht University
2015-2024
Heidelberg University
2009-2024
University Hospital Heidelberg
2009-2024
University Medical Center
2007-2020
Maasstad Ziekenhuis
2020
Erasmus MC
2011-2016
Mali-Folkecenter
2013-2016
St. Antonius Ziekenhuis
2016
Maastricht University
2015
There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers.
The use of multidetector computed tomography (CT) in lung-cancer screening trials involving subjects with an increased risk lung cancer has highlighted the problem for clinician deciding on best course action when noncalcified pulmonary nodules are detected by CT.A total 7557 participants underwent CT years 1, 2, and 4 a randomized trial screening. We used software to evaluate nodule according its volume or volume-doubling time. Growth was defined as increase at least 25% between two scans....
Background: Little is known about the efficacy and safety of renal artery stenting in patients with atherosclerotic stenosis (ARAS) impaired function. Objective: To determine stent placement ARAS Design: Randomized clinical trial. Randomization was centralized computer generated, allocation assigned by e-mail. Patients, providers, persons who assessed outcomes were not blinded to treatment assignment. Setting: 10 European medical centers. Participants: 140 creatinine clearance less than 80...
Extremely dense breast tissue is a risk factor for cancer and limits the detection of with mammography. Data are needed on use supplemental magnetic resonance imaging (MRI) to improve early reduce interval cancers in such patients.In this multicenter, randomized, controlled trial Netherlands, we assigned 40,373 women between ages 50 75 years extremely normal results screening mammography group that was invited undergo MRI or received only. The groups were 1:4 ratio, 8061 MRI-invitation...
A method to obtain the optimal selection criteria, taking into account available resources and capacity impact on power, is presented for Dutch-Belgian randomised lung cancer screening trial (NELSON). NELSON investigates whether 16-detector multi-slice computed tomography will decrease mortality compared no screening. questionnaire was sent 335,441 (mainly) men, aged 50-75. Smoking exposure (years smoked, cigarettes/day, years quit) determined, expected estimated different scenarios 106,931...
Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy uncertain. We report data from the randomised International Carotid Study comparison these treatments.Patients with symptomatic stenosis were randomly assigned 1:1 open stenting or at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call fax. Major outcomes assessed independent endpoint committee unaware assignment. The primary fatal...
Background and Purpose —Diffusion-weighted MRI (DWI) is highly sensitive in detecting early cerebral ischemic changes acute stroke patients. In this study we compared the sensitivity of DWI with that conventional techniques. Furthermore, investigated prognostic value volume lesions on scans apparent diffusion coefficient (ADC). Methods —We performed DWI, fluid-attenuated inversion recovery, spin-echo T2-weighted MRI, proton density–weighted 42 patients 15 control subjects. The was measured...
Purpose: To provide proof of principle safety, breast tumor-specific uptake, and positive tumor margin assessment the systemically administered near-infrared fluorescent tracer bevacizumab-IRDye800CW targeting VEGF-A in patients with cancer.Experimental Design: Twenty primary invasive cancer eligible for surgery received 4.5 mg as intravenous bolus injection. Safety aspects were assessed well uptake delineation during ex vivo surgical specimens using an optical imaging system. Ex multiplexed...
The NELSON (Nederlands Leuvens Longkanker Screenings Onderzoek) trial is, with 15,822 participants, the largest European lung cancer computer tomography screening trial. A volumetry-based strategy, stringent criteria for a positive screening, and an increasing length of interval are particular features trial.To determine effect referral on characteristics screen-detected cancers, to compare this across rounds, between sexes, other trials.All participants in first three rounds were included....
Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on potential harms and benefits their risk is a prerequisite screening. In NELSON trial, screenings are considered positive (part) solid nodules with volume >500 mm3 or nonsolid volume-doubling time <400 days. For this study, performance strategy in three rounds was evaluated calculations were made follow-up period 5.5 years. 458 (6%)...
Introduction We related composition of cerebral thrombi to stroke subtype and attenuation on non-contrast CT (NCCT) gain more insight in etiopathogenesis validate thrombus as a new imaging biomarker for acute stroke. Methods histopathologically investigated 22 retrieved after mechanical thrombectomy patients. First, were classified fresh, lytic or organized. Second, percentages red blood cells (RBCs), platelets fibrin number red, white (respectively RBCs outnumbering other components with...
Background In the first (prevalent) supplemental MRI screening round of Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial, a considerable number breast cancers were found at cost an increased false-positive rate (FPR). incident rounds, lower cancer detection (CDR) is expected due to smaller pool prevalent cancers, reduced FPR, availability prior examinations. Purpose To investigate performance indicators second (incidence round) DENSE trial. Materials Methods The trial...
PURPOSE: To establish normal reference values for the presence of anatomic variants circle Willis and average diameters its component vessels by using three-dimensional time-of-flight magnetic resonance (MR) angiography to determine whether age- or sex-related differences exist in circle's anatomy. MATERIALS AND METHODS: One hundred fifty volunteers were grouped according age: those aged 20-25 years (n = 50) 60-88 100). All subjects underwent MR arterial at 1.5 T. The anterior posterior...
This study was done to assess how local changes in vessel size, together with plaque load, determine luminal narrowing atherosclerotic arteries. Fifty-one human femoral arteries were analyzed: 32 postmortem and 19 vivo by 30-MHz intravascular ultrasound.Histological ultrasound cross sections examined every 0.5 cm over an arterial segment 10 15 long. In each section we measured the lumen area circumscribed internal elastic lamina (the IEL area). segment, that contained least amount of...