A5075192372- Barrier Structure and Function Studies
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Multisensory perception and integration
- Neurobiology of Language and Bilingualism
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Advanced Neuroimaging Techniques and Applications
- Ophthalmology and Eye Disorders
- Peripheral Neuropathies and Disorders
- Neurological Disease Mechanisms and Treatments
- Hearing Loss and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Caveolin-1 and cellular processes
- Complement system in diseases
- Neuroscience and Neuropharmacology Research
- Neurogenetic and Muscular Disorders Research
- Neurosurgical Procedures and Complications
- Action Observation and Synchronization
- Wnt/β-catenin signaling in development and cancer
- Noise Effects and Management
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
University College London
2014-2024
UK Dementia Research Institute
2022-2024
National Hospital for Neurology and Neurosurgery
2014-2024
Wexham Park Hospital
2020-2023
Frimley Health NHS Foundation Trust
2020-2023
University College London Hospitals NHS Foundation Trust
2020-2021
Health Foundation
2020
Guy's and St Thomas' NHS Foundation Trust
2014-2015
Guy's Hospital
2008
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Cerebral blood flow is reduced early in the onset of Alzheimer's disease (AD). Because most vascular resistance within brain capillaries, this could reflect dysfunction contractile pericytes on capillary walls. We used live and rapidly fixed biopsied human tissue to establish relevance, rodent experiments define mechanism. found that humans with cognitive decline, amyloid β (Aβ) constricts capillaries at pericyte locations. This was caused by Aβ generating reactive oxygen species, which...
Abstract Reports of Guillain-Barré syndrome (GBS) have emerged during the Coronavirus disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection GBS. The epidemiology GBS cases reported UK National Immunoglobulin Database was studied from 2016 compared Data were stratified by hospital trust region, with numbers per month. population data for collated public health bodies. In parallel, but separately,...
Successful communication in daily life depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task is vulnerable to neurodegenerative pathologies. However, despite recent intense interest link between hearing impairment and dementia, comprehension these diseases has been little studied. Here we addressed this issue cohort 19 patients typical Alzheimer's disease 30...
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We describe two women presenting with severe postpartum headache associated hypertension but no other signs or investigation results to suggest pre-eclampsia. In one case, the was atypical subarachnoid haemorrhage. The variable nature of and degree raised clinical suspicion reversible cerebral vasoconstriction syndrome, confirmed on MR angiography. Both patients took nimodipine until had resolved radiologically.
Abstract Background Reports of Guillain-Barré Syndrome (GBS) have emerged during the Coronavirus Disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection GBS. Methods The epidemiology GBS cases reported via UK National Immunoglobulin Database were studied from 2016-2019 compared For study, members British Peripheral Nerve Society all clinical features, investigation findings outcomes (definite or...
Vascular compromise occurs early in Alzheimer’s disease (AD) and other dementias 1–3 . Amyloid β (Aβ) reduces cerebral blood flow 4–6 and, as most of the vasculature resistance is capillaries 7 , Aβ might mainly act on contractile pericytes capillary walls 8–10 Employing human tissue to establish disease-relevance, rodent experiments define mechanism, we now show that constricts brain at pericyte locations subjects with cognitive decline. Applying soluble 1-42 oligomers live cortical...
<title>Abstract</title> <bold>Background</bold>: Prosody refers to nonverbal speech features including pitch, intonation, stress, duration and intensity. These are critical for successful communication, conveying emotions distinguishing sentence structures. Previous research suggests that emotional prosody perception is impaired in neurodegenerative diseases like Alzheimer’s disease (AD) primary progressive aphasia (PPA). However, no previous has investigated how affected these patient...
To define the mechanism reducing cerebral blood flow in Alzheimer's disease (AD).
ABSTRACT Successful communication in daily life frequently depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task is vulnerable to neurodegenerative pathologies. However, despite recent intense interest link between hearing impairment and dementia, measures (such as comprehension) these diseases remain poorly defined. Here we addressed this issue cohort 19 patients...
Vaughan, R2; De Freitas, S1; Mamode, N1; Nortley, R1; Hangartner, R3; Else, J4; Shaw, O2; O'Donnell, P3 Author Information