A5083938120- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- COVID-19 Clinical Research Studies
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- Renal and Vascular Pathologies
- Birth, Development, and Health
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- Reproductive Health and Contraception
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Medical and Health Sciences Research
- Chronic Kidney Disease and Diabetes
- SARS-CoV-2 detection and testing
- Assisted Reproductive Technology and Twin Pregnancy
- Child and Adolescent Health
- Pneumonia and Respiratory Infections
- Clinical Laboratory Practices and Quality Control
- Muscle and Compartmental Disorders
- Ureteral procedures and complications
- Eosinophilic Esophagitis
Barts Health NHS Trust
2020-2025
King's College London
2015-2024
Kings Health Partners
2024
Queen Mary University of London
2024
Royal London Hospital
2020-2024
Mile End Hospital
2024
East London NHS Foundation Trust
2023
RELX Group (United States)
2023
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
Background Chronic kidney disease (CKD) is estimated to affect 3% of pregnant women in high-income countries, (Piccoli et al., 2018, #13860) which equates between 15,000–20,000 pregnancies per year England. The prevalence CKD pregnancy predicted rise the future due increasing maternal age and obesity. Although not a barrier reproduction most women, risk adverse outcomes increased with including pre-eclampsia, fetal growth restriction, preterm delivery accelerated loss renal function....
Women with chronic kidney disease have an increased risk of maternal and fetal complications in pregnancy. Pre-pregnancy counselling is recommended but the format process experience patient never been assessed. This study examines women attending pre-pregnancy evaluates their pregnancy outcomes. a cross-sectional assessment 179 clinic (2003–2011) retrospective evaluation aetiology, comorbidity, treatment adverse outcome compared 277 hospital controls. It includes analysis descriptive data...
Contemporaneous data are required for women with chronic kidney disease (CKD) Stages 3-5 to inform pre-pregnancy counselling and institute appropriate antenatal surveillance.A retrospective cohort study in CKD after 20 weeks' gestation was undertaken six UK tertiary renal centres the between 2003 2017. Factors predicting adverse outcomes impact of pregnancy accelerating need replacement therapy (RRT) were assessed.There 178 pregnancies 159 women, including 43 transplants. The live birth rate...
Individualized pre-pregnancy counseling and antenatal care for women with chronic kidney disease (CKD) require disease-specific data. Here, we investigated pregnancy outcomes long-term function in COL4A3-5 related (Alport Syndrome, (AS)) a large multicenter cohort. The ALPART-network (mAternaL fetal PregnAncy of AlpoRT syndrome), an international collaboration 17 centers, retrospectively pregnancies after the 20th week. Outcomes were stratified per inheritance pattern (X-Linked AS (XLAS)),...
<h3>ABSTRACT</h3> Severe hypertension in pregnancy is defined as a sustained systolic blood pressure of 160 mmHg or over diastolic 110 and should be assessed hospital. before 20 weeks' gestation rare usually due to chronic hypertension; assessment for target organ damage exclusion secondary are warranted. The most common cause severe pre-eclampsia, which presents after gestation. This warrants more rapid control the risk haemorrhagic stroke, intravenous antihypertensive agents may required....
ABSTRACT Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity infection. Little information is available on disease vaccine since dissemination Omicron variant. Methods In a multi-center study, during period epidemic driven by variant, all hemodialysis positive for SARS-CoV-2 were identified. Outcomes analyzed according to predictor variables including status. Risk infection was using Cox...
Diagnosis of superimposed preeclampsia in women with chronic kidney disease (CKD) is complicated by the presence hypertension and proteinuria due to renal disease. The aims this study were determine mechanistic links between renin-angiotensin system activation, endothelial pathology, complement dysfunction, tubular injury, explore role diagnostic indicators preeclampsia.Plasma urinary biomarkers derived from (active renin, angiotensinogen), glycocalyx (hyaluronan, intercellular adhesion...
ABSTRACT Objective To determine characteristics and pregnancy outcomes in women with primary adrenal insufficiency (PAI). Design Retrospective multicentre cohort study. Setting Twenty‐three maternity units the UK Ireland. Sample Seventy‐nine PAI who had 101 pregnancies. Method chart analysis. Main Outcome Measures Adrenal crisis, outcomes. Results We obtained data on pregnancies 79 PAI. Most (51, 64.1%) autoimmune disease, 8 (10.3%) prior infarction/surgery/haemorrhage, 2 (2.6%) congenital...
Abstract Objectives To evaluate PlGF, sFlt-1, and novel endothelial biomarkers hyaluronan vascular cell adhesion molecule (VCAM), for the prediction of superimposed pre-eclampsia in women with chronic kidney disease (CKD). Study design Prospective cohort study pregnant CKD UK. Main outcome measures Outcomes including were based on predetermined criteria. Test performances plasma serum sFlt-1:PlGF, VCAM concentrations evaluated as area under receiver-operating curve at established exploratory...
Everyone agrees that current advice on alcohol is inconsistent and confusing, but whereas <b>Mary Mather</b> <b>Kate Wiles</b> conclude we should move to a clear recommendation abstain, <b>Patrick O'Brien</b> thinks it wrong assume pregnant women cannot understand the evidence