A5038687403- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Renal Diseases and Glomerulopathies
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Frailty in Older Adults
- Sarcoidosis and Beryllium Toxicity Research
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemodynamic Monitoring and Therapy
- Muscle and Compartmental Disorders
- Rheumatoid Arthritis Research and Therapies
- COVID-19 and healthcare impacts
- Body Composition Measurement Techniques
- Potassium and Related Disorders
- Local Governance and Development
- Patient Satisfaction in Healthcare
- Ultrasound in Clinical Applications
- Patient Safety and Medication Errors
- Inflammasome and immune disorders
- Anesthesia and Sedative Agents
University College London
2020-2024
The Royal Free Hospital
2020-2024
Barts Health NHS Trust
2021-2022
Royal Free London NHS Foundation Trust
2021-2022
Universitas Patria Artha
2021
Broomfield Hospital
2016-2017
Mid Essex Hospital Services NHS Trust
2017
University of Cologne
2008-2011
The aim of this study was to investigate the frequency CYP2B6 polymorphisms (according ethnicity) and influence heterozygosity homozygosity on plasma concentrations efavirenz nevirapine. Following written informed consent, 225 Caucasians 146 Blacks were recruited from German Competence Network for HIV/AIDS. Plasma nevirapine assessed by HPLC, genotyping 516G>T, 983T>C 1459T>C in conducted real-time PCR-based allelic discrimination. minor allele 0.29, 0 0.08 0.34, 0.07 0.02 Blacks,...
Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in CYP2B6 gene are associated with pharmacokinetics. Since constitutive androstane receptor (CAR) pregnane X (PXR) correlate liver, a CAR polymorphism (rs2307424) smoking plasma concentrations, we investigated their association early (<3 months) discontinuation therapy. Three hundred seventy-three patients initiating therapy an efavirenz-based regimen were included...
The pandemic of coronavirus disease (COVID-19) has highly affected patients with comorbidities and frailty who cannot self-isolate, such as individuals undergoing haemodialysis. aim the study was to identify risk factors for mortality hospitalisation, which may be useful in future spikes.
BackgroundNevirapine is metabolized by CYP2B6 and polymorphisms within the gene partly explain inter-patient variability in pharmacokinetics. The aim of this study was to model complex relationship between nevirapine exposure, weight genetics (based on combined analysis 516G > T 983T C single nucleotide polymorphisms).
ABSTRACT Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity infection. Little information is available on disease vaccine since dissemination Omicron variant. Methods In a multi-center study, during period epidemic driven by variant, all hemodialysis positive for SARS-CoV-2 were identified. Outcomes analyzed according to predictor variables including status. Risk infection was using Cox...
Status asthmaticus can develop into a life-threatening disorder that requires mechanical ventilation. Severe respiratory failure during pregnancy worsen maternal and fetal outcomes. Previous case studies have demonstrated extracorporeal membrane oxygenation (ECMO) as life-saving measure for pregnant women with acute distress syndrome (ARDS) well non-pregnant patients status asthmaticus.A 25-year-old woman, who was 5 weeks pregnant, admitted severe hypercapnic failure. Despite rescue...
Less active haemodialysis patients have an increased risk of mortality. We wished to determine which factors were associated with energy expenditure (AEE). used the validated recent physical activity questionnaire AEE and estimated dietary protein intake creatinine generation rates. measured extracellular total body water ratio (ECW/TBW) appendicular lean muscle bioimpedance arm strength by hand grip (HGS). Patients graded using Charlson co-morbidity Clinical Frailty Score (CFS). was...
Until now, there have been many cases of tax evasion that occurred in Indonesia. Fraud is an act deviation or omission intentionally carried out to deceive, other parties suffering losses fraud perpetrators obtaining financial benefits, either directly indirectly. The design this research based on literature review. Tax policy the majority countries was oriented towards mitigating health impacts and preventing economic pressure. Recently we also seen motives various world want achieve as...
Background: Both frailty and cachexia increase mortality in haemodialysis (HD) patients. The clinical score (CFS) is a seven-point scale less complex than other assessments. We wished to determine the characteristics of frail HD patients using CFS. Methods: Single centre cross-sectional study completing physical activity questionnaires with bioimpedance measurements body composition hand grip strength (HGS). Results: studied 172 CFS classified 54 (31.4%) as frail, who were older (70.4±12.2...
Glucocorticoids have been a cornerstone of treatment for inflammatory and autoimmune kidney diseases almost 70 years, yet it is fair to say, we still do not know how 'best' use them. Significant adverse events are associated with their continued use, which contribute premature patient mortality. Steroid avoidance or minimization possible has tested in various glomerular diseases, as result novel agents innovative regimens using established therapeutics. It now time seriously address our...
The Department of Health's 'High Impact Intervention (HII) - Peripheral intravenous cannula care bundle' lists six actions to be performed at the time peripheral cannulation. Audit compliance these requires documentation. We assessed documentation on anaesthetic charts 50 surgical patients. Purpose-made stickers were then placed all charts. Re-assessment a further patients' demonstrated significant improvement in bundle post intervention (Fisher's exact test P < 0.0001). This is an example...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Journal of the American Society Nephrology 33(11S):p 984, November 2022. | DOI: 10.1681/ASN.20223311S1984b
Abstract Background and Aims Initial WHO guidance advised cautious fluid administration for patients with COVID-19 due to concern about the development of acute respiratory distress syndrome (ARDS). However, as pandemic unfolded it became apparent that who were admitted hospital had high rates AKI this initiated a change in local clinical guidelines during early April 2020. We aimed ascertain impact judicious intravenous use on mortality, length hospitalisation AKI. Method An observational...
Cove-smith, Andrea; Thyagarajan, Sujanita; Mccafferty, Kieran; Forbes, Suzanne H.; Hendra, Heidy; O'Sullivan, Natasha P. Author Information