A5020847019- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Selenium in Biological Systems
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Electrolyte and hormonal disorders
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Caveolin-1 and cellular processes
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Healthcare Systems and Challenges
- Global Maternal and Child Health
- Metabolomics and Mass Spectrometry Studies
- Maternal and Perinatal Health Interventions
- Trace Elements in Health
- Renal function and acid-base balance
- Cardiac, Anesthesia and Surgical Outcomes
- Child Nutrition and Water Access
- Aldose Reductase and Taurine
- Chronic Kidney Disease and Diabetes
- Gestational Trophoblastic Disease Studies
King's College London
2011-2025
University of Leicester
2025
Dartmouth Hospital
2024
Dartmouth College
2024
Monash University
2024
University of British Columbia
2023
University of Nottingham
2008-2020
Nottingham City Hospital
2010-2019
University of Bern
2014-2018
University Hospital of Bern
2015-2016
Preeclampsia is pregnancy-specific, affecting 2% to 7% of women, and a leading cause perinatal maternal morbidity mortality. may also predispose the fetus increased risks adult cardiovascular disease. Selenium, acting through selenoprotein glutathione peroxidases, has critical roles in regulating antioxidant status. Recent reports implicate poor selenium status as nutritional factor predisposing mother preeclampsia but placenta have not been studied tandem. Measurement concentrations,...
ABSTRACT Background Existing reviews of pre‐eclampsia determinants have focused on clinical and genetic risk factors. Objective To evaluate social for prevention. Search Strategy Systematic searches were conducted from relevant electronic databases inception each database to 30th December 2024. Selection Criteria Reviews large cohort studies (≥ 1000 participants), published between 2013 2024, reporting quantitative associations determinant exposures outcomes. Data Collection Analysis Titles...
ABSTRACT Background Risk factors for the placental disorders of pregnancy (pre‐eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving interplay between clinical wider social environmental determinants health. Biomarkers modulate maternal responses to biological processes that underlie development disorders. Objectives To develop a standardised methodology assess importance of, inter‐relationships between, candidate risk various Search Strategy...
Pregnancy during adolescence increases the risk of adverse pregnancy outcome, especially small-for-gestational-age (SGA) birth, which has been linked to micronutrient deficiencies. Smoking shown be related lower concentrations. Different ethnicities have not examined. We used a subset from prospective observational study, About Teenage Eating study consisting 126 pregnant adolescents (14-18-year-olds) between 28 and 32 weeks gestation. Micronutrient status was assessed by inductively coupled...
To compare pre-eclampsia risk factors identified by clinical practice guidelines (CPGs) with from hierarchical evidence review, to guide prevention.
Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the cardiovascular metabolic systems. As nutrition important to support optimal development placenta for developing fetus, diets may play role in preventing pre-eclampsia. The purpose this scoping review map nutritional deficiencies imbalances associated with pre-eclampsia incidence discuss evidence consistency linkages current understandings etiology
Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and leading cause perinatal maternal morbidity mortality. Deficiencies specific micronutrient antioxidant activities associated with copper, selenium, zinc, manganese have previously been linked to preeclampsia at the time disease. Our aims were investigate whether plasma concentrations related enzyme are altered before onset examine dependence on genetic variations in these enzymes. Predisease samples (15±1 weeks׳...
Up to 11% of pregnancies extend post-term with adverse obstetric events linked over 42 weeks. Oxidative stress and senescence (cells stop growing dividing by irreversibly arresting their cell cycle gradually ageing) can result in diminished function. There are no detailed studies placental markers across a range gestational ages, although increased levels have been pre-eclampsia before full term. This study aimed determine oxidative ages women uncomplicated those diagnosis pre-eclampsia....
Women of reproductive age are a group particular concern with regards to vaccine uptake, related their unique considerations menstruation, fertility, and pregnancy. To obtain uptake data specific this group, we obtained surveillance from the Office for National Statistics, linked COVID-19 vaccination status Immunisation Management Service, England, 8 Dec 2020 15 Feb 2021; 13,128,525 such women at population-level, were clustered by (18-29, 30-39, 40-49 years), self-defined ethnicity (19 UK...
Abstract Preeclampsia (PE) poses a considerable risk to the long‐term cardiovascular health of both mothers and their offspring due hypoxic environment in placenta leading reduced fetal oxygen supply. Cholesterol is vital for development by influencing placental function. Recent findings suggest an association between hypoxia, disturbed cholesterol homeostasis, PE. This study investigates influence hypoxia on homeostasis. Using primary human trophoblast cells placentae from women with PE,...
COVID-19 vaccination rates are lower in women of reproductive age (WRA), including pregnant/postpartum women, despite their poorer COVID-19-related outcomes. We evaluated the experiences 3568 U.K. WRA, 1983 (55.6%) experiencing a pandemic pregnancy, recruited through ZOE COVID Symptom Study app. Two staggered online questionnaires (Oct–Dec 2021: 3453 responders; Aug–Sept 2022: 2129 responders) assessed status, vaccination, and attitudes for/against vaccination. Descriptive analyses included...
<h3>Abstract</h3> <b>Objective:</b> To evaluate the potential effect of computer support on general practitioners9 prescribing, and to compare effectiveness three different levels. <b>Design:</b> Crossover experiment with balanced block design. <b>Subjects:</b> Random sample 50 practitioners (42 agreed participate) from 165 in a geographically defined area Oxfordshire. <b>Interventions:</b> Doctors prescribed for 36 simulated cases constructed real consultations. Levels were control...
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease cholesterol efflux capacity linked CVD. We hypothesized preeclampsia there would be disruption of maternal/fetal plasma cholesterol, as well differences the concentrations both placental sterol 27-hydroxylase (CYP27A1) and apoA1 binding protein (AIBP). Total, HDL-, ABCA1-mediated effluxes were performed with maternal fetal from women normotensive controls (both n = 17). apoE...
Maternal vaccination during pregnancy, in general and against COVID-19 infection, offers protection to both mother baby, but uptake remains suboptimal. This study aimed explore the perceptions regarding particularly for marginalised populations those living with social or medical complexity. A total of 96 semi-structured in-depth interviews were conducted 40 women, 15 partners, 21 HCPs, 20 policy makers, across all four nations United Kingdom (UK), discussing their lived experience...
Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. Voltage-dependant potassium channels encoded by KCNQ1-5 genes have been detected several types of blood vessels where they promote vascular relaxation. channel function can be modulated KCNE1-5–encoded accessory proteins. The aim this study was to determine whether KCNQ KCNE are differentially expressed placentas from women preeclampsia compared normotensive controls examine any...