A5088222987- Malaria Research and Control
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Drug Transport and Resistance Mechanisms
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Biochemical and Molecular Research
- Hemoglobinopathies and Related Disorders
- Bacterial Genetics and Biotechnology
- Viral Infections and Outbreaks Research
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Genomics and Phylogenetic Studies
- Renal function and acid-base balance
- Pharmacological Effects and Toxicity Studies
- COVID-19 epidemiological studies
Acharya N. G. Ranga Agricultural University
2025
Kasturba Medical College, Manipal
2008-2025
St George's, University of London
2015-2024
Universitätsklinikum Tübingen
2015-2024
Centre de Recherche Médicales de Lambaréné
2013-2024
University of Tübingen
2002-2024
St George’s University Hospitals NHS Foundation Trust
2017-2024
Vijayanagara Institute of Medical Sciences
2017-2024
University of Malaya
2024
German Center for Infection Research
2015-2024
Abstract Updates This is the fourteenth version (thirteenth update) of living guideline, replacing earlier versions (available as data supplements). New recommendations will be published updates to this guideline. Clinical question What role drugs in treatment patients with covid-19? Context The evidence base for therapeutics covid-19 evolving numerous randomised controlled trials (RCTs) recently completed and underway. Emerging SARS-CoV-2 variants subvariants are changing therapeutics. new?...
Zinc fingers are small protein domains in which zinc plays a structural role contributing to the stability of domain. structurally diverse and present among proteins that perform broad range functions various cellular processes, such as replication repair, transcription translation, metabolism signaling, cell proliferation apoptosis. typically function interaction modules bind wide variety compounds, nucleic acids, molecules. Here we comprehensive classification finger spatial structures. We...
Aquaporin-4 (AQP4) is the major water channel in brain, expressed predominantly astroglial cell membranes. Initial studies AQP4-deficient mice showed reduced cellular brain edema following intoxication and ischemic stroke. We hypothesized that AQP4 deletion would have opposite effect (increased swelling) vasogenic (noncellular) because of impaired removal excess through glial limitans ependymal barriers. In support this hypothesis, we found higher intracranial pressure (ICP, 52+/-6 vs....
We studied the occurrence, clinical manifestations, and mechanism of hypoglycemia in patients with falciparum malaria eastern Thailand. Hypoglycemia, which was often severe recurrent, occurred 17 patients, including 12 a series 151 cerebral malaria. Thirty episodes were investigated. Plasma concentrations insulin C peptide inappropriately high, lactate alanine significantly higher than who normoglycemic (P less 0.05). Sixteen had received quinine; plasma quinine correlated at time = 0.007)....
The replication-competent recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicity testing before its use in West Africa.We performed three open-label, dose-escalation phase 1 trials one randomized, double-blind, controlled trial to assess the safety, side-effect profile, of rVSV-ZEBOV at various doses 158 healthy adults Europe Africa. All participants were injected with ranging from...
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)–based combination therapies for malaria, including mefloquine (MFQ)–artesunate and lumefantrine (LUM)–artemether. Clinical studies have identified an association between increased risk MFQ, MFQ-artesunate, LUM-artemether treatment failures pfmdr1 gene amplification. To directly address the contribution that copy number makes drug resistance, we genetically disrupted 1 2...
Abstract Clinical question What is the role of drugs in preventing covid-19? Why does this matter? There widespread interest whether drug interventions can be used for prevention covid-19, but there uncertainty about which drugs, if any, are effective. Recommendations The second version living guideline reiterates previous strong recommendation against use hydroxychloroquine and includes a new conditional tixagevimab-cilgavimab individuals who do not have covid-19. How was created This from...
Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining therapeutic response to artemether-lumefantrine (AL).
ABSTRACT On the western border of Thailand, Plasmodium falciparum has become resistant to almost all antimalarial agents. The molecular basis resistance in these parasite populations not been well characterized. This study assessed genetic polymorphisms pfmdr1 gene 54 parasites collected from Thailand determine relationship copy number and codon mutations with sensitivities mefloquine, chloroquine, halofantrine, quinine, artesunate vitro. A point mutation at 86 (resulting a change Asn Tyr)...
Journal Article Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological prognostic significance Get access S. Krishna, Krishna ∗ 1Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand ∗Present address (for correspondence): Department Cellular Molecular Sciences, Division Communicable Diseases, St George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK. Search for other works by this author on: Oxford...
Aquaporin 1 is a water channel protein. There was little aquaporin immunoreactivity in normal brain parenchyma. In astrocytomas, expressed microvessel endothelia and neoplastic astrocytes. metastatic carcinomas, present reactive may participate the formation of tumour oedema.