A5028001297- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- Blood Coagulation and Thrombosis Mechanisms
- Migraine and Headache Studies
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical studies and practices
- Pharmacology and Obesity Treatment
- Gastrointestinal Tumor Research and Treatment
- Aortic Disease and Treatment Approaches
- Family Support in Illness
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Multiple Sclerosis Research Studies
- Sleep and related disorders
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Pharmacovigilance and Adverse Drug Reactions
National Hospital for Neurology and Neurosurgery
2014-2024
University College London
2014-2024
Tallaght University Hospital
2015-2024
Trinity College Dublin
2016-2024
The Royal Free Hospital
2020-2024
Royal Free London NHS Foundation Trust
2020
University College London Hospitals NHS Foundation Trust
2020
University College Hospital
2020
Boston Children's Hospital
2015
Kyung Hee University
2007
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Summary To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. There transient delirium (with and without hypoxia) after COVID-19 infection as well other neurological manifestations. We report on a female patient who, post-COVID-19 infection, developed an initial followed by florid consisting persecutory delusion, complex visual auditory hallucinations Capgras phenomenon in the absence hypoxia...
Abstract Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where how occurs, we collected serum CSF from patients with COVID-19 characterized neurological syndromes involving PNS CNS (n = 34). We measured biomarkers of neuronal neuroinflammation, compared these non-neurological control groups, which included 94) without 24) COVID-19. detected increased concentrations neurofilament light, a dynamic damage, in those...
BackgroundData are limited on the ability of dipyridamole to additionally inhibit platelet function/reactivity in ischaemic cerebrovascular disease (CVD) patients aspirin.AimsTo assess inhibition and activation with CVD.MethodsThis prospective, observational study assessed TIA/ischaemic stroke before (baseline; N = 60), at 14 ±7 days (14d, 39) ≥ 90 (90d, 31) after adding aspirin. Platelet high shear stress (PFA-100® C-ADP) low (VerifyNow® P2Y12 Multiplate® ADP assays), status (% expression...
The relationship between plaque morphology, cerebral micro-embolic signals (MES) and platelet biomarkers in carotid stenosis patients warrants investigation. We combined data from two prospective, observational studies to assess morphology with MES recently symptomatic (≤4 weeks of transient ischaemic attack (TIA)/ischaemic stroke) versus asymptomatic stenosis. Plaque on ultrasound was graded Grey-Scale Median (GSM) Gray–Weale (GW) scoring. Bilateral transcranial Doppler classified as...
Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare %RP using whole blood flow cytometry ≤ 4 weeks TIA/stroke onset (baseline, N = 210), and 14 ±7 days (14d, 182) ≥ 90 (90d, 145) after starting or changing antiplatelet therapy with healthy controls (N 34). There no differences median between overall CVD patient population at...
Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative 'recently symptomatic patients' also have a higher than 'asymptomatic patients'. Differences platelet activation status may contribute to this disparity risk. This prospective, observational study assessed biomarkers and their relationship with MES asymptomatic versus moderate (≥50-69%) or severe (≥70-99%) Full blood count parameters were measured whole-blood flow cytometry was...
Abstract Background The relationship between von Willebrand factor antigen (VWF:Ag), VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio, ADAMTS13 activity, and microembolic signal (MES) status in carotid stenosis is unknown. Methods This prospective, multicenter study simultaneously assessed plasma VWF:Ag levels, VWFpp levels their with MES asymptomatic versus symptomatic moderate-to-severe (≥50–99%) patients. One-hour transcranial Doppler ultrasound of the middle cerebral arteries classified...
Data are limited on the impact of commencing antiplatelet therapy von Willebrand Factor Antigen (VWF:Ag) or propeptide (VWFpp) levels and ADAMTS13 activity, their relationship with platelet reactivity following TIA/ischaemic stroke. In this pilot, observational study, VWF:Ag VWFpp activity were quantified in 48 patients ≤4 weeks stroke (baseline), 14 days (14d) 90 (90d) after aspirin, clopidogrel aspirin+dipyridamole. Platelet was assessed at moderately-high shear stress (PFA-100®...
<title>Abstract</title> Background Simultaneously-collected data regarding platelet reactivity and activation status in ischaemic cerebrovascular disease (CVD) patients commencing commonly-prescribed antiplatelet agents are limited. Methods This prospective pilot observational study assessed TIA/ischaemic stroke before (<bold>baseline</bold>; N = 73), 14 +/-7 days (<bold>14d</bold>; 59) ≥ 90 (<bold>90d</bold>; 38) after aspirin or clopidogrel monotherapy. Platelet at low shear-stress whole...
A 76-year-old man developed recurrent encephalopathy, visual disturbance, myoclonus, generalised seizures and atonic drop attacks on a background of gastrectomy for adenocarcinoma stable chronic lymphocytic leukaemia. He presented to three different hospitals was admitted twice, with normal investigations. His symptoms transiently improved during each admission (and starting levetiracetam) but recurred time hospital discharge. Subsequent careful inspection his medication box identified that...
Greater Occipital Nerve (GON) infiltrations with local anaesthetic and steroid have been utilized in primary headache disorders for decades. Despite this we are not aware of significant long-term data tolerability effectiveness beyond 26 months.
Introduction: Cerebral microembolic signals (MES) predict increased stroke risk in carotid stenosis however micro-emboli negative symptomatic patients also demonstrate compared to asymptomatic patients. Enhanced platelet activation may contribute this disparity. Methods: We performed a prospective, observational analytical study assessing counts, status, and the relationship between MES versus moderate (≥50-69%) or severe (≥70-99%) stenosis. Full blood count measurements were performed,...