A5022275028- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Geriatric Care and Nursing Homes
- Transcranial Magnetic Stimulation Studies
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Mitochondrial Function and Pathology
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Workplace Health and Well-being
- Child Nutrition and Water Access
- Healthcare professionals’ stress and burnout
- Tryptophan and brain disorders
- Mental Health Research Topics
- Alzheimer's disease research and treatments
- Coenzyme Q10 studies and effects
- Autism Spectrum Disorder Research
- Memory and Neural Mechanisms
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Poverty, Education, and Child Welfare
- Metabolism and Genetic Disorders
University College London
2015-2025
Mental Health Research UK
2018-2025
National Institute on Aging
2024
St George's, University of London
2024
National Institutes of Health
2024
National Hospital for Neurology and Neurosurgery
2020
Faculty (United Kingdom)
2018
MRC Mitochondrial Biology Unit
2009-2016
Mother and Infant Research Activities
2015
Summary To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. There transient delirium (with and without hypoxia) after COVID-19 infection as well other neurological manifestations. We report on a female patient who, post-COVID-19 infection, developed an initial followed by florid consisting persecutory delusion, complex visual auditory hallucinations Capgras phenomenon in the absence hypoxia...
Motivational symptoms such as apathy and anhedonia are common in Parkinson's disease (PD), respond poorly to treatment, hypothesised share underlying neural mechanisms. Striatal dopaminergic dysfunction is considered central motivational PD but the association has never been examined longitudinally. We investigated whether progression of was associated with emergent PD.Longitudinal cohort study 412 newly diagnosed patients followed over 5 years part Progression Markers Initiative...
It has been suggested that the diagnostic landscape of Alzheimer disease (AD) is undergoing a profound transformation, marked by shift toward biomarker-based approach, as proposed Revised Criteria for Diagnosis and Staging Alzheimer's Disease. These criteria advocate diagnosing AD solely on biomarkers, without requiring clinical symptoms. This article explores drivers behind this transition, primarily influenced Food Drug Administration's approval amyloid-lowering treatments. We evaluate...
Mutations in the nuclear gene POLG (encoding catalytic subunit of DNA polymerase gamma) are an important cause mitochondrial disease. The most common mutation, A467T, appears to exhibit considerable phenotypic heterogeneity. mechanism by which this single genetic defect results such clinical diversity remains unclear. In study we evaluate clinical, neuropathological and features four unrelated patients with homozygous A467T mutations. One patient presented severe lethal Alpers-Huttenlocher...
Abstract Background staff burnout and turnover lead to care home residents receiving poorer quality care. Burnout is thought cause turnover, but this has never been investigated. We know little about which staffs are burnt out. Aims explore burnout’s relationship with prevalence predictors of burnout. Method we calculated the between Maslach Inventory scores future (12-month number leaving/number employed). explored staff, resident burnout, measured as emotional exhaustion (EE),...
Background The mitochondrial DNA mutation m.1555A>G predisposes to permanent idiosyncratic aminoglycoside-induced deafness that is independent of dose. Research suggests in some families, may cause non-syndromic deafness, without aminoglycoside exposure, as well reduced hearing thresholds with age (age-related loss). Objectives To determine whether adults have impaired hearing, a factor would inform the cost-benefit argument for genetic testing prior administration. Design Population-based...
Background: Recent research has highlighted the need for additional studies on nutrition input required to stabilize growth. Objective: Our objective was examine association between dietary diversity and conditional growth in children aged 0–89 mo. Methods: We analyzed cohort data from 529 mothers living a remote food-insecure region mountains of Nepal. Children were 0–59 mo at baseline followed up after 9 29 Conditional calculated as deviation expected height-for-age difference (HAD)...
Abstract Willingness to exert effort for a given goal is dependent on the magnitude of potential rewards and costs an action. Such effort-based decision making essential component motivation, in which dopaminergic system plays key role. Depression Parkinson’s disease (PD) common, disabling has poor outcomes. Motivational symptoms such as apathy anhedonia, are prominent PD depression related loss. We hypothesised that dopamine-dependent disruption decision-making contributes PD. In present...
Cognitive impairment has a major impact on health, quality of life and survival its increasing burden presents critical global health challenge. Empirical population-based studies cognitive function association with demographic, socioeconomic, behavioural factors among older adults in low-resource setting are rare. This study describes the associations rural Bangladesh. We conducted cross-sectional random sample men women aged 60 years above 96 villages was measured using Bangla Adaptation...
Aims and method Neuropsychiatry training in the UK currently lacks a formal scheme or qualification, its demand availability have not been systematically explored. We conducted largest UK-wide survey of psychiatry trainees to examine their experiences neuropsychiatry training. Results In total, 185 from all regions completed survey. Although 43.6% expressed interest career, only 10% felt they would gain sufficient experience by end Insufficient access clinical rotations was most common...
Abstract Willingness to exert effort for a given goal is dependent on the magnitude of potential rewards and costs an action. Such effort-based decision making essential component motivation, in which dopaminergic system plays key role. Depression Parkinson’s disease (PD) common, disabling has poor outcomes. Motivational symptoms such as apathy anhedonia, are prominent PD depression related loss. We hypothesised that dopamine-dependent disruption decision-making contributes PD. In present...
Depression in Parkinson disease (PD) is common, disabling and responds poorly to standard antidepressants. Motivational symptoms of depression are particularly prevalent PD emerge with loss dopaminergic innervation the striatum. Optimizing treatment for can improve depressive symptoms. However, differential effect antiparkinsonian medication on symptom dimensions not known. Using data from a large (
Agitation in Alzheimer's disease (AD) has been hypothesized to be an expression of anxiety, but whether anxiety early the course dementia could a risk factor for developing later agitation is unknown.
Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking those other antidepressants.
Functional visual symptoms are relatively common seen by ophthalmologists. However, there no consensus guidelines on ophthalmological management of this condition, and is a paucity knowledge about the collective challenges experienced in treating patients with functional symptoms. In order to establish an perspective we undertook first national survey experience, amongst ophthalmologists.An online was disseminated ophthalmologists UK via all Royal College Ophthalmology college tutors.One...