A5053787562- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Air Quality and Health Impacts
- Autoimmune Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Angiogenesis and VEGF in Cancer
- Biomarkers in Disease Mechanisms
- Energy and Environment Impacts
- S100 Proteins and Annexins
- Occupational Therapy Practice and Research
- Myasthenia Gravis and Thymoma
- Brain Metastases and Treatment
- Blood properties and coagulation
- Kruppel-like factors research
- Multiple Sclerosis Research Studies
Mass General Brigham
2025
Boston University
2014-2023
Massachusetts General Hospital
2012-2022
Framingham Heart Study
2014-2022
Boston Medical Center
2022
Harvard University
2012-2020
Carmel Medical Center
2017
University Medical Center Utrecht
2016-2017
Naresuan University
2016-2017
Université Paris Cité
2017
<h3>Importance</h3> Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important diagnosis to reach in clinical practice because many patients with the disease respond immunosuppressive therapy. Reliable noninvasive diagnostic criteria for CAA-ri would allow some avoid risk of brain biopsy. <h3>Objective</h3> To test sensitivity and specificity neuroimaging-based CAA-ri. <h3>Design, Setting, Participants</h3> We modified previously proposed clinicoradiological retrospectively...
To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) hypertensive arteriopathy (HA).Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease markers, including microbleeds (CMBs), cortical superficial siderosis (cSS), white matter hyperintensities...
Cerebral microbleeds (CMBs) are associated with increased risk of stroke and poor cognition. Vascular factors medications used for prevention may increase the CMB. We examined prevalence CMB association these CMB, postulating that cerebral amyloid angiopathy would be lobar markers hypertensive vasculopathy deep CMB.We include 1965 Framingham Original Offspring participants (age, 66.5±11.0 years; 54% women) evaluated age- sex-specific related various vascular genetic (apolipoprotein E [APOE])...
To identify different white matter hyperintensity (WMH) patterns between 2 hemorrhage-prone cerebral small vessel diseases (SVD): amyloid angiopathy (CAA) and hypertensive arteriopathy (HA).
<h3>Importance</h3> Cerebral amyloid angiopathy (CAA) is characteristically associated with magnetic resonance imaging (MRI) biomarkers of small vessel brain injury, including strictly lobar cerebral microbleeds, cortical superficial siderosis, centrum semiovale perivascular spaces, and white matter hyperintensities. Although these neuroimaging markers reflect distinct pathophysiologic aspects in CAA, no studies to date have combined structural features gauge total disease burden CAA....
It is uncertain whether neurogenesis occurs in humans after stroke. We studied the morphologic changes that occurred subventricular zone (SVZ) patients who died following an acute ischemic stroke.We examined coronal brain slices from a first-ever cerebral nonlacunar infarction middle artery territory. evaluated ipsilateral and contralateral SVZ by light electron microscopy. Using immunochemistry with Ki-67 PCNA, we detected cell proliferation. used Tuj-1 for immature neurons PSA-NCAM...
Abstract Objective: In addition to its role in hemorrhagic stroke, advanced cerebral amyloid angiopathy (CAA) is also associated with ischemic lesions and vascular cognitive impairment. We used functional magnetic resonance imaging (MRI) techniques identify CAA‐associated dysfunction. Methods: Functional MRI was performed on 25 nondemented subjects probable CAA (mean ± standard deviation age, 70.2 7.8 years) 12 healthy elderly controls (age, 75.3 6.2 years). Parameters measured were...
Cerebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for cognitive impairment. The mechanisms linking to impairment are not well understood. We hypothesized that in patients with cerebral angiopathy, multiple small spatially distributed lesions affect cognition through disruption brain connectivity. therefore compared the structural network healthy control subjects examined relationship between markers angiopathy-related injury, efficiency,...
<h3>Objective:</h3> To investigate whether the topography of dilated perivascular spaces (DPVS) corresponds with markers particular small-vessel diseases such as cerebral amyloid angiopathy and hypertensive vasculopathy. <h3>Methods:</h3> Patients were recruited from an ongoing single-center prospective longitudinal cohort study patients evaluated in a memory clinic. All underwent structural, high-resolution MRI, had clinical assessment performed within 1 year scan. DPVS rated basal ganglia...
Objective We hypothesized that vascular amyloid contributes to chronic brain ischemia, therefore burden measured by Pittsburgh compound B retention on positron emission tomography (PiB PET) would correlate with the extent of magnetic resonance imaging (MRI) white matter hyperintensities (WMH; or leukoaraiosis) in patients high deposition (cerebral angiopathy [CAA]) but not parenchymal (Alzheimer disease [AD]; mild cognitive impairment [MCI]) healthy elderly (HE) subjects. Methods Forty‐two...
Abstract Introduction The Boston criteria are the basis for a noninvasive diagnosis of cerebral amyloid angiopathy (CAA) in setting lobar intracerebral hemorrhage (ICH). We assessed accuracy these individuals with microbleeds (MBs) without ICH. Methods identified aged >55 years having brain magnetic resonance imaging (MRI) and pathological assessment CAA single academic hospital community‐based population (Framingham Heart Study [FHS]). determined positive predictive value (PPV) both...
BackgroundLoss of cortical grey matter is a diagnostic marker many neurodegenerative diseases, and key mediator cognitive impairment. We postulated that cerebral amyloid angiopathy (CAA), characterised by vascular deposits, associated with tissue loss independent parenchymal Alzheimer's disease pathology. tested this hypothesis in patients hereditary haemorrhage amyloidosis–Dutch type (HCHWA-D), monogenetic minimal or no concomitant pathology, as well sporadic CAA healthy controls.MethodsIn...
To gain insight into different cerebral amyloid angiopathy (CAA) phenotypes and mechanisms, we investigated cortical superficial siderosis (CSS), a new imaging marker of the disease, its relation with APOE genotype in patients pathologically proven CAA, who presented without intracerebral hemorrhage (ICH).MRI scans 105 CAA pathologic confirmation MRI were analyzed for CSS (focal, ≤3 sulci; disseminates, ≥4 sulci) other markers. We compared pathologic, imaging, data between subjects vs ICH,...
In order to explore the mechanisms of cortical superficial siderosis (cSS) multifocality and its clinical implications for recurrent intracerebral hemorrhage (ICH) risk in patients with cerebral amyloid angiopathy (CAA), we used a new rating method that developed specifically evaluate cSS extent at spatially separated foci.Consecutive CAA-related ICH according Boston criteria from single-center prospective cohort were analyzed. The score assesses (total range 0-4) showed excellent interrater...
<h3>Background</h3> There is growing evidence regarding the importance of contextual factors for patient/staff outcomes and likelihood successfully implementing safety improvement interventions such as checklists; however, certain literature gaps still remain—for example, lack research examining interactive effects constructs on outcomes. This study has addressed some these gaps, together with adding to our understanding how context influences safety. <h3>Purpose</h3> The impact staff...
Perivascular spaces are an emerging marker of small vessel disease. in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular and angiopathy severity has not established. We examined this association using post-mortem magnetic resonance imaging five cases evidence pathology. Juxtacortical dilation was evaluated on T2 images related to overlying cortical areas 34 tissue sections stained for Amyloid...
<h3>Objectives:</h3> To determine whether small diffusion-weighted imaging (DWI) lesions occur beyond the acute posthemorrhage time window in patients with intracerebral hemorrhage (ICH) and to characterize their spatial distribution lobar deep cerebral hemorrhages. <h3>Methods:</h3> In this cross-sectional study, we retrospectively analyzed 458 MRI scans obtained (≤7 days after ICH) or nonacute (>14 phases from 392 subjects strictly (n = 276) 116) ICH (48.7% women; mean age 72.8 ± 11.7...
We sought to explore the mechanisms leading cerebral amyloid angiopathy (CAA)-related cortical superficial siderosis (cSS) by examining its neuroimaging and genetic association with microbleeds (CMBs).MRI scans of 84 subjects probable or definite CAA participating in a longitudinal research study were graded for cSS presence severity (focal, restricted ≤ 3 sulci vs disseminated, ≥ 4 sulci), CMB count. APOE ε variants directly genotyped. performed cross-sectional analysis comparing counts ε2...
Cerebral microinfarcts (CMI) are important contributors to vascular cognitive impairment. Magnetic resonance imaging diffusion-weighted (DWI) hyperintensities have been suggested represent acute CMI. We aim describe a mathematical method for estimating total number of CMI based on the presence incidental DWI lesions.We reviewed magnetic scans subjects with decline, cognitively normal and previously reported past intracerebral hemorrhage (ICH). Based temporal spatial characteristics lesions,...
To identify predictors of early lobar intracerebral hemorrhage (ICH) recurrence, defined as a new ICH within 6 months the index event, in patients with cerebral amyloid angiopathy (CAA).Participants were consecutive survivors (age ≥55 years) spontaneous symptomatic probable or possible CAA-related according to Boston criteria, drawn from an ongoing single-center cohort study. Neuroimaging markers ascertained CT MRI included focal (≤3 sulci) disseminated (>3 cortical superficial siderosis...
<b><i>Background and Aims:</i></b> Systematic studies of superficial siderosis (SS) convexity subarachnoid hemorrhage (cSAH) in patients with suspected cerebral amyloid angiopathy (CAA) without lobar intracerebral (ICH) are lacking. We sought to determine the potential anatomic correlation between SS/cSAH transient focal neurological episodes (TFNE) whether is predictor future hemorrhagic events these patients. <b><i>Methods:</i></b> enrolled...
Background: Cerebral amyloid angiopathy (CAA) is increasingly recognized as a cause of cognitive impairment in the elderly, but profile patients with disease has not been well characterized. Objective: To characterize neuropsychological CAA without demen tia and to determine association between performance different domains neuroimaging lesions characteristic CAA. Methods: Fifty-eight non-demented were compared 138 cognitively normal subjects using standard test battery. Total brain volume...
To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma.