A5003038799- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience of respiration and sleep
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Pituitary Gland Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Neurosurgical Procedures and Complications
- Spinal Hematomas and Complications
- Axon Guidance and Neuronal Signaling
- Autopsy Techniques and Outcomes
- Chromatin Remodeling and Cancer
- CNS Lymphoma Diagnosis and Treatment
New York University
2017-2024
University of California, San Diego
2024
Cornell University
2024
NYU Langone Health
2016-2023
National University of Malaysia
2023
Nationwide Children's Hospital
2019
Neurological Surgery
2019
Central University of Ecuador
2018
Massachusetts General Hospital
2011-2016
Harvard University
2010-2016
The molecular mechanism involved in the process of antigen-driven somatic hypermutation Ig genes is unknown, but it commonly believed that this restricted to loci. B cell lymphomas display multiple mutations clustering 5′-regulatory region BCL-6, a proto-oncogene encoding for POZ/Zinc finger transcriptional repressor expressed germinal center (GC) cells and required GC formation. To determine whether BCL-6 represent tumor-associated phenomenon or reflect physiologic mechanism, we screened...
Soluble β-amyloid (Aβ) oligomers impair synaptic plasticity and cause loss associated with Alzheimer's disease (AD). We report that murine PirB (paired immunoglobulin-like receptor B) its human ortholog LilrB2 (leukocyte B2), present in brain, are receptors for Aβ oligomers, nanomolar affinity. The first two extracellular immunoglobulin (Ig) domains of mediate this interaction, leading to enhanced cofilin signaling, also seen AD brains. In mice, the deleterious effect on hippocampal...
Several imaging modalities are suitable for in vivo molecular neuroimaging, but the blood–brain barrier (BBB) limits their utility by preventing brain delivery of most targeted probes. We prepared biodegradable nanocarrier systems made up poly(n-butyl cyanoacrylate) dextran polymers coated with polysorbate 80 (PBCA nanoparticles) to deliver BBB-impermeable probes into neuroimaging. demonstrate that PBCA nanoparticles allow targeting contrast agents and staining reagents electron microscopy,...
In early stages of Alzheimer's disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, NFT involve widespread limbic association cortices. this point in disease, amyloid plaques also abundantly distributed cortex. This observation from human neuropathological studies led us pose two alternative hypotheses: that is permissive for spread lobe, or these co-occurring but not...
Sonic hedgehog signaling controls the differentiation of motor neurons in ventral neural tube, but intervening steps are poorly understood. A differential screen a cDNA library derived from single Shh-induced neuron has identified novel homeobox gene MNR2, expressed by progenitors and transiently postmitotic neurons. The ectopic expression MNR2 cells initiates program somatic characterized homeodomain proteins, neurotransmitter phenotype, axonal trajectory. Our results suggest that...
Anti-amyloid-b immunization leads to amyloid clearance in patients with Alzheimer's disease, but the effect of vaccination on amyloid-b-induced neuronal pathology has not been quantitatively examined.The objectives this study were address effects anti-amyloid-b active neurite trajectories and pathological hallmarks disease human hippocampus.Hippocampal sections from five enrolled AN1792 Phase 2a trial compared those 13 non-immunized Braak-stage age-matched eight non-demented...
Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, although they generally believed to be markers neuronal pathology, there is little evidence evaluating whether directly impact function. To investigate the response cells in hippocampal circuits complex behavioral stimuli, we used an environmental enrichment paradigm induce expression immediate-early gene, Arc, rTg4510 mouse model tauopathy. These mice reversibly overexpress P301L tau exhibit substantial...
Abstract Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but in pediatric patients and young adults. The variety complexity histologic subtypes can lead to diagnostic errors. DNA methylation an epigenetic modification that provides a tumor type-specific signature be used diagnosis. Methods We performed prospective study using analysis as primary method 1921 brain tumors. All tumors received pathology diagnosis profiling by...
In the developing spinal cord, motor neurons acquire columnar subtype identities that can be recognized by distinct profiles of homeodomain transcription factor expression. The mechanisms direct differentiation neuron from an apparently uniform group progenitors remain poorly defined. chick embryo,the Mnx class protein MNR2 is expressed selectively progenitors, and has been implicated in specification fate. We show here expression persists postmitotic populate median column (MMC), whereas...
To identify predictors of early lobar intracerebral hemorrhage (ICH) recurrence, defined as a new ICH within 6 months the index event, in patients with cerebral amyloid angiopathy (CAA).Participants were consecutive survivors (age ≥55 years) spontaneous symptomatic probable or possible CAA-related according to Boston criteria, drawn from an ongoing single-center cohort study. Neuroimaging markers ascertained CT MRI included focal (≤3 sulci) disseminated (>3 cortical superficial siderosis...
Amyloid-β (Aβ)-induced changes in synaptic function experimental models of Alzheimer9s disease (AD) suggest that Aβ generation and accumulation may affect fundamental mechanisms plasticity. To test this hypothesis, we examined the effect APP overexpression on a well characterized, <i>in vivo</i>, developmental model systems-level plasticity, ocular dominance Following monocular visual deprivation during critical period, mice express mutant alleles amyloid precursor protein (APPswe)...
To identify in vivo MRI markers that might correlate with cerebral microinfarcts (CMIs) on autopsy patients amyloid angiopathy (CAA).We included neuropathologic evidence of CAA and available antemortem brain MRI. Clinical characteristics CAA-related small vessel disease were recorded, including white matter hyperintensities, microbleeds, cortical superficial siderosis, centrum semiovale perivascular spaces. In addition, the presence intracerebral hemorrhage was assessed. Evaluation number...
Abstract Background Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker grade 4. We sought to investigate prognostic impact DNA methylation-derived molecular biomarkers for IDH astrocytoma. Methods analyzed 98 astrocytomas diagnosed at NYU Langone between 2014 and 2022. reviewed methylation subclass,...
Optical imaging using multiphoton microscopy and whole body near infrared has become a routine part of biomedical research. However, optical methods rely on the availability either small molecule reporters or genetically encoded fluorescent proteins, which are challenging time consuming to develop. While directly labeled antibodies can also be used as agents, species specific, typically not tagged with multiple without interfering target binding, bioactive, almost always eliciting biological...
Abstract Context X-linked acrogigantism (X-LAG), a condition of infant-onset marked by elevated GH, IGF-1, and prolactin (PRL), is extremely rare. Thirty-three cases, including three kindreds, have been reported. These patients pituitary adenomas that are thought to be mixed lactotrophs somatotrophs. Case Description The patient’s mother, diagnosed with at 21 months, underwent tumor excision 24 months. For more than 30 years, stable PRL, IGF-1 concentrations serial imaging studies indicated...
Abstract ROS1 is a transmembrane receptor tyrosine kinase proto-oncogene that has been shown to have rearrangements with several genes in glioblastoma and other neoplasms, including intrachromosomal fusion GOPC due microdeletions at 6q22.1. events are important findings these tumors, as they potentially targetable alterations newer inhibitors; however, whether tumors represent distinct entity remains unknown. In this report, we identify 3 cases of unusual pediatric glioma GOPC-ROS1 fusion....
Abstract Sudden unexplained death in childhood (SUDC) is of a child over 1 year age that after review clinical history, circumstances death, and complete autopsy with ancillary testing. Multiple etiologies may cause SUDC. SUDC sudden unexpected epilepsy (SUDEP) share pathological features, suggesting some similarities mechanism possible abnormalities hippocampus cortex. To identify molecular signaling pathways, we performed label-free quantitative mass spectrometry on microdissected frontal...
Sudden unexplained death in childhood (SUDC) affects children >1-year-old whose cause of remains following comprehensive case investigation and is often associated with hippocampal abnormalities. We prospectively performed systematic neuropathologic 20 SUDC cases, including (i) autopsy data ancillary testing, molecular studies, (ii) ex vivo 3T MRI extensive histologic brain samples, (iii) blinded neuropathology review by 2 board-certified neuropathologists. There were 12 girls 8 boys; median...
Abnormal cerebral vasculature can be a manifestation of vascular malformation or neoplastic process. We report the case patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later large intraparenchymal hemorrhage. Although imaging following was suggestive arteriovenous malformation, ultimately found to have an extensive glioblastoma associated abnormal tumor vasculature. The emphasizes need for magnetic resonance investigate SAH in suspicious cases rule...