A5017267551- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Single-cell and spatial transcriptomics
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Oral and Maxillofacial Pathology
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Ophthalmology and Eye Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- DNA Repair Mechanisms
- Management of metastatic bone disease
University of Minnesota System
2023-2025
University of Minnesota
2019-2025
University of Minnesota Medical Center
2021-2024
North American Skull Base Society
2021-2023
Twin Cities Orthopedics
2021
University of Pittsburgh Medical Center
2019-2020
Neurological Surgery
2013-2020
Oxford University Press (United Kingdom)
2020
University of Pittsburgh
2019
Massachusetts General Hospital
2011-2018
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well composition tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq 165 samples. Differences between IDH-mutant astrocytoma oligodendroglioma can be primarily explained distinct TME signature genetic events, whereas both types share similar...
Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer cells. Active human telomerase consists of at least three principal subunits, including the reverse transcriptase, RNA (TERC), dyskerin. Here, we identify holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), notably enriched bodies, nuclear sites RNP processing are important for function. associates with active enzyme, established components, small RNAs involved...
Telomerase serves a critical role in stem cell function and tissue homeostasis. This depends on its ability to synthesize telomere repeats manner dependent the reverse transcriptase (RT) of protein component telomerase RT (TERT), as well novel pathway whose mechanism is poorly understood. Here, we use TERT mutant lacking (TERT(ci)) study action mammalian skin, an ideal for studying progenitor biology. We show that TERT(ci) retains full activities wild-type enhancing keratinocyte...
Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing diagnosis by histologic analysis can be difficult in low-cellularity gliomas. Therefore, we developed a rapid and sensitive genotyping assay detect somatic single-nucleotide variants telomerase reverse transcriptase (TERT) promoter isocitrate dehydrogenase 1 (IDH1).This was applied tissue samples from 190 patients with gliomas,...
Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding the molecular features that define this response, we applied integrated, multiplatform analysis RNA profiles derived from clinically annotated glioblastoma samples. This suggested specimens responders are characterized by decreased accumulation microglia/macrophages microenvironment. Glioblastoma-associated secreted interleukin 11 (IL11) to activate STAT3-MYC signaling cells....
Telomerase supports the proliferation of progenitor cells and tumor by adding telomere repeats to chromosome ends. The low abundance restricted expression pattern telomerase have limited our knowledge this important enzyme. A new protein, TCAB1, sheds light on pathway that governs holoenzyme assembly function in vivo. TCAB1 is a component active required for accumulate Cajal bodies elongate telomeres. These findings provide insights into how functions cancer stem cell biology.
Moyamoya disease/syndrome (MMD/S) is a progressive, occlusive vasculopathy of the intracranial vasculature that leads to ischemic and hemorrhagic strokes. Significant debate exists regarding role indirect cerebrovascular bypass surgery in its management. The authors review their institution's experience with surgical management patients MMD/S.The conducted retrospective MMD/S who underwent encephaloduroarteriosynangiosis (EDAS), form bypass, from 1996 2013.A total 37 (52 hemispheres) an EDAS...
Abstract BACKGROUND Gross total resection (GTR) of contrast-enhancing tumor is associated with increased survival in primary glioblastoma. Recently, there has been increasing interest performing supratotal resections (SpTRs) for OBJECTIVE To address the published results, which have varied part due to lack consensus on definition and appropriate use SpTR. METHODS A crowdsourcing approach was used survey 21 neurosurgical oncologists representing 14 health systems nationwide. Participants were...