A5101627980- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Listeria monocytogenes in Food Safety
- Essential Oils and Antimicrobial Activity
- Genetics and Neurodevelopmental Disorders
- Cancer, Lipids, and Metabolism
- Burkholderia infections and melioidosis
- Immune cells in cancer
New York University
2024
NYU Langone Health
2024
Abstract Background Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker grade 4. We sought to investigate prognostic impact DNA methylation-derived molecular biomarkers for IDH astrocytoma. Methods analyzed 98 astrocytomas diagnosed at NYU Langone between 2014 and 2022. reviewed methylation subclass,...
Abstract Purpose: DNA methylation profiling stratifies isocitrate dehydrogenase (IDH)-mutant astrocytomas into low- and high-grade groups. We investigated the utility of T2-fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign for predicting grade cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion, a molecular biomarker 4 IDH-mutant astrocytomas, according to 2021 World Health Organization classification. Experimental Design: Preoperative MRI scans subclassified by...
<p>Supplemental Table S2. T2-weighted and FLAIR pulse sequence parameters</p>
<p>Supplemental Table S2. T2-weighted and FLAIR pulse sequence parameters</p>
<p>Supplemental Table S3. Multivariate Cox proportional hazards model for histologic grade 4 IDH-mutant astrocytomas</p>
<p>Supplemental Table S1. MRI acquisition parameters</p>
<p>Supplemental Table S4. Multivariate Cox proportional hazards model for histologic grade 2 IDH-mutant astrocytomas</p>
<p>Supplemental Table S3. Multivariate Cox proportional hazards model for histologic grade 4 IDH-mutant astrocytomas</p>
<p>Supplemental Table S1. MRI acquisition parameters</p>
<div>AbstractPurpose:<p>DNA methylation profiling stratifies isocitrate dehydrogenase (<i>IDH</i>)-mutant astrocytomas into low- and high-grade groups. We investigated the utility of T2-fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign for predicting DNA grade cyclin-dependent kinase inhibitor 2A/B (<i>CDKN2A/B</i>) homozygous deletion, a molecular biomarker 4 <i>IDH</i>-mutant astrocytomas, according to 2021 World Health...
<div>AbstractPurpose:<p>DNA methylation profiling stratifies isocitrate dehydrogenase (<i>IDH</i>)-mutant astrocytomas into low- and high-grade groups. We investigated the utility of T2-fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign for predicting DNA grade cyclin-dependent kinase inhibitor 2A/B (<i>CDKN2A/B</i>) homozygous deletion, a molecular biomarker 4 <i>IDH</i>-mutant astrocytomas, according to 2021 World Health...
<p>Supplemental Table S4. Multivariate Cox proportional hazards model for histologic grade 2 IDH-mutant astrocytomas</p>