A5005492660- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- ATP Synthase and ATPases Research
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Brain Tumor Detection and Classification
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Cerebrospinal fluid and hydrocephalus
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
New York University
2016-2025
NYU Langone Health
2015-2024
University School
2024
Case Western Reserve University
2024
University of Pennsylvania
2015-2024
University Hospitals of Cleveland
2024
University Health System
2024
Directorate-General for Interpretation
2022
Research Institute of Radiology
2021
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2020
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II III) have highly variable clinical behavior that is not adequately predicted on basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty compounded by interobserver variability in diagnosis. Mutations IDH, TP53, ATRX codeletion chromosome arms 1p 19q (1p/19q codeletion) been implicated as clinically relevant...
<h3>BACKGROUND AND PURPOSE:</h3> The World Health Organization has recently placed new emphasis on the integration of genetic information for gliomas. While tissue sampling remains criterion standard, noninvasive imaging techniques may provide complimentary insight into clinically relevant mutations. Our aim was to train a convolutional neural network independently predict underlying molecular mutation status in gliomas with high accuracy and identify most predictive features each mutation....
Purpose To conduct a comprehensive analysis of radiologist-made assessments glioblastoma (GBM) tumor size and composition by using community-developed controlled terminology magnetic resonance (MR) imaging visual features as they relate to genetic alterations, gene expression class, patient survival. Materials Methods Because all study patients had been previously deidentified the Cancer Genome Atlas (TCGA), publicly available data set that contains no linkage identifiers is HIPAA compliant,...
Abstract Purpose: Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on IDH and 1p/19q mutation status. The purpose was to investigate whether T2/FLAIR MRI features could distinguish between lower-grade glioma subtypes. Experimental Design: scans from the TCGA/TCIA lower database (n = 125) were evaluated by two independent neuroradiologists assess (i) presence/absence of homogenous signal T2WI; (ii) “T2–FLAIR mismatch” sign; (iii)...
Despite the severity of coronavirus disease 2019 (COVID-19) being more frequently related to acute respiratory distress syndrome and cardiac renal injuries, thromboembolic events have been increasingly reported. We report a unique series young patients with COVID-19 presenting cerebral venous system thrombosis. Three younger than 41 years age confirmed Severe Acute Respiratory Syndrome 2 (SARS-Cov-2) infection had neurologic findings They were admitted during short period 10 days between...
To correlate patient survival with morphologic imaging features and hemodynamic parameters obtained from the nonenhancing region (NER) of glioblastoma (GBM), along clinical genomic markers.
Abstract Background Glioma prognosis depends on isocitrate dehydrogenase (IDH) mutation status. We aimed to predict the IDH status of gliomas from preoperative MR images using a fully automated hybrid approach with convolutional neural networks (CNNs) and radiomics. Methods reviewed 1166 (grades II–IV) Severance Hospital (n = 856), Seoul National University (SNUH; n 107), The Cancer Imaging Archive (TCIA; 203). set was subdivided into development 727) internal test 129) sets. Based T1...
ObjectiveTo investigate the incidence and spectrum of neuroimaging findings their prognostic role in hospitalized COVID-19 patients New York City.MethodsThis is a retrospective cohort study 3218 confirmed admitted to major healthcare system (three hospitals) City between March 1, 2020 April 13, 2020. Clinical data were extracted from electronic medical records, particularly all neurological symptoms imaging reports. Four neuroradiologists evaluated studies for acute related...
Background and Purpose: We conducted this study to investigate the prevalence distribution of cerebral microbleeds leukoencephalopathy in hospitalized patients with coronavirus disease 2019 (COVID-19) correlate clinical, laboratory, functional outcomes. Methods: performed a retrospective chart review 4131 COVID-19 positive adult who were admitted 3 tertiary care hospitals an academic medical center at epicenter pandemic New York City from March 1, 2020, May 10, identify had magnetic...
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated two completed multisite studies. following initial radiation prior to recurrence a median overall survival of 21.7 months, whereas those after had 9.3...
Surgical decompression of metastatic epidural compression (MEC) improved ambulatory function. Spine radiosurgery can accurately target the tumor and deliver high radiation doses for control. Therefore, a clinical trial was performed to quantitatively determine degree by compression.Sixty-two patients with total 85 lesions were treated. Epidural diagnosed magnetic resonance imaging (MRI) scans. Main criteria inclusion neurological status muscle power 4 5 or better. Radiosurgery involved spine...
<b>BACKGROUND AND PURPOSE:</b> Glioma angiogenesis and its different hemodynamic features, which can be evaluated by using perfusion CT (PCT) imaging of the brain, have been correlated with grade aggressiveness gliomas. Our hypothesis was that quantitative estimation permeability surface area product (PS), cerebral blood volume (CBV), flow (CBF), mean transit time (MTT) in astroglial brain tumors PCT will correlate glioma grade. High-grade gliomas show higher PS CBV as compared low-grade...
To correlate tumor blood volume, measured by using dynamic susceptibility contrast material-enhanced T2*-weighted magnetic resonance (MR) perfusion studies, with patient survival and determine its association molecular subclasses of glioblastoma (GBM).
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. Here, we report a microfluidics-based, patient-specific ‘GBM-on-a-Chip’ microphysiological system dissect of microenvironments optimize anti-PD-1 for different GBM subtypes. Our clinical experimental analyses demonstrated that molecularly distinct subtypes have epigenetic immune signatures...
Differentiating treatment-induced necrosis (TIN) from recurrent/progressive tumor (RPT) in brain patients using conventional morphologic imaging features is a very challenging task. Functional techniques also offer moderate success due to the complexity of tissue microenvironment and inherent limitation various modalities techniques. The purpose this retrospective study was assess utility nonmodel-based semiquantitative indices derived dynamic contrast-enhanced T1-weighted MR perfusion...
Abstract AbstractThe T2-FLAIR (fluid attenuated inversion recovery) mismatch sign is an easily detectable imaging on routine clinical MRI studies that suggests diagnosis of isocitrate dehydrogenase (IDH)–mutant 1p/19q non-codeleted gliomas. Multiple independent show the has near-perfect specificity, but low sensitivity for diagnosing IDH-mutant astrocytomas. Thus, represents a non-invasive radiogenomic diagnostic finding with potential impact. Recently, false positive cases have been...