A5036177372- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- RNA Research and Splicing
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Dermatology and Skin Diseases
- Vector-borne infectious diseases
- Insect and Pesticide Research
- Gene expression and cancer classification
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Developmental Biology and Gene Regulation
- COVID-19 Clinical Research Studies
Stanford University
2016-2023
Institute for Stem Cell Biology and Regenerative Medicine
2020-2022
Stratford University
2022
California Institute for Regenerative Medicine
2016
Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via silencing. Unlike many histone modifications chromatin-associated proteins, lamina-associated domains (LADs) are mapped genome-wide in relatively few genetically normal human types, which limits our understanding role peripheral plays development disease.
Abstract Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via silencing. Unlike many histone modifications chromatin-associated proteins, lamin-associated domains (LADs) have yet be mapped genome-wide in diverse panel human types, which limited our understanding role peripheral plays development disease. To address this gap, we LAMIN B1 (LB1) across twelve...
Abstract SARS-CoV-2 is a novel respiratory virus that has quickly spread across the globe. The uses protein called Spike and its associated receptor binding domain (RBD) to interact with angiotensin converting enzyme-2 (ACE-2) on surface of epithelial cells in tract. Although definite correlate protection against COVID-19 yet emerge, many studies have quantified anti-Spike anti-RBD IgG antibody (Ab) levels, as well neutralizing Ab blood ascertain immunity. This approach misses out are...
Abstract Borrelia burgdorferi is a bacterial spirochete that can cause Lyme disease (LD) after infecting susceptible host. Immune responses to the bacteria are highly variable and host specific. The murine substrain, C3H/HeJ, frequently utilized model for LD. Interestingly, over prolonged infection, mice develop dermatitis on tail skin, which shares critical features with human skin. Female C3H/HeJ aged 5–8 weeks, 1 year, or 2 years were infected intraperitoneally 105 B. burgdorferi....