A5100409688- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Genetics and Neurodevelopmental Disorders
- Histone Deacetylase Inhibitors Research
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Rare Diseases
- RNA regulation and disease
- Insect Resistance and Genetics
- Liver physiology and pathology
- Pharmacogenetics and Drug Metabolism
- Genomics, phytochemicals, and oxidative stress
Sun Yat-sen University
2018-2025
Chinese Academy of Sciences
2015-2025
Ningbo Institute of Industrial Technology
2024-2025
St Vincent's Hospital
2012-2025
Stomatology Hospital
2025
Peking University
2025
Theranostics (New Zealand)
2025
The Kinghorn Cancer Centre
2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II III) have highly variable clinical behavior that is not adequately predicted on basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty compounded by interobserver variability in diagnosis. Mutations IDH, TP53, ATRX codeletion chromosome arms 1p 19q (1p/19q codeletion) been implicated as clinically relevant...
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique features, clinically significant subtypes, potential therapeutic targets. found 61 somatic copy-number alterations (SCNAs) 46 significantly mutated genes (SMGs). Eleven SCNAs 11 SMGs had not been identified in previous TCGA studies the individual tumor types. functionally estrogen receptor-regulated long non-coding RNAs (lncRNAs)...
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes colorectal (CRC) progression and could be potential therapeutic target. Methods We screened highly expressed lncRNAs human CRC samples compared with their matched adjacent normal tissues. The proteins interact LINRIS (Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by pull-down...
Highlights•MYC paralogs are significantly amplified (28% of all samples)•MYC antagonists mutated (MGA, 4% samples) or deleted (MNT, 10% alterations mutually exclusive with PIK3CA, PTEN, APC, BRAF alterations•Expression analysis reveals pan-cancer and tumor-specific MYC-associated pathwaysSummaryAlthough the MYC oncogene has been implicated in cancer, a systematic assessment MYC, related transcription factors, co-regulatory proteins, forming proximal network (PMN), across human cancers is...
Highlights•SCCs show chromosome or methylation alterations affecting multiple related genes•These regulate squamous stemness, differentiation, growth, survival, and inflammation•Copy-quiet SCCs have hypermethylated (FANCF, TET1) mutated (CASP8, MAPK-RAS) genes•Potential targets include ΔNp63, WEE1, IAPs, PI3K-mTOR/MAPK, immune responsesSummaryThis integrated, multiplatform PanCancer Atlas study co-mapped identified distinguishing molecular features of cell carcinomas (SCCs) from five sites...
Necrosis is one of the main forms cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types necrosis are regulated and programmed dependent on activation receptor-interacting serine/threonine-protein kinase (RIPK) 1 3 which may be negatively by Fas-associated protein with domain (FADD). In addition, microRNAs long noncoding RNAs been shown to play important roles various biological processes recently.The purpose this study was test hypothesis microRNA-103/107...
Abstract Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long noncoding RNAs (lncRNAs) in remodeling and the underlying mechanisms remain elusive. Through screening, we found that lncRNA Actin Gamma 1 Pseudogene ( AGPG ) is required increased glycolysis activity cell proliferation esophageal squamous carcinoma (ESCC). Mechanistically, binds to stabilizes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3). By preventing APC/C-mediated...
The WRKY family of transcription factors (TFs) functions as transcriptional activators or repressors in various signaling pathways. In this study, we discovered that OsWRKY62 and OsWRKY76, two genes the IIa subfamily, undergo constitutive inducible alternative splicing. full-length OsWRKY62.1 OsWRKY76.1 proteins formed homocomplexes heterocomplexes, heterocomplex dominates nuclei when analyzed Nicotiana benthamiana leaves. Transgenic overexpression rice (Oryza sativa) enhanced plant...
Abstract Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape characterize oncogenic drivers of esophageal squamous cell carcinoma (ESCC). found 98% CpGs are hypomethylated across ESCC genome. Hypo-methylated regions enriched in areas with heterochromatin binding markers (H3K9me3, H3K27me3), while hyper-methylated polycomb repressive complex (EZH2/SUZ12) recognizing regions. Altered...
Abstract Emerging evidence highlights the key regulatory roles of long noncoding RNAs (lncRNAs) in initiation and progression numerous malignancies. The lncRNA identified as differentiation antagonizing nonprotein coding RNA (DANCR) is a novel widely involved development multiple human cancers. However, function DANCR its potential molecular mechanism cervical cancer remain unclear. In this study, we discovered that was significantly elevated tissues cells, closely correlated with poor...
Abstract Long noncoding RNAs (lncRNA) are involved in tumorigenesis and drug resistance. However, the roles underlying mechanisms of lncRNAs colorectal cancer still unknown. In this work, through transcriptomic profiling analysis 21 paired tumor normal samples, we identified a novel cancer–related lncRNA, MNX1-AS1. MNX1-AS1 expression was significantly upregulated associated with poor prognosis. vitro vivo gain- loss-of-function experiments showed that promotes proliferation cells. bound to...
Esophageal squamous cell carcinoma (ESCC) is one of the most common types cancer and leading causes cancer-related mortality worldwide, especially in Eastern Asia. Here, we downloaded microarray data lncRNA expression profiles ESCC patients from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) sets divided into training, validation test set. random survival forest (RSF) algorithm Cox regression analysis were applied to identify a seven-lncRNA signature. Then predictive ability...
Background: Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, and numerous studies have demonstrated that an inflammatory environment can induce normal cells to transform into cancerous. Methods: We integrated genomic data comprehensively assess the association between pyroptosis tumor microenvironment (TME) cell-infiltrating characteristics in HCC, as well potential molecular function clinical significance of lncRNA. Results: The analysis CNV alteration frequency...
Abstract Much effort has been dedicated to developing circulating tumor cells (CTC) as a noninvasive cancer biopsy, but with limited success yet. In this study, we combine method for isolation of highly pure CTCs using immunomagnetic enrichment/fluorescence-activated cell sorting advanced whole genome sequencing (WGS), based on long fragment read technology, illustrate the utility an accurate, comprehensive, phased, and quantitative genomic analysis platform CTCs. Whole genomes 34 from...
The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (
Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators tumorigenesis tumor progression. However, roles mechanisms lncRNAs ESCC require further exploration. Here, combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS Transwell assays to screen functional that were overexpressed ESCC. TMPO-AS1...
The long noncoding RNA (lncRNA) Eosinophil Granule Ontogeny Transcript (EGOT) has been reported to inhibit the proliferation and migration of glioma cells, promote development progression gastric cancer through Hedgehog (Hh) signaling pathway. This study was conducted assess role EGOT in breast cancer. We observed that is significantly down-regulated tissues cell lines, expression negatively correlated with Ki67 expression. Overexpression BT549 cells decreased viability migration. In...
Metastasis accounts for poor prognosis of cancers and related deaths. Accumulating evidence has shown that long noncoding RNAs (lncRNAs) play critical roles in several types cancer. However, which lncRNAs contribute to metastasis colon cancer is still largely unknown. In this study, we found lncRNA LINC01578 was correlated with upregulated cancer, associated metastasis, advanced clinical stages, overall survival, disease-specific disease-free survival. Gain-of-function loss-of-function...