A5100695543- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Marine and coastal ecosystems
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Atmospheric chemistry and aerosols
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Ocean Acidification Effects and Responses
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Advanced Photocatalysis Techniques
- Gas Sensing Nanomaterials and Sensors
- FOXO transcription factor regulation
- ZnO doping and properties
- Marine Biology and Ecology Research
Ocean University of China
2015-2025
First Affiliated Hospital of Wenzhou Medical University
2019-2025
Wenzhou Medical University
2019-2025
Zhengzhou University of Light Industry
2024-2025
Westlake University
2023-2025
Institute for the Future
2025
Affiliated Hospital of Qingdao University
2020-2024
Queen's University Belfast
2024
Qingdao University
2015-2024
Shandong Eye Hospital
2022-2024
Sustained cardiac hypertrophy accompanied by maladaptive remodelling represents an early event in the clinical course leading to heart failure. Maladaptive is considered be a therapeutic target for However, molecular mechanisms that regulate are largely unknown.Here we show circular RNA (circRNA), which term heart-related circRNA (HRCR), acts as endogenous miR-223 sponge inhibit and transgenic mice developed failure, whereas miR-223-deficient were protected from hypertrophic stimuli,...
The importance of free radical homeostasis and apoptosis in normal diseased hearts their interrelationships are poorly defined. We tested whether reactive oxygen species can trigger cardiomyocytes, we explored the underlying pathways.A cell culture model isolated cardiac cells different (ROS)-generating systems were used. Apoptosis became evident when cardiomyocytes exposed to either H2O2 or superoxide anion (O2-). Both H2O2- O2--induced associated with an increase p53 protein content,...
Sustained cardiac hypertrophy is often accompanied by maladaptive remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive considered be a therapeutic target MicroRNAs (miRNAs) long noncoding RNAs (lncRNAs) have various biological functions been extensively investigated in past years.We identified miR-489 lncRNAs (cardiac related factor, CHRF) from hypertrophic cardiomyocytes. Here, we tested the hypothesis that CHRF can participate regulation of vivo...
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate the regulation heart unclear. Here we report that long RNA, named promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. results show suppresses myocardial infarction Further, find APF lncRNA regulates miR-188-3p, thus affects ATG7 expression, infarction. Our present study...
Cardiac hypertrophy is accompanied by maladaptive cardiac remodeling, which leads to heart failure or sudden death. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that mediate posttranscriptional gene silencing. Recent studies show miRNAs involved in the pathogenesis hypertrophy, but their signaling regulations remain be understood. Here, we report miR-23a pro-hypertrophic miRNA, and its expression regulated transcription factor, nuclear factor activated T cells (NFATc3). The...
miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how are integrated into apoptotic program. Mitochondrial fission is involved initiation It not yet clear whether able regulate mitochondrial fission. Here we report that miR-30 family members apoptosis by targeting machinery. Our data show can inhibit and consequent In exploring underlying molecular mechanism, identified suppress p53 expression. response stimulation, expression levels were reduced,...
Necrosis is one of the main forms cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types necrosis are regulated and programmed dependent on activation receptor-interacting serine/threonine-protein kinase (RIPK) 1 3 which may be negatively by Fas-associated protein with domain (FADD). In addition, microRNAs long noncoding RNAs been shown to play important roles various biological processes recently.The purpose this study was test hypothesis microRNA-103/107...
Background: The adult mammalian cardiomyocytes lose their proliferative capacity, which is responsible for cardiac dysfunction and heart failure following injury. molecular mechanisms underlying the attenuation of cardiomyocyte proliferation remain largely unknown. Because long noncoding RNAs (lncRNAs) have a critical role in development cardiovascular problems, we investigated whether lncRNAs any regulation repair. Methods: Using bioinformatics initial analysis, identified an lncRNA, named...
Developing bio-multifunctional wound dressings with excellent hemostasis, antibacterial, anti-inflammatory, enhanced angiogenesis and hair follicle regeneration for promoting full-thickness healing is highly valuable in clinical application. Herein, composite sponges were prepared by coupling alginate chitosan fucoidan through electrostatic interaction, Ca2+ crosslinking, lyophilization processes. The alginate/chitosan/fucoidan (ACF) display elastic properties, preserving their shape even...