A5022587302- RNA modifications and cancer
- Animal Genetics and Reproduction
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Bacillus and Francisella bacterial research
- RNA Research and Splicing
- Reproductive System and Pregnancy
- Bacterial Genetics and Biotechnology
- Muscle Physiology and Disorders
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Microbial Inactivation Methods
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Nanomaterials for catalytic reactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MXene and MAX Phase Materials
- S100 Proteins and Annexins
- Agriculture Sustainability and Environmental Impact
- Telomeres, Telomerase, and Senescence
- T-cell and Retrovirus Studies
- GABA and Rice Research
- Venous Thromboembolism Diagnosis and Management
Kaifeng City Children's Hospital
2025
University of Science and Technology of China
2023
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Beijing University of Chemical Technology
2021-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Zhejiang University
2021
Qingdao University
2020
Affiliated Hospital of Qingdao University
2020
Institute of Animal Sciences
2011-2019
Abstract The hypoxic nature of solid tumors limits the efficacy radiotherapy (RT) and leads to radiation resistance. Hypoxic radiosensitizers can enhance tumor radiosensitivity by mimicking effects oxygen, but their has been limited heterogeneous oxygen distribution in tissue. Herein, a multimodal therapeutic nanoplatform fabricated co‐encapsulation chlorin e6 tirapazamine (TPZ) with an amphiphilic polymeric conjugate cisplatin (CDDP) metronidazole is reported. This platform could kill...
The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. loss causes resistance to in colorectal (CRC) cells. Interestingly, AMER1-deficient CRC cells preferentially form distant metastases, while AMER1-naive mainly invade lymph nodes. Moreover, the inhibitor liproxstatin-1 effectively promotes hematogenous transfer Mechanistically, binds SLC7A11 ferritin light chain (FTL) recruits β-TrCP1/2, which degrade FTL by...
Cardiovascular death (CVD) represents a significant determinant affecting the long-term survival outcomes of cancer patients, independent primary tumor effects. Consequently, this study aims to identify prognostic factors in patients with bone diffuse large B-cell lymphoma (PB-DLBCL) using CVD as competing risk and develop nomogram. Data for diagnosed PB-DLBCL from 2000 2015 were sourced Surveillance Epidemiology, End Results (SEER) database total 1,224 eventually included study. The...
Human decidual natural killer (dNK) cells are a unique type of tissue-resident NK at the maternal-fetal interface. dNK likely to have pivotal roles during pregnancy, including in immune tolerance, trophoblast invasion, and fetal development. However, detailed insights into these still lacking. In this study, we performed metabolomic proteomic analyses on human derived from decidua peripheral blood. We found that 77 metabolites were significantly changed cells. Notably, compared blood (pNK)...
Microsatellite instability (MSI) is one of the hallmarks colorectal cancer (CRC). Mismatch repair (MMR) protein expression may reflect MSI status. To analyze concordance between and MMR in CRC their clinicopathological characteristics, 502 patients were retrospectively collected this study. Polymerase chain reaction-capillary electrophoresis (PCR-CE) was used to measure MSI, determined by immunohistochemistry (IHC). The causes non-concordance analyzed. Chi-square test find correlation...
Clinical radiation therapy (RT) is often hindered by the low energy absorption coefficient and hypoxic features of tumor tissues. Among tremendous efforts devoted to overcoming barriers efficient RT, application radiosensitizers cell-cycle-specific chemotherapeutics has shown great potential. However, their effectiveness compromised limited bioavailability, especially in region, which plays a major role radioresistance. Herein, simultaneously improve delivery efficacy both radiosensitizer...
Glioma (GM) is one of the major global health problems across world. Circular RNAs (circRNAs) have been increasingly identified and characterized in almost every aspect biology, especially cancer biology. This study desires to investigate mechanism circ-PITX1 on regulating GM development. Quantitative reverse-transcription polymerase chain reaction was carried out measure expression circ-PITX1, which upregulated matched cancerous tissues adjacent noncancerous from 52 patients four cell lines...
LRP6, a co-receptor for the morphogen Wnt, aids endocytosis of anthrax complexes. Here we report that Dickkopf1 (DKK1) protein, secreted LRP6 ligand and antagonist, is also modulator toxin sensitivity. shRNA-mediated gene silencing or TALEN-mediated knockout DKK1 reduced sensitivity cells to PA-dependent hybrid toxins. However, unlike solely inhibitory effect on Wnt signaling, effects overexpression toxicity were bidirectional, depending its endogenous expression cell context. Fluorescence...
Chemotherapy is one of the most commonly used clinical antitumor strategies. However, therapy-induced proliferative burst, which always accompanies drug resistance and metastasis, has become a major obstacle during treatment. Except for some endogenous cellular or genetic mechanisms microenvironmental selection pressures, intercellular connections in tumor microenvironment (TME) are also thought to be driving force acquired burst. Even though pathway inhibitors cell exempting strategies...
High-grade serous ovarian cancer (HGSOC) is a hormone-related with high mortality and poor prognosis. Based on the transcriptome of 57,444 cells in ascites from 10 patients HGSOC (including 5 pre-menopausal post-menopausal patients), we identified 14 cell clusters which were further classified into 6 types, including T cells, B NK myeloid epithelial stromal cells. We discovered an increased proportion decreased compared ascites. GO analysis revealed tumor microenvironments (TME) are closely...
Frameshift mutation in myostatin gene by zinc-finger nucleases results a significant increase muscle mass Meishan sows | Hanfang Bi, Shanshan Xie, Chunbo Cai, Lili Qian, Shengwang Jiang, Gaojun Xiao, Biao Li, Xiang Wentao Cui Agricultural Journals
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which encoded by the minus-strand of provirus, expressed in all cases ATL involved proliferation. However, exact mechanism underlying its growth-promoting activity poorly understood. Herein, we demonstrated that HBZ suppressed cyclin D1 expression inhibiting nuclear (NF)-κB signaling pathway. Among potential mechanisms...
Abstract It is technically challenging to investigate the function of secreted protein in real time by supply conditioned medium that contains interest. The internalization anthrax toxin facilitated a Dickkopf-1 (DKK1) and its receptor eventually leads cell lethality. To monitor dynamic interplay between these components live cells, we use an integrated microfluidic device perform viability assays with real-time controlled culture microenvironment parallel. Conditioned medium, which proteins...