A5103699636- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- MicroRNA in disease regulation
- Parathyroid Disorders and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- RNA Interference and Gene Delivery
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Caching and Content Delivery
- Cholesterol and Lipid Metabolism
- Metabolism, Diabetes, and Cancer
- Treatment of Major Depression
- RNA modifications and cancer
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Fibroblast Growth Factor Research
- Functional Brain Connectivity Studies
- Peroxisome Proliferator-Activated Receptors
- Suicide and Self-Harm Studies
- Satellite Communication Systems
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Schizophrenia research and treatment
Duke University
2025
Southern Medical University
2022-2024
Guangdong Provincial People's Hospital
2009-2024
Discovery Institute
2024
Sanford Burnham Prebys Medical Discovery Institute
2024
Hainan Medical University
2020-2024
Hainan General Hospital
2020-2024
Guangdong Academy of Medical Sciences
2016-2024
Sun Yat-sen University
2015-2023
Beijing Proteome Research Center
2022
Analysis of target compounds in individual small organisms is significant importance for biological, environmental, medicinal, and toxicological investigation. In this study, we reported the development a novel solid-phase microextraction (SPME) based ambient mass spectrometry (MS) method named surface-coated probe nanoelectrospray ionization (SCP-nanoESI)-MS analysis with sizes at micrometer-to-millimeter level. SCP-nanoESI-MS involves three procedures: (1) modification adsorbent surface...
Nanoparticles are attractive platforms for the delivery of various anticancer therapeutics. Nevertheless, their applications still limited by relatively low drug loading capacity and occurrence multidrug resistance (MDR) against chemotherapeutics. In this study, we report that integration d-α-tocopherol succinate (VES) residue with both chitosan paclitaxel (PTX) led to significant improvement efficiency through enhancement drug/carrier interaction. After incorporation hyaluronic acid...
The widespread use of zinc oxide nanoparticles (ZnO NPs) has resulted in their release to the environment. There been concern about ecotoxicity ZnO NPs, but little is known toxic mechanisms. In present study, we conducted acute toxicity tests show that NPs are more freshwater crustacean Daphnia pulex compared bulk or ZnSO4·7H2O. To provide an integrated and quantitative insights into isobaric tags for relative absolute quantitation (iTRAQ) proteomic analysis, which detected 262, 331, 360...
Abstract Bovine milk is rich in extracellular vesicles (mEVs) which have been suggested as a possible drug delivery vehicle with oral bioavailability. As the digestive fluids contain many lipid‐ and protein‐degrading enzymes, we explored whether mEVs given sublingually could be taken up systemically. were isolated using three different protocols, 120 nm diameter carried bovine CD81. Fluorescently stained by sublingual route detected circulation, whereas gavage at 2‐Log lower concentrations....
To examine the factor structure and psychometric properties of Patient Health Questionnaire for Adolescents (PHQ-A) in Chinese children adolescents with major depressive disorder (MDD).
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting articular joints and skeletal muscle. To assess the role of cytokines upon muscle strength in RA, we developed an vitro tissue-engineered human model (myobundle). Myobundles were generated using primary cells from vastus lateralis RA patients age-matched healthy controls. myobundles more sensitive to 5 ng/mL IFN-γ, exhibiting reduced contractile force altered contraction kinetics. Addition IL-6 with or without IFN-γ led...
Skeletal muscle disease in patients with early-stage rheumatoid arthritis (RA) is understudied. The objective of this study was to identify whether early RA (symptoms <6 months) have impaired skeletal health. Participants (n = 10) and age-, sex-, BMI-matched healthy controls underwent cross-sectional clinical, physiological, biomechanical property assessments. Upper lower extremity muscles vivo passive property-tone, stiffness, elasticity-assessments via myotonometry (MyotonPro®). In vitro...
Despite widespread acknowledgment of the impact stressful life events on suicide risk, understanding psychological mechanisms underlying relationship between and risk in major depressive disorder (MDD) remain unclear. This study aim to examine whether distress tolerance mediates patients with MDD.A cross-sectional was carried out among 125 Chinese MDD, mean age 27.05 (SD=0.68) 68.8% were females. The 17-item Hamilton Depression Rating scale (HAMD-17), validated version Mini International...
Vascular calcification (VC), a major complication in chronic kidney disease (CKD), is predominantly driven by osteoblastic differentiation. Recent studies have highlighted the crucial role of microRNAs CKD's pathogenesis. Here, our research focused on effects miR-204-5p and its molecular mechanisms within VC. We initially found notable decrease levels human aortic vascular smooth muscle cells stimulated with inorganic phosphate, using this as VC model vitro. Following overexpression...
Abstract MYOD is an E-box sequence-specific basic Helix-Loop-Helix (bHLH) transcriptional activator that, when expressed in non-muscle cells, induces nuclear reprogramming toward skeletal myogenesis by promoting chromatin accessibility at previously silent loci. Here, we report on the identification of a unrecognized property as repressor gene expression, via E-box-independent binding within accessible genomic elements, which invariably leads to reduced accessibility. MYOD-mediated...
To date no study has compared more specifically the psychotropic medication treatment patterns for patients with schizophrenia living in community between rural and urban areas. This examined rural-urban differences of use drugs among community-dwelling individuals China.Data on 993 (n = 479 area n 514 area) were collected by interviews during 2013-2014, 2015-2016 according to diagnosis DSM-IV or ICD-10. Data patients' socio-demographic clinical characteristics, prescriptions using a...
Chemotherapy is one of the most commonly used clinical antitumor strategies. However, therapy-induced proliferative burst, which always accompanies drug resistance and metastasis, has become a major obstacle during treatment. Except for some endogenous cellular or genetic mechanisms microenvironmental selection pressures, intercellular connections in tumor microenvironment (TME) are also thought to be driving force acquired burst. Even though pathway inhibitors cell exempting strategies...
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features had cough yellow phlegm for 1 month described. Pulmonary computed tomography (CT) scanning 18F-fluorodeoxyglucose positron emission combined CT identified two different lesions in mediastinum pulmonary region, respectively. The...
Coronary artery calcification (CAC) is a common complication in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (MHD), and the extent of CAC predominant predictor cardiovascular outcomes MHD patients. In this study, we sought to uncover relationship between circulating miRNA-29b, sclerostin levels, CAC, events (CVEs) patients.This study recruited receiving for at least three months Hainan General Hospital January 2016 June 2019, all were followed up 24 CVEs. The...
Inflammation of the small intestine may occur in type 2 diabetes. This study aimed to investigate whether ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) were altered chronic inflammation diabetic rats. Thirty-two male Sprague-Dawley rats used. Eight control group fed with regular chow, 24 a high-fat diet injected single low dose streptozotocin. All bred for 10 months. Immunohistochemistry detected ABCA1 ABCG1 all Hematoxylin-eosin staining showed that alteration was different...
Aarskog(-Scott) syndrome (AAS) is characterized by short stature, and facial, limb, genital anomalies. AAS can be an X-linked condition caused mutations in the FGD1 gene, but there evidence that autosomal dominant or recessive form also exists. We report on a Chinese family whom several members have manifestations of AAS, differ limb anomalies show additional characteristics. sequencing linkage analysis excluded as cause this family. A common known submicroscopic chromosome imbalance less...