A5060677592- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Exercise and Physiological Responses
- Myofascial pain diagnosis and treatment
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Viral Infections and Immunology Research
- Heart Rate Variability and Autonomic Control
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Mobile Health and mHealth Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tendon Structure and Treatment
- Immune Cell Function and Interaction
- Musculoskeletal pain and rehabilitation
- Galectins and Cancer Biology
- Mycobacterium research and diagnosis
- Tryptophan and brain disorders
- Elbow and Forearm Trauma Treatment
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Peripheral Nerve Disorders
- Dietary Effects on Health
- Psoriasis: Treatment and Pathogenesis
Duke University
2018-2025
Durham VA Medical Center
2023
LabCorp (United States)
2023
KU Leuven
2021
Center for Rheumatology
2021
Duke Medical Center
2016-2020
Illinois College
2011-2015
University of Illinois Chicago
2012
University of Illinois Urbana-Champaign
2011
To identify molecular alterations in skeletal muscle rheumatoid arthritis (RA) that may contribute to ongoing disability RA.Persons with seropositive or erosive RA (n = 51) and control subjects matched for age, gender, race, body mass index (BMI), physical activity underwent assessment of disease activity, disability, pain, thigh biopsies. Muscle tissue was used measurement pro-inflammatory markers, transcriptomics, comprehensive profiling metabolic intermediates. Groups were compared using...
Abstract Background Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, muscle molecular pathways may contribute. The purpose of this study was to identify connections between pathways, RA activity, and improvements following HIIT. Methods assessments vastus lateralis biopsies were performed in two separate cohorts persons with established,...
Skeletal muscle disease in patients with early-stage rheumatoid arthritis (RA) is understudied. The objective of this study was to identify whether early RA (symptoms <6 months) have impaired skeletal health. Participants (n = 10) and age-, sex-, BMI-matched healthy controls underwent cross-sectional clinical, physiological, biomechanical property assessments. Upper lower extremity muscles vivo passive property-tone, stiffness, elasticity-assessments via myotonometry (MyotonPro®). In vitro...
Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we measured changes inter-relationships plasma galectin-3, skeletal cytokines, myostatin patients RA prediabetes before after a high-intensity interval (HIIT) program. Previously sedentary persons either (n = 12) or 9) completed 10-week supervised HIIT At...
Cardiopulmonary Exer cise Testing (CPET) is a unique physiologic medical test used to evaluate human response progressive maximal exercise stress. Depending on the degree and type of deviation from normal response, CPET can help identify patient's specific limitations guide clinical care without need for other expensive invasive diagnostic tests. However, given amount complexity data obtained CPET, interpretation visualization results challenging. currently require dedicated training...
Abstract Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic metabolism) and thus may impact RA cell function. In this pilot study of participants, we took advantage heterogeneous responses to a high-intensity interval (HIIT) exercise program identify relationships between improvements in with changes peripheral skeletal muscle 12 previously sedentary...
Ankylosing spondylitis (AS) is not fully explained by inflammatory processes. Clinical, epidemiological, genetic, and course of disease features indicate additional host-related risk processes predispositions. Collectively, the pattern predisposition to onset in adolescent young adult ages, male preponderance, widely varied severity AS unique among rheumatic diseases. However, this could reflect biomechanical structural differences between sexes, naturally occurring musculoskeletal changes...
Background: MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA), obesity, and altered metabolism. Although RA is associated with both obesity metabolism, expression RA-related microRNA setting these cardiometabolic comorbidities unclear. Our objective was to determine relationships between six microRNAs disease activity, inflammation, body composition metabolic function. Methods: Expression plasma miR-21, miR-23b, miR-27a, miR-143, miR-146a, miR-223 measured 48...
RA, even when controlled, is associated with skeletal muscle weakness and greater risk of cardiovascular disease (CVD). Using exercise as a therapeutic against, the progression RA often avoided due to fear worsening pathology. We introduce K/BxN mouse an model study both myocardial dysfunction. show that endurance can improve joint, cardiac, function in mice, suggesting may be beneficial for patients RA.
Objective To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, activity, patient‐reported outcomes in older patients with rheumatoid arthritis (RA) overweight/obesity. Methods Twenty (60–80 years), previously sedentary participants seropositive RA overweight/obesity were randomized 16 weeks of either Supervised Weight Exercise Training (SWET) or Counseling Health As Treatment (CHAT). The SWET group...
Introduction: Individuals with rheumatoid arthritis (RA) have an increased risk for cardiometabolic disease. By improving traditional markers of health, interventions that induce weight loss and increase physical activity may also reduce RA-related disease risk. However, to achieve these health benefits, individual must adhere such interventions. To understand whether sustained behavioral modification is feasible individuals RA, assessing adherence prescribed intervention components needed....