A5100389324- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Vascular Malformations and Hemangiomas
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Microfluidic and Bio-sensing Technologies
- Vascular Malformations Diagnosis and Treatment
- Circular RNAs in diseases
- Nanopore and Nanochannel Transport Studies
- RNA modifications and cancer
- Oral and Maxillofacial Pathology
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Salivary Gland Disorders and Functions
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Rhetoric and Communication Studies
Wuhan University
2016-2025
Harbin Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2022-2024
Guangxi Medical University
2022-2024
Zhengzhou University of Light Industry
2023-2024
Huazhong Agricultural University
2023
Wenzhou Medical University
2017-2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Jiaxing University
2022-2023
Abstract Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting deubiquitinase, USP8, significantly enhances efficacy of anti-PD-1/PD-L1 through reshaping an inflamed tumor microenvironment (TME). Mechanistically, USP8 inhibition increases PD-L1...
Cell-derived microvesicles (MVs) are natural carriers that can transport biological molecules between cells, which expected to be promising delivery vehicles for therapeutic purposes. Strategies label MVs very important investigation and application of MVs. Herein, ultrasmall Mn-magnetofunctionalized Ag2Se quantum dots (Ag2Se@Mn QDs) integrated with excellent near-infrared (NIR) fluorescence magnetic resonance (MR) imaging capabilities have been developed instant efficient labeling their in...
Cell-derived microvesicles (MVs), which are biogenic nanosized membrane-bound vesicles that convey bioactive molecules between cells, have recently received attention for use as natural therapeutic platforms. However, the medical applications of MV-based delivery platforms limited by lack effective methods efficient isolation MVs and convenient tuning their targeting properties. Herein, we report development magnetic folate (FA)-modified based on a donor cell-assisted membrane modification...
Nickel compounds are carcinogenic to humans, possibly through induction of reactive oxygen species (ROS) that damage macromolecules including DNA and proteins. The aim the present study is elucidate role ROS-mediated Akt/apoptosis-regulating signal kinase (ASK) 1/p38 pathway in nickel-induced apoptosis. Exposure human bronchial epithelial cells (BEAS-2B) nickel induced generation ROS activation Akt associated with ASK1 p38 mitogen-activated protein kinase. Immunoblotting suggested a...
Resistance to chemotherapy remains a major obstacle for the effective treatment of oral squamous cell carcinoma (OSCC). Evidence involvement exosomes as important regulators cisplatin chemoresistance in OSCC is still poorly understood. Our objective this study was explore roles modulating key cellular pathways mediating response chemotherapy. We first developed cisplatin-resistant lines (HSC-3-R and SCC-9-R) found that conditioned media from cells enhanced parental cell. The release blocked...
Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake lactate production, termed as aerobic glycolysis. Targeting glycolysis presents promising strategy for cancer therapy. This study investigates the therapeutic potential of blockage targeting phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) in HNSCC. 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one (PFK15) was used selective antagonist...
Abstract Hepatoblastoma is the most common liver tumor of early childhood, which usually characterized by unusual hypervascularity. Recently, long non-coding RNAs (lncRNA) have emerged as gene regulators and prognostic markers in several cancers, including hepatoblastoma. We previously reveal that lnRNA-TUG1 upregulated hepatoblastoma specimens microarray analysis. In this study, we aim to elucidate biological clinical significance TUG1 upregulation show significantly human metastatic cell...
Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord are essential causes of death long-term disability difficult to cure, mainly due the limited neuron regeneration glial scar formation. Herein, we apply extracellular vesicles (EVs) secreted by M2 microglia improve differentiation neural stem cells (NSCs) at injured site, simultaneously modify them with vascular targeting peptide (DA7R) cell recruiting factor (SDF-1) on their surface via...
Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed investigate whether endothelial mesenchymal transition (EndoMT) contributes therapeutic effects BLM.Endothelial and markers HUVECs were measured by immunofluorescence, real-time quantitative PCR Western blot analysis. Cell migration tube formation assays performed evaluate cell function. Slug small-interfering RNA specific inhibitors [Z-VAD-FMK for pan...
Extracellular vesicles (EVs) are cell-derived membrane-enclosed structures that deliver biomolecules for intercellular communication. Developing visualization methods to elucidate the spatiotemporal dynamics of EVs' behaviors will facilitate their understanding and translation. With a quantum dot (QD) labeling strategy, single particle tracking (SPT) platform is proposed here dissecting dynamic EVs. The interplays between tumor small EVs (T-sEVs) endothelial cells (ECs) specifically...
Abstract Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different pathways as well interaction pattern molecules carried on circulating small extracellular vesicles (sEV) might contribute to the low response rate. Here we demonstrate that PD-1 and CD80 immunocyte-derived sEVs (I-sEV) induce an adaptive redistribution PD-L1 in tumour cells. The resulting decreased cell membrane expression increased sEV secretion into...
Liquid biopsy is of great significance in tumor early diagnosis and treatment stratification. PD-L1-positive small extracellular vesicles (PD-L1+ sEVs) are closely related to growth immunotherapy response, which considered valuable liquid biomarkers. In contrast conventional vitro detection, vivo detection has the ability improve efficiency enable continuous or real-time dynamic monitoring. However, PD-L1+ sEVs multiple difficulties, such as high cell background, complex blood environments,...
PD-L1-positive extracellular vesicles (PD-L1