A5078591256- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Oral Health Pathology and Treatment
- Extracellular vesicles in disease
- Dermatologic Treatments and Research
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Skin and Cellular Biology Research
- Genetic Syndromes and Imprinting
- Silk-based biomaterials and applications
- Oral and Maxillofacial Pathology
- Erythrocyte Function and Pathophysiology
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- melanin and skin pigmentation
- Craniofacial Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Hair Growth and Disorders
- Genomics, phytochemicals, and oxidative stress
- Reconstructive Surgery and Microvascular Techniques
- Skin Protection and Aging
- TGF-β signaling in diseases
- Temporomandibular Joint Disorders
Wuhan University
2015-2025
Bose Institute
2002-2014
Cleveland Clinic
1994
Cell-derived microvesicles (MVs), which are biogenic nanosized membrane-bound vesicles that convey bioactive molecules between cells, have recently received attention for use as natural therapeutic platforms. However, the medical applications of MV-based delivery platforms limited by lack effective methods efficient isolation MVs and convenient tuning their targeting properties. Herein, we report development magnetic folate (FA)-modified based on a donor cell-assisted membrane modification...
Abstract Background Alterations in intercellular communication driven by cellular senescence constitute an important factor skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates communication; however, the relationship between and migrasomes remains unreported. Objective This study aims to explore possible formation, investigate effects of young fibroblast-derived on senescent keratinocytes wound healing aged skin. Result Single-cell RNA sequencing...
Basic fibroblast growth factor (bFGF) stimulates migration and proliferation of vascular endothelial cells (EC). Fibroblast (FGF) receptors have an intrinsic tyrosine kinase activity involved in FGF-mediated proliferation, but the signal transduction pathway(s) responsible for movement is not known. We compared role signal-transducing G-proteins migratory proliferative responses bovine aortic EC vitro. Pertussis toxin, which ADP-ribosylates susceptible G-proteins, reduced bFGF-stimulated by...
The most common alterations found in breast cancer are inactivation or mutation of tumor suppressor gene p53. present study revealed that theaflavins induced p53- mutated human cell apoptosis. Pharmacological inhibition caspase-8 expression dominant-negative (Dn)-caspase-8/Fas-associated death domain (FADD) partially inhibited apoptosis, whereas caspase-9 inhibitor completely blocked the killing indicating involvement parallel pathways converged to mitochondria. Further studies demonstrated...
Endothelial cell (EC) migration is a regulatory event in the formation and repair of blood vessels. Although serum contains substantial promigratory activity, responsible components especially role lipoproteins have not been determined. We examined effect plasma high-density lipoprotein (HDL) on movement ECs vitro. Confluent cultures bovine aortic serum-free medium were "wounded," was measured after 24 hours. HDL stimulated concentration-dependent manner with half-maximal response at 25 to...
The application of computer-assisted design and manufacturing (CAD/CAM) technology digital guides has made maxillofacial defect reconstruction surgery faster, more convenient, precise, highly accurate in restoration. However, addressing for patients with skeletal malocclusion, the restoration facial contours received less attention, surgical planning such cases remains challenging. In this study, we report a case where deep integration orthognathic concepts was applied. patient presented an...
With the existing knowledge of ATM's role in therapeutic resistance, present study aimed at identifying molecular mechanisms that influence ATM to oscillate between chemoresistance and chemosensitivity. We observed redox status tumors functions as a major determinant ATM-dependent 'resistance-to-apoptosis' switch. At low reactive oxygen species (ROS) condition during genotoxic insult, ATM/sumoylated-IKKγ interaction induced NFκB activation resisted JNK-mediated apoptosis, whereas increasing...
<title>Abstract</title> Migrasomes are newly discovered organelles with demonstrated functions in organ morphogenesis and angiogenesis. However, the effect of migrasomes tissue repair remains unreported. Our transmission electron microscopy findings revealed that were directly connected retraction fibers could release their contents into surroundings human rat skins oral mucosae. Multiplex immunofluorescence staining results these originated from fibroblasts. Live-cell imaging mucosal...
An organoid culture system better recapitulates the cellular structure, function, and interaction between cells extracellular matrix (ECM) than a two-dimensional (2D) system. We here constructed condylar cartilage to explore regulatory role of primary cilia. Similar natural cartilage, exhibited abundant ECM comprised superficial, proliferative, hypertrophic zones. Primary cilia in were shorter on average those 2D chondrocytes, but their length was equivalent cartilage. Notably, each zone had...
Developing a dual-function skin-stretching device is beneficial for skin mechanotransduction analysis and wound healing applications. In this study, was designed based on three-dimensional (3D) printing, which can be fixed rat stretching tension-relieving tests. During the assay, piece of pulled outward by applying mechanical load, magnitude could studied force analysis. edges to opposite side accelerate closure. The exert forces varying magnitudes (0.0042–0.0113 N) skin, leading variations...
Rete ridges play a critical role in maintaining epidermal structure and mechanical properties. Notably, rete can be divided into three compartments: the base, slope tip. The present study aims to explore whether these compartments have distinct adhesive functions. We collected 28 normal masticatory mucosae prepare paraffin-embedded sections. Immunohistochemistry immunofluorescent staining were used analyse expression pattern of integrin α6 β4 different ridges. To observe had forces,...