A5081922105- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Bioactive Compounds and Antitumor Agents
- Ultrasound and Hyperthermia Applications
- Hydrogen's biological and therapeutic effects
- Lanthanide and Transition Metal Complexes
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Cancer, Lipids, and Metabolism
- 3D Printing in Biomedical Research
- Reproductive System and Pregnancy
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Chemokine receptors and signaling
- Cancer Research and Treatments
- Advanced Proteomics Techniques and Applications
- Nanoplatforms for cancer theranostics
- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
Indian Institute of Science Education and Research Kolkata
2024-2025
Techno India University
2024
Bose Institute
2011-2019
Bankura Sammilani Medical College
2016
University of California, Davis
2015-2016
National Cancer Institute
2013
Nuclear factor kappa beta (NF-κB) plays a pivotal role in breast cancer, particularly triple-negative by promoting inflammation, proliferation, epithelial–mesenchymal transition, metastasis, and drug resistance. Upregulation of NF-κB boosts vascular endothelial growth (VEGF) expression, assisting angiogenesis. The Ru(II) complexes methyl- dimethylpyrazolyl-benzimidazole N,N donors inhibit phosphorylation ser536 p65 translocation the heterodimer (p50/p65) to nucleus, disabling transcription...
A fluorogenic competitive enzyme inhibitor emitting in the visible range enables assays to screen new potential inhibitors of target (ALDH1A1) by displacement method, providing kinetic parameters and more. We intro-duce first ALDH1A1 synthesized combining a fluorescent napthalimide derivative with an isatin motif. Isatin derivatives are known bind strongly substrate binding site, allowing broad win-dow for future modifications. The presented compound competes enzyme-substrate evaluation...
With the existing knowledge of ATM's role in therapeutic resistance, present study aimed at identifying molecular mechanisms that influence ATM to oscillate between chemoresistance and chemosensitivity. We observed redox status tumors functions as a major determinant ATM-dependent 'resistance-to-apoptosis' switch. At low reactive oxygen species (ROS) condition during genotoxic insult, ATM/sumoylated-IKKγ interaction induced NFκB activation resisted JNK-mediated apoptosis, whereas increasing...
Expression microdissection (xMD) is a high-throughput, operator-independent technology that enables the procurement of specific cell populations from tissue specimens. In this method, histological sections are first stained for cellular markers via either chemical or immuno-guided methods, placed in close contact with an ethylene vinyl acetate (EVA) film, and exposed to light source. The focal, transient heating cells subcellular structures melts EVA film selectively targets procurement....
The Warburg effect, which generates increased demand of glucose in cancer cells is a relatively underexplored phenomenon existing commercial drugs to enhance uptake cells. Here, we present chemotherapeutic strategy employing Ru(II)-bis-bipyridyl-morphocumin complex (2) encapsulated self-assembling glucose-functionalized copolymer P(G-EMA-co-MMA) (where G=glucose; MMA=methyl methacrylate; EMA=ethyl methacrylate), designed exploit this effect for enhanced selectivity treatment. polymer,...