A5056225579- Viral Infections and Vectors
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Genomics, phytochemicals, and oxidative stress
- Mesenchymal stem cell research
- Medical Research and Treatments
- Birth, Development, and Health
- Pesticide Residue Analysis and Safety
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- Advanced Fiber Laser Technologies
- PI3K/AKT/mTOR signaling in cancer
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Platelet Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Acute Myeloid Leukemia Research
- NF-κB Signaling Pathways
- Insect symbiosis and bacterial influences
Hubei University of Science and Technology
2013-2025
Zhejiang Chinese Medical University
2018-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Chengde Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Wuhan University
2014-2023
Wuhan Institute of Virology
2017-2023
Changhai Hospital
2023
Although AMP-activated protein kinase (AMPK) has been extensively studied in cellular processes, the understanding of its substrates, downstream functions, contributions to cell fate and colorectal cancer (CRC) progression remains incomplete.
Breast cancer is the most common malignancy in world, particularly affecting female patients. Enhancing therapeutic strategies for breast necessitates identifying molecular drug targets that effectively eliminate tumor cells. One of these prominent forkhead and O3a class (FOXO3a), a member transcription factor subfamily. FOXO3a plays pivotal role various cellular processes, including apoptosis, proliferation, cell cycle regulation, resistance. It acts as suppressor multiple types, although...
Lycorine has been revealed to inhibit the development of many kinds malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine's inhibition on cancers through some peripheral mechanism, in-depth mechanism studies Lycotine's anti-GBM effects still call for further exploration. Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are most common oncogenic events in GBM. Targeting EGFR by small molecular inhibitors is a...
The aim of this study was to assess the effect low maternal weight at pre-pregnancy and average gestational gain on undernourished children their intellectual development. From October 2012 September 2013, we followed 1744 offspring women who participated in a trial conducted from 2002 2006. Pregnant recruited original could receive three prenatal health checks for free, which height were measured. WISC-IV used estimate development children. Weight both pregnant measured by trained...
The present study aims to investigate the efficacy and mechanisms of peroxisome proliferator-activated receptor γ coactivator 1-α agonist, as adjuvant programmed death-1 (PD-1) blockade in hyporesponsive lung cancer cells-derived vivo tumor model, using bezafibrate.Mouse Lewis carcinoma (LLC) xenograft models were established treated with death-ligand 1 (PD-L1) monoclonal antibodies or without bezafibrate. Tumors peripheral blood mice harvested quality, quantity, function well energetic...
Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important in vitro pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO predominantly extracted from Hippophae rhamnoides L . This plant well-known China abroad because of its “medicinal food homologous” characteristics. As noteworthy natural drug candidate, has received considerable attention recent years owing low cost, wide availability, high efficacy, toxicity,...
// Haowen Xiao 1, 2, * , Li-Mengmeng Wang Yi Luo Xiaoyu Lai 1 Caihua Li 3 Jimin Shi Yamin Tan Shan Fu Yebo Ni Zhu Jingsong He Weiyan Zheng Xiaohong Yu Zhen Cai Huang Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P R China 2 Department Hematology, Guangzhou General Hospital Military Command (Guangzhou Liuhuaqiao Hospital), Guangzhou, Center for Genetic and Genomic Analysis, Genesky Biotechnologies Inc., Shanghai, These...
In the cell cycle, cyclin-dependent kinases (CDKs) play a positive regulatory role, which is essential for normal growth, but expression pattern and prognostic significance of CDK family in colorectal cancer (CRC) have not been systematically investigated.In our study, we analyzed visualized CDKs CRC using TCGA, GEPIA, GSCALite, TIMER, HPA database, R language risk model was constructed.Overall, (CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7 CDK8) were differentially expressed between controls...
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In order to provide some references for vein approach selection in adrenal sampling (AVS), this retrospective study analyzed 325 cases of primary aldosteronism (PA) patients who underwent AVS via the upper extremity approach, comparing differences complications and visual analogue scale (VAS) scores through median cubital (MCV), basilic (BV), cephalic (CV). The results indicated no significant difference incidence venous spasm (right MCV vs. right BV left BV: 4.2 5.9 5.3 0.0%, p>0.05) VAS...
Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing prevalence worldwide. Naringenin (NAR) has been proven effective in preventing UC, but its mechanism not fully elucidated. In this study, network pharmacology and bioinformatics methods are used to screen the genes associated NAR UC. A mouse model of dextran sulfate sodium (DSS)-induced UC established. After treatment NAR, activity index (DAI) scored, colonic histopathology observed via hematoxylin-eosin (HE)...
ABSTRACT This study investigates the association of father–child and mother–child relationships with aggression in Chinese adolescents mediating role psychological suzhi, considering gender differences. Conducted over three measurements between September 2022 April 2024, involved 744 (53.2% boys; age at T1 M = 12.89, SD 0.80). Findings showed that both were directly associated adolescent after one a half years indirectly mediated by suzhi. However, direct was not significant male female...
Endocrine diseases are suspected contributors to lymphoid malignancies, but their precise association is unclear. This study aimed investigate the causal relationship between various endocrine diseases-specifically type 2 diabetes, obesity, diabetic hypoglycemia, hyperlipidemia, and hyperthyroidism-and including lymphocytic leukemia non-Hodgkin's lymphoma with subtypes like diffuse large B-cell follicular lymphoma. Utilizing data from genome-wide studies, a two-sample Mendelian randomization...
Heat shock proteins (Hsps) play important roles in the environmental adaptation of various organisms. To explore functions Hsps relation to heat stress and development Cotesia vestalis, a solitary larval endoparasitoid Plutella xylostella, four protein genes, CvHsp40, CvHsc70, CvHsp70 CvHsp90, were cloned sequenced from C. vestalis by real-time quantitative PCR RACE. The cDNA sequence CvHsp90 1473 bp, 2316 2279 bp 2663 long, which encode with calculated molecular weights (MW) 39.1 kDa, 71.2...
Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a novel tumor suppressor gene that critical for regulating cell invasion and metastasis. The expression of RECK dramatically down-regulated in human cancers. Harmine, tricyclic compound from Peganum harmala, has been shown to have potential anti-cancer activity.Cell proliferation assay (CCK-8 viability assay), cycle analysis (detection by flow cytometry), apoptosis staining (TUNEL staining), migration (transwell assay) were...
The aim of this study was to evaluate the effect prenatal and postnatal malnutrition on intellectual functioning early school-aged children. We followed offspring women who had participated in a trial supplementation with different combinations micronutrients remained resident field. measured their using Wechsler intelligence scale for children (WISC-IV). Height-for-age, weight-for-age, body mass index (BMI)-for-age were used as anthropometric nutritional status indices. Four 5 composite...