A5100410131- Blood Pressure and Hypertension Studies
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Health and Disease Prevention
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Cancer Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Cardiovascular Health and Risk Factors
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Pancreatic and Hepatic Oncology Research
- Sodium Intake and Health
- Spinal Fractures and Fixation Techniques
- Cardiac Health and Mental Health
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Computational Drug Discovery Methods
- Skin and Cellular Biology Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Healthcare and Venom Research
Sichuan University
2017-2025
BGI Research
2025
BGI Group (China)
2025
West China Hospital of Sichuan University
2017-2025
Beijing Graphene Institute
2025
Hubei University of Science and Technology
2013-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangxi Provincial People's Hospital
2024
South China Normal University
2024
Shanghai Electric (China)
2024
The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. new responsible for this outbreak—severe acute respiratory syndrome 2 (SARS-CoV-2)—shares high sequence identity SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the reservoir host variety coronaviruses3,4, it remains unknown whether SARS-CoV-2 has additional species. Here we show that which name pangolin-CoV, isolated from Malayan pangolin 100%, 98.6%, 97.8% 90.7% amino...
Abstract The outbreak of 2019-nCoV in the central Chinese city Wuhan at end 2019 poses unprecedent public health challenges to both China and rest world 1 . new coronavirus shares high sequence identity SARS-CoV a newly identified bat 2 While bats may be reservoir host for various coronaviruses, whether has other hosts is still ambiguous. In this study, one isolated from Malayan pangolins showed 100%, 98.2%, 96.7% 90.4% amino acid with E, M, N S genes, respectively. particular,...
Abstract Bile salt hydrolase (BSH) in Bacteroides is considered a potential drug target for obesity-related metabolic diseases, but its involvement colon tumorigenesis has not been explored. BSH-expressing found at high abundance the stools of colorectal cancer (CRC) patients with overweight and feces high-fat diet (HFD)-induced CRC mouse model. Colonization B. fragilis 638R, strain low BSH activity, overexpressing recombinant bsh gene from NCTC9343 strain, results increased unconjugated...
ABSTRACT Rhinolophus bats have been identified as natural reservoirs for viruses with global health implications, including severe acute respiratory syndrome–related coronaviruses (SARSr‐CoV) and swine diarrhoea syndrome‐related coronavirus (SADSr‐CoV). In this study, we characterised the individual viromes of 603 to systematically investigate diversity, abundance geographic distribution viral communities within R. affinis , sinicus 11 other bat species. The massive metatranscriptomic data...
Systemic immune inflammatory index (SII) and systemic response (SIRI) are combinations of non-specific adaptive impairments associated with cardiovascular disease. Yet little analysis has been done on SII, SIRI acute myocardial infarction (AMI) prognosis. The purpose this study was to investigate the correlation SII clinical risk factors such as GRACE, Gensini, QTc after infarction.This enrolled 310 patients AMI from February 1, 2018, December 31, 2022, at our institution. Routine blood...
Abstract Background The hemoglobin glycation index (HGI) is the difference between observed and predicted values of glycosylated (HbA1c), which closely associated with a variety poor prognoses. However, there are still no studies on correlation HGI prognosis in patients critical coronary artery disease. purpose this study was to analyze all-cause mortality disease using MIMIC-IV database. Methods calculated by constructing linear regression equation HbA1c fasting plasma glucose (FPG). A...
Background and AimsObesity insulin resistance are associated with left ventricular diastolic dysfunction (LVDD) increased risk of heart failure.Cardiometabolic index (CMI) triglyceride glucose (TyG) new indexes to assess visceral obesity resistance, respectively.The study aimed investigate the clinical usefulness these for identifying LVDD individuals. Methods ResultsOverall, 1898 asymptomatic individuals were included in this cross-sectional study.Participants underwent anthropometrics,...
A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment AD. Most these compounds exhibited strong clearly selective inhibition to eeAChE. Among them, compound 4c was identified most potent inhibitor both eeAChE hAChE (IC50 = 0.22 μM eeAChE; IC50 0.16 hAChE), it also best AChE-induced Aβ aggregation (29.02% at 100 μM) an efficient self-induced (30.67% 25 μM). Kinetic molecular modelling studies...
Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important in vitro pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO predominantly extracted from Hippophae rhamnoides L . This plant well-known China abroad because of its “medicinal food homologous” characteristics. As noteworthy natural drug candidate, has received considerable attention recent years owing low cost, wide availability, high efficacy, toxicity,...
Abstract Background The metabolic syndrome (Mets) is a multiplex risk factor for atherosclerotic cardiovascular diseases. aims of the study were to assess association Mets with TyG index and TyG-related parameters in an urban Chinese population. Methods data collected 1992 then again 2007 from same group 590 individuals (363 males 227 females) without 1992. fasting lipid profile blood glucose measured. related calculated, defined according harmonized criteria. area under curve (AUC) receiver...
Osteochondral allograft transplantation (OCA) treats symptomatic focal cartilage defects with satisfactory clinical results.To comprehensively analyze the characteristics and outcomes of OCA for treating articular defects.Systematic review; Level evidence, 4.We searched Embase, PubMed, Cochrane Database, Web Science studies published between January 1, 2001, December 31, 2020, on defects. Publication information, patient data, osteochondral storage details, were extracted to conduct a...
Rheumatoid arthritis (RA) is a complicated chronic disorder of the immune system, featured with severe inflammatory joints, synovium hyperplasia, articular cartilage, and bone damage. In RA microenvironment, RA-involved cells, overproduced nitric oxide (NO), pro-inflammatory cytokines are highly interplayed mutually reinforced, which form vicious circle play crucial roles in formation progression RA. To comprehensively break obtain maximum benefits, we have developed neutrophil...
Quantitative MRI of the hippocampus has been increasingly employed as a biomarker in Alzheimer's disease (AD). We compare voxel-based morphometry (VBM) standard and DARTEL registration with manual hippocampal volumetry AD patients cognitively
Abnormal metabolism of cholesterol may be a contributing factor in nonalcoholic steatohepatitis (NASH) pathogenesis. Accumulating evidence has shown that liver X receptor (LXR) is closely related to intrahepatic inflammation and fibrosis. In this study, we evaluated the effects novel liver-specific LXR inverse agonist, SR9243, on antifibrosis NASH mice. A high-cholesterol diet was employed induce BALB/c mice by either carbon tetrachloride (CCL4) administration or bile-duct ligation (BDL)....
Background: Left bundle branch area pacing (LBBAP) is a recently proposed method for conduction system pacing. We performed meta-analysis of controlled studies to compare the clinical outcome in patients who received LBBAP vs. biventricular (BVP) cardiac resynchronization therapy (CRT). Methods: PubMed, Embase, and Cochrane's Library databases were searched relevant studies. A random-effect model incorporating potential heterogeneity was used synthesize results. Results: Four non-randomized...
Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. However, little known about its pathogenicity in pangolins. Using CT scans we show that SARSr-CoV-2 positive pangolins are characterized by bilateral ground-glass opacities lungs a similar manner COVID-19 patients. Histological examination and blood gas tests indicative of dyspnea. infected multiple organs pangolins, with the major target, histological expression data revealed ACE2 TMPRSS2 were...