A5100409758- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- MicroRNA in disease regulation
- Natural Antidiabetic Agents Studies
- Ion channel regulation and function
- Bone health and treatments
- Bioactive natural compounds
- Adipose Tissue and Metabolism
- Chromatography in Natural Products
- Hepatitis B Virus Studies
- Dietary Effects on Health
- Ion Channels and Receptors
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Viral Infections and Vectors
- Asthma and respiratory diseases
- Parathyroid Disorders and Treatments
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
Capital Medical University
2016-2024
Beijing Chaoyang Emergency Medical Center
2024
Capital University
2023
University of Hong Kong
2022
China National Research Institute of Food and Fermentation
2021
Affiliated Hospital of Youjiang Medical University for Nationalities
2021
South Central Minzu University
2018-2020
Charlottesville Medical Research
2020
University of Mississippi Medical Center
2018-2019
Jilin University
2018-2019
Cancer cells are well-known to require a constant supply of protein, lipid, RNA, and DNA via altered metabolism for accelerated cell proliferation. Targeting metabolic pathways is, therefore, promising therapeutic strategy cancers. Oleanolic acid (OA) is widely distributed in dietary medicinal plants displays selective cytotoxicity cancer cells, primarily by inducing apoptosis cycle arrest. This study investigated if OA inhibited growth tumor affecting their metabolism. was found activate...
Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), regulates substrate metabolism in the heart. AMP-activated protein (AMPK) is age-related energy sensor that protects heart from ischemic injury. This study aims to investigate whether DCA can protect injury through AMPK signaling pathway. Young (3–4 months) and aged (20–24 male C57BL/6J mice were subjected ligation left anterior descending coronary artery (LAD) for vivo model. The systolic function hearts was...
The use of glucagon-like peptide-1 analogues, such as liraglutide, hypoglycemic drugs has been widely employed in clinical practice. Liraglutide is reported to exert potential anti‑breast cancer effects, however the specific mechanisms this action remain unknown. In present study, MCF‑7 human breast cells were cultured vitro and treated with various concentrations liraglutide. Cell Counting Kit‑8, colony formation flow cytometry assays performed determine proliferation apoptosis following...
Glucose transporter 4 (GLUT4) is involved in regulating glucose uptake striated muscle, liver and adipose tissue. Neferine a dibenzyl isoquinoline alkaloid derived from dietary lotus seeds has multiple pharmacological effects. Therefore, this study investigated neferine's role translocation to cell surface, GLUT4 expression. In our study, neferine upregulated expression, induced plasma membrane fusion, increased intracellular Ca2+, promoted alleviating insulin resistance L6 cells....
<h3>Background:</h3> It is uncertain whether metformin use associated with reduced risk of joint replacement in patients type 2 diabetes mellitus. We aimed to establish was a total knee (TKR) or hip (THR) among these patients. <h3>Methods:</h3> selected mellitus that diagnosed between 2000 and 2012 from the Taiwan National Health Insurance Research Database. used prescription time-distribution matching propensity-score balance potential confounders users nonusers. assessed risks TKR THR...
The number of patients with type 2 diabetes mellitus (T2DM) is increasing rapidly worldwide. Glucose transporter 4 (GLUT4) one the main proteins that transport blood glucose into cells and a target in treatment T2DM. In this study, we investigated mechanism action dandelion chloroform extract (DCE) on uptake L6 cells. consumption cell culture supernatant was measured by assay kit, dynamic changes intracellular GLUT4 calcium (Ca2+) levels were monitored laser scanning confocal microscopy...
In today's world, diabetes mellitus (DM) is on the rise, especially type 2 (T2DM), which characterized by insulin resistance. T2DM has high morbidity, and therapies with natural products have attracted much attention in recent past. this paper, we aimed to study hypoglycemic effect mechanism of an ethanolic extract Folium Sennae (FSE) L6 cells. The glucose uptake cells was investigated using a assay kit. We studied transporter 4 (GLUT4) expression AMP-activated protein kinase (AMPK), B...
<i>Aims:</i> We demonstrated a relationship between transforming growth factor-β<sub>1</sub> (TGF-β<sub>1</sub>) and production of bone matrix in vascular smooth muscle cells (VSMCs) induced by high-phosphate environment. <i>Methods:</i> Rat VSMCs were incubated (2.5 or 3.5 m<i>M</i>) TGF-β<sub>1</sub> (2 5 ng/ml) monoclonal neutralization antibody (50 µg/ml) was added to inhibit the signal medium. Production analyzed...
The Chinese herb
Abstract This work focused on the separation of active ingredients maca ( Lepidium meyenii Walpers) and evaluated antioxidative capability these components with effects improving glucose lipid metabolism in insulin‐resistant HepG2 cells. DPPH free radical scavenging reducing power assays were used to evaluate antioxidant activity extracts. An cell model induced by glucose, fructose, oleic acid, palmitic acid was adopted investigate extracts regulating this study. LC‐MS/MS then for...
As an activator of AMPK, the effect AICAR on insulin signaling has not been investigated extensively. PI3K-Akt is a critical node involved in pathway. We observed that concomitant with activation AMPK by AICAR, protein level PI3K p85α and insulin-induced phosphorylation Akt were enhanced mouse primary hepatocytes. Previously, we identified group AMPK-regulated miRNAs It clear whether are related to regulation AMPK. Here, confirmed negative miR-29 family members treatment Our results...
Abstract Background Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods EAED...
Abstract Interferon-α (IFN-α) induces the transfer of resistance to hepatitis B virus (HBV) from liver nonparenchymal cells (LNPCs) hepatocytes via exosomes. However, little is known about entry machinery and pathway involved in transmission IFN-α-induced antiviral activity. Here, we found that macrophage exosomes depend on T cell immunoglobulin mucin receptor 1 (TIM-1), a A (HAV) receptor, enter for delivering anti-HBV Moreover, two primary endocytic routes infection, clathrin-mediated...
Abstract Background Metformin has become the first-line therapy for type 2 diabetes mellitus (T2DM) and beneficial effects on cardiovascular disease (CVD). Remnant cholesterol (RC), of triglyceride-rich lipoproteins, is associated with risk CVD. Our research group first explored relationship between RC metabolic disorders in China. However, it still unclear whether metformin could decrease RC. This study aims to investigate effect monotherapy patients new-onset T2DM. Methods was nested an...
Insulin recruits muscle microvasculature which contributes to insulin’s metabolic action but is blunted in humans with obesity. Both exercise and glucagon-like peptide 1 (GLP-1) are potent enhancers of microvascular perfusion their actions preserved the insulin resistant states. To examine whether light GLP-1 receptor agonism modulate during development obesity, adult male rats were fed a high-fat diet (HFD) for 2 weeks either free access running wheel (light exercise), liraglutide (200...
Abstract Backgrond: Asthma is one of the intractable diseases recognized by world medical community. The current widely used bronchodilators β2-adrenal receptor agonists for asthma have limited therapeutic effects, which make it necessary to develop novel drugs with increased efficacy but fewer side-effects antiasthma treatments. In this study, we attempted investigate relaxing effects and mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle (ASM). Methods:...
Abstract Background: Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods: EAED...
Abstract Background: Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods: EAED...
Background: Whether metformin use is associated with reduced risks of total knee replacement (TKR) and/or hip (THR) in patients type 2 diabetes mellitus (DM) remains uncertain.Methods: We conducted a population-based cohort study using 2000-2013 Taiwan’s National Health Insurance Research Database. selected participants over 45 years old when they were newly diagnosed DM. Participants classified into users and non-users based on if was ever used after diagnosis. The index date (defined as...