A5069439667- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Dietary Effects on Health
- Fatty Acid Research and Health
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Fungal Plant Pathogen Control
- Advanced Drug Delivery Systems
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Neuropeptides and Animal Physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer therapeutics and mechanisms
- Birth, Development, and Health
- Phytochemistry and biological activities of Ficus species
- Cannabis and Cannabinoid Research
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- Drug Transport and Resistance Mechanisms
Beijing Chao-Yang Hospital
2023-2025
Capital Medical University
2023-2025
Capital University
2025
China Medical University
2023
China Pharmaceutical University
1998-2011
A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk. We developed an enzyme activity-screening platform to investigate microbiota-derived enzymes might influence physiology. discovered that dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa microbiota. Microbial DPP4 was able decrease active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Furthermore,...
Abstract Objectives The study aimed to explore the association between thyroid hormone (TH) sensitivity and obesity assessed by body mass index (BMI) visceral adiposity (VAI) in euthyroid adults. Methods This cross-sectional used Thyroid Feedback Quantile-based Index (TFQI), TSH (TSHI), thyrotrophic T4 resistance (TT4RI) indicate central TH sensitivity, VAI assess obesity. Participants were categorized according tertiles. We logistic linear regressions associations stratified sex. Results...
Abstract Background The relationship between thyroid hormone sensitivity and cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to investigate the association early-stage of CKM syndrome, with a specific focus on moderating effects sex age. Methods A total 8,391 euthyroid participants were enrolled in this cross-sectional study. Data metabolic parameters levels collected. Thyroid indices-thyroid feedback quantile index (TFQI), thyroid-stimulating (TSHI), TT4...
The relationship between non-alcoholic fatty liver disease (NAFLD) and thyroid function is controversial. A mild acquired hormone resistance may exist explain these contradictions. This study aims to investigate the associations of sensitivity with NAFLD severity fibrosis in euthyroid populations. Twenty-nine thousand three hundred eighty-six adult subjects were recruited from medical examination center Beijing Chao-Yang Hospital. Free triiodothyronine (FT3)/free thyroxine (FT4), feedback...
Abstract Aims Advanced cardiovascular-kidney-metabolic (CKM) syndrome has profound impacts on adverse clinical outcomes, particularly cardiovascular disease (CVD). Remnant cholesterol (RC) emerged as a potential risk factor for metabolic and disorders, but its association with CKM remains unexplored. This study aimed to investigate the relationship between RC progression. Methods utilized data from China Health Retirement Longitudinal Study (CHARLS) spanning 2011–2020. Logistic regression...
<title>Abstract</title> <bold>Background</bold>: For over half a century, dietary guidelines have consistently advocated for the substitution of saturated fatty acids (SFA) with monounsaturated (MUFA) and polyunsaturated (PUFA) as cornerstone strategy health life, but evidence on independent associations between specific mortality remains inconsistent. <bold>Methods</bold>: This prospective cohort study from National Health Nutrition Examination Survey (NHANES) 2007-2018 analyzed 21,823...
For over half a century, dietary guidelines have consistently advocated for the substitution of saturated fatty acids (SFA) with monounsaturated (MUFA) and polyunsaturated (PUFA) as cornerstone strategy health life, but evidence on independent associations between specific mortality remains inconsistent. This prospective cohort study from National Health Nutrition Examination Survey (NHANES) 2007-2018 analyzed 21,823 participants aged 20-80 years. Survey-weighted Cox regression assessed SFA,...
Hepatic encephalopathy (HE) is a central nervous system dysfunction syndrome caused by acute and chronic liver failure or various portal systemic shunt disorders. HE arises from metabolic disorder excludes other known types of encephalopathy. major cause death in people with disease. Early diagnosis timely treatment are key to improving prognosis. Herein, we established model performed metabolomics identify 50 significantly differential metabolites between the group control group. The main...
In this 2 × 2, randomized, crossover bioequivalence study, two tablet preparations of helicidum were compared in 20 healthy Chinese male subjects. The drug was given a single dose three tablets (75 mg) and blood samples withdrawn during 12 h after administration. Helicidum separated analyzed using validated liquid chromatography-mass spectrum method. pharmacokinetic parameters determined from the plasma concentration-time profiles both formulations. primary calculated statistically to...