A5102831579- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Ovarian function and disorders
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Effects of Environmental Stressors on Livestock
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Drug Transport and Resistance Mechanisms
- Photodynamic Therapy Research Studies
- Muscle Physiology and Disorders
- Dermatologic Treatments and Research
- S100 Proteins and Annexins
- Liver physiology and pathology
- Effects and risks of endocrine disrupting chemicals
- Liver Diseases and Immunity
- Pluripotent Stem Cells Research
- Kruppel-like factors research
- Muscle metabolism and nutrition
Peking University
2021-2025
Women's Hospital, School of Medicine, Zhejiang University
2023
Institute of Zoology
2014-2022
Chinese Academy of Sciences
2014-2022
University of Chinese Academy of Sciences
2015-2022
State Key Laboratory of Rare Earth Resources Utilization
2019-2022
Changchun Institute of Applied Chemistry
2018-2019
Guangzhou Medical University
2019
University of Science and Technology of China
2019
Shanghai Jiao Tong University
2015
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted from C57/BL6 mice into the dorsal subcutaneous region age- and sex-matched leptin deficient Ob/Ob Interestingly, led to significant reduction body weight gain with increased oxygen consumption...
Significance In the current study, we show that brown adipose tissue (BAT) activity is dramatically reduced in a dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat when compared with normal control rat. Importantly, key features of PCOS (such as insulin resistance and irregular estrous cycle) are alleviated after BAT transplantation. Mechanistically, transplanted enhances endogenous thereby increases circulating adiponectin level, which was lower both patient model....
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, natural compound extracted from mulberry drug used as capillary stabilizer clinically for many years without any side effects, regulated whole-body metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased expenditure, improved glucose homeostasis in both genetically obese (Db/Db) diet-induced...
A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk. We developed an enzyme activity-screening platform to investigate microbiota-derived enzymes might influence physiology. discovered that dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa microbiota. Microbial DPP4 was able decrease active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Furthermore,...
Significance Uncoupling protein 1 (UCP1) is responsible for brown adipose tissue-mediated thermogenesis and plays a critical role in protecting against cold regulating energy homeostasis. Modern pigs lack functional UCP1, which makes them susceptible to prone fat deposition results neonatal mortality decreased production efficiency. In the current study, CRISPR/Cas9-mediated homologous recombination-independent approach was established, mouse adiponectin-UCP1 efficiently inserted into...
Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold. Nevertheless, several pig breeds are known be cold resistant. The molecular mechanism(s) enabling such adaptation currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends UCP3 and white adipose tissue (WAT) browning. In two cold-resistant (Tibetan Min), a cold-sensitive breed (Bama), WAT browning was induced after exposure. Beige adipocytes from Tibetan pigs...
Ceramides play a central role in human health and disease, yet their as systemic signaling molecules remain poorly understood. In this work, we identify FPR2 membrane receptor that specifically binds long-chain ceramides (C14-C20). brown beige adipocytes, C16:0 ceramide binding to inhibits thermogenesis via G i -cyclic AMP pathways, an effect is reversed the absence of FPR2. We present three cryo–electron microscopy structures complex with trimers bound C16:0, C18:0 C20:0 ceramides. The...
Promoting development and function of brown beige fat may represent an attractive treatment obesity. In the current study, we show that Klf9 expression is markedly induced by cold exposure a β-adrenergic agonist. Moreover, levels in human white adipose tissue (WAT) are inversely correlated with adiposity, overexpression primary cells stimulates cellular thermogenesis, which Ucp1 dependent. Fat-specific transgenic mice gain less weight have smaller pads due to increased thermogenesis fat....
Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter-organ systems play key role in IF remains unclear. Here, novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss function studies and therapeutic experiment mice revealed that PZP promotes diet-induced thermogenesis activating brown adipose tissue (BAT)....
Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disease affecting women of reproductive age. Due to its complex aetiology, there no currently effective cure for PCOS. Brown adipose tissue (BAT) activity significantly decreased in PCOS patients, BAT activation has beneficial effects animal models Here, we investigated the effect ginsenoside compound K (CK) an model mechanism activation.Primary brown adipocytes, Db/Db mice dehydroepiandrosterone (DHEA)-induced rats were...
Hypertrophic scars are manifestations of an abnormal process tissue repair. Although photodynamic therapy is a promising treatment, details the mechanisms underlying its inhibitory effects remain to be elucidated.Fibroblasts were isolated from human hypertrophic scar specimens and subjected therapy; 5-aminolevulinic acid was used as photosensitizer. The accumulation acid-derived protoporphyrin IX detected under fluorescence microscopy. potential cytotoxicity alone with measured by...
Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance domestic animals, we sequenced genomes 28 cattle from warm and areas across China. By characterizing population structure demographic history, identified two genetic clusters, i.e., northern southern groups, well common historic peak at 30 kilo years ago. Genomic scan cold-tolerant breeds determined potential candidate genes thermogenesis-related...
PA treatment effectively and safely protected against obesity via the BAT-UCP1 axis. has therapeutic potential for treating type II diabetes.
Glioblastoma (GBM), the most common primary brain tumor, is aggressive malignancy in humans. Its rapid proliferation a major obstacle to successful treatment. Patients with GBM often suffer from psychological disturbances associated poor prognosis and physical discomfort. Diazepam one of frequently used benzodiazepines (BZs) cancer patients for its desirable psychotropic effects. The central effects BZs are mediated by activation BZ receptors. This study investigates whether diazepam has...
Brown adipose tissue (BAT), an organ that burns energy through uncoupling thermogenesis, is a promising therapeutic target for obesity. However, there are still no safe anti-obesity drugs BAT in the market. In current study, we performed large scale screening of 636 compounds which were approved by Food and Drug Administration (FDA) to find could significantly increase protein 1 (UCP1) mRNA expression real-time PCR. Among those UCP1 activators, most them antibiotics or carcinogenic...
The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account this. It demonstrated that erupting of pregnancy zone protein (PZP) from liver coincides with membrane translocation grp78 brown adipocytes during to activate (BAT), which partly explain metabolic benefits IFR. Liver-derived PZP appears be responsible all regulatory...
White adipose tissue (WAT) browning may have beneficial effects for treating metabolic syndrome. miRNA are important regulators of the differentiation, development, and function brown beige adipocytes. Here, we found that cold-inducible miRNA17-92 cluster is enriched in (BAT) compared with WAT. Overexpression miR17-92 C3H10T1/2 cells, a mouse mesenchymal stem cell line, enhanced thermogenic capacity Furthermore, observed significant reduction adiposity tissue-specific transgenic (TG) mice....