A5077201433- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Photoacoustic and Ultrasonic Imaging
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- MXene and MAX Phase Materials
- Luminescence Properties of Advanced Materials
- Laser Applications in Dentistry and Medicine
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced Photocatalysis Techniques
- Dental Erosion and Treatment
- Ga2O3 and related materials
- Extracellular vesicles in disease
- Conducting polymers and applications
- Silk-based biomaterials and applications
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Facial Trauma and Fracture Management
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Hubei University of Technology
2017-2021
Chinese Academy of Sciences
2019-2020
Jilin University
2019-2020
Changchun Institute of Applied Chemistry
2019-2020
Jilin Medical University
2019-2020
The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, it is hard to cure completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2 MoS4 (CMS) loaded with glucose oxidase (GOx) constructed for synergetic therapy by chemo-dynamic (CDT)/starvation therapy/phototherapy/immunotherapy. CMS harboring multivalent elements (Cu1+/2+ , Mo4+/6+ ) exhibit Fenton-like, glutathione (GSH) peroxidase-like catalase-like activity....
Abstract Rational design of tumor microenvironment (TME)‐activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are overexpressed endogenous H 2 S and slightly acidic microenvironment. Here, a core–shell Cu O@CaCO 3 nanostructure for CRC “turn‐on” therapy is reported. With CaCO pH decomposition O sulfuration, can be triggered “on” into therapeutic mode by TME. When shell decomposes releases...
Photoimmunotherapy can not only effectively ablate the primary tumor but also trigger strong antitumor immune responses against metastatic tumors by inducing immunogenic cell death. Herein, Cu2 MoS4 (CMS)/Au heterostructures are constructed depositing plasmonic Au nanoparticles onto CMS nanosheets, which exhibit enhanced absorption in near-infrared (NIR) region due to newly formed mid-gap state across Fermi level based on hybridization between 5d orbitals and S 3p orbitals, thus resulting...
There has been little application of fluorine-substituted hydroxyapatites (FHAs) in dental adhesives. Previous studies primarily focused on the effect fluoride content enamel remineralization, neglecting role FHA particle size. This study aimed to synthesize uniform nanorods varying sizes by adjusting fluorine doping levels, and investigate synergistic effects nanorod size remineralization incorporating into with levels were synthesized based a hydrothermal method. The characterization...
CeVO<sub>4</sub>/Ag nanohybrids can serve as photoconversion agents for solar-driven photocatalysis and PA/PT imaging-guided NIR-responsive photothermal/photodynamic therapy.
Strong and tough poly(vinyl alcohol) (PVA)/alginate hydrogen-bonded-ionic dual-physical double-network (DN) hydrogels have been successfully prepared by a facile route of freeze-thaw (25-25-25 °C) cycle followed concentrated (1.0 mol L-1 of) aqueous-Ca2+ immersion PVA/Na alginate (SA) mixed aqueous solutions. It was found that, at mole ratios the PVA- to SA repeat units 20/1 80/1, DN gels likely evolved semi-interpenetrating polymer network (IPN) morphology rigid networks dispersed in while...
We report a simple and facile self-assembly approach to fabricate polyelectrolyte complex (PEC) hydrogel films with positively charged chitosan (CS) negatively heparin sodium (HS) by combining hydrogen bonding electrostatic interactions. The CS/HS exhibited excellent tensile strength toughness, good self-recovery ability, superior water absorbency, pH-dependent surface charge characteristics. gelation mechanism was investigated zeta potential measurements. high antibacterial efficacy against...
The mechanical properties of thermosensitive hydrogels are significantly enhanced by DN structures. Antibacterial drugs can be readily loaded in the hydrogels, which response to external temperature change, release and deliver treatment on-site.
Luminescent net-like inorganic scaffolds with Eu<sup>3+</sup>-doped hydroxyapatite were firstly synthesized by the one-step hydrothermal method and thiol–ene click reaction.
Abstract Silicon (Si)‐based biomaterials are widely applied for bone regeneration. However, the underlying mechanisms of materials function remain largely unknown. T lymphocyte‐mediated adaptive immune response plays a vital role in process In current study, mesoporous silica (MS) is used as model material Si‐based biomaterials. It shows that supernatant CD4 + lymphocytes pretreated with MS extract significantly promotes vascularized The potential mechanism closely related to fact can reduce...
Effective bone tissue reconstitution improves the treatment success rate of dental implantation and preserves natural teeth during periodontal repair. Hydroxyapatite (HAp) has received much attention in remodeling field because its mineralized structure is similar to that tissue. For this reason, it been used as a carrier for growth factors. Although HAp possesses outstanding biomedical properties, capacity loading releasing factors promoting osteogenesis not well understood. In study, Ln3+...
Abstract Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and one most prevalent complex oral conditions. Oxidative stress induced by excessive generation reactive oxygen species (ROS) leads to periodontitis, which closely associated with pathological processes, including mitochondrial dysfunction periodontal cells local immune dysregulation. However, current treatment modalities that target single processes have limited long‐term therapeutic...
Polymer hydrogels are a type of soft and wet materials with three-dimensional network structure, large water content hydrophilicity. It plays very important effect in the human tissue engineering because it has some excellent characteristics as active tissue. In this study, physical/chemical hybrid cross-linked were prepared by "one-pot" method, mechanical properties effectively controlled immersing different concentration sodium chloride solution. The tensile strength can be increased from...
Although neodymium vanadate (NdVO4) has been investigated and applied in some fields owing to its intensive ultraviolet (UV) light absorption, weak absorption visible (Vis) near infrared (NIR) regions constrains environmental remediation biomedical applications. Herein, plasmonic precious metal Au as trapping agent is deposited onto NdVO4 form metal/semiconductor hybrid nanostructure for improving the Vis/NIR absorption. NdVO4/Au heterojunction nanocrystals (NCs) were synthesized by nanorods...