A5075990181- Heavy Metal Exposure and Toxicity
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Biosensors and Analytical Detection
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Insect and Pesticide Research
- Mycotoxins in Agriculture and Food
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Photonic and Optical Devices
- Neurogenesis and neuroplasticity mechanisms
- Remote-Sensing Image Classification
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Ubiquitin and proteasome pathways
- Flood Risk Assessment and Management
- Respiratory Support and Mechanisms
- Pesticide Exposure and Toxicity
- Transition Metal Oxide Nanomaterials
- Sirtuins and Resveratrol in Medicine
- Patient Satisfaction in Healthcare
Central South University
2010-2025
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shandong University
2023-2024
Innovation Team (China)
2021-2024
Zhengzhou University
2021-2024
Xi'an University of Technology
2024
Second Affiliated Hospital of Xinjiang Medical University
2023-2024
Xinjiang Medical University
2021-2024
Third Xiangya Hospital
2022-2023
// Wei Li 1, 2, * , Feng Gao 3, 4, Xiaoqian Ma Ruike Wang 5, Xin Dong 6 2 1 Department of Radiology, The Third Xiangya Hospital Central South University, Changsha, Hunan, 410000, P.R. China Cell Transplantation and Gene Therapy Institute, 3rd 3 Powder Metallurgy Research Institute 41000, 4 Ultrasonography, 5 School Medicine, P.R.China State Key Laboratory Molecular Oncology, Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, 100000, These authors contributed...
Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered promising antioxidant with respect to the prevention of deficits act as potent SIRT1 agonist. Herein, this study aims investigate profile neurogenesis markers following Pb exposure determine regulatory role resveratrol in process. We confirmed firstly protective effects against Pb-induced impairments hippocampal Male SD rats. caused altered expression...
This study examined the neuroprotective properties of resveratrol (Res) and its target sirtuin1 (SIRT1) against lead (Pb)-mediated toxicity discovered that both treatment SIRT1 overexpression restored blocked autophagic flux as well reduced β-amyloid (Aβ) contents. Four-week-old male C57BL/6 mice were employed to consumed 0.2% Pb(Ac)2 solution or deionized water for 3 months followed by 12 Res (50 mg/kg BW) vehicle gavage. In in vitro study, SH-SY5Y cells pretreated with activator SRT1720 (2...
Speckle projection profilometry (SPP) determines the global correspondence between stereo images by speckle pattern(s) in three-dimensional (3D) vision. However, it is extremely challenging for traditional algorithms to achieve a satisfactory 3D reconstruction accuracy generally via single-frame pattern, which heavily constraints application dynamic imaging. Recently some deep learning (DL) based methods have made process this issue but there exist deficiencies feature extraction, leading...
The widespread use of pesticides performs a vital role in safeguarding crop yields and quality, providing the opportunity for multiple to co-exist, which poses significant potential risk human health. To assess toxic effects caused by exposures individual (chlorpyrifos, carbofuran acetamiprid), binary combinations ternary combinations, combined exposure models were developed using HepG2 cells types pesticide mixtures assessed concentration addition (CA), independent action (IA) combination...
Hepatocellular carcinoma (HCC) resists immunotherapy due to its immunosuppressive microenvironment. Sarcoma homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) inhibits T cell receptor signaling, and pharmacological inhibition is limited by poor selectivity membrane permeability. Here, we generated CRISPR-edited SHP-1-knockout (KO) CD8+ cells enhance adoptive therapy against HCC. Single-cell RNA sequencing of HCC patient revealed elevated SHP-1 in exhausted subsets. SHP-1-KO...
Deregulation of epidermal growth factor receptor (EGFR) signaling is frequently observed in non-small cell lung cancer (NSCLC). The present study aimed to determine the impact dihydromyricetin (DHM) on NSCLC, a natural compound extracted from Ampelopsis grossedentata with various pharmacological activities. Results demonstrated that DHM may act as promising antitumor agent for NSCLC therapy, inhibiting cells vitro and vivo. Mechanistically, results exposure downregulated activity wild-type...
In patients undergoing off‑pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed observe cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, detect its potential protection against acute myocardial sensitive biomarkers. total, 36 OPCAB were randomly assigned into two groups, receiving (n=18) or as anesthetic agent. depth of anesthesia in groups was...
Ginkgo biloba extract EGb761 conveys an anticancer effect, but little is known regarding its role in hepatocellular carcinoma (HCC). Our study aims to determine the effect of on HCC cell lines and clarify underlying molecular mechanism. We explore biological functions using morphological observation, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cytotoxic analysis. investigate effects proliferation apoptosis cells plate clone formation, proliferating nuclear...