A5101412583- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
- Amyotrophic Lateral Sclerosis Research
- CRISPR and Genetic Engineering
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Heavy Metal Exposure and Toxicity
- Advanced Neuroimaging Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Functional Brain Connectivity Studies
- CAR-T cell therapy research
- Photosynthetic Processes and Mechanisms
- Paraoxonase enzyme and polymorphisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- RNA modifications and cancer
Second Hospital of Hebei Medical University
2016-2025
Fudan University
2023-2025
Zhongshan Hospital
2025
State Key Laboratory of Genetic Engineering
2025
Institute of Laboratory Animal Science
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Sichuan University
2007-2024
West China Hospital of Sichuan University
2024
Peking Union Medical College Hospital
2013-2023
Peking University
2023
Abstract Background Chinese bayberry ( Myrica rubra Sieb. and Zucc.) is an important subtropical fruit crop ideal species for quality research due to the rapid substantial changes that occur during development ripening, including in color taste. However, at molecular level limited by a lack of sequence data. The present study was designed obtain transcript data examine gene expression developing based on RNA-Seq bioinformatic analysis, provide foundation understanding mechanisms controlling...
Congenital absence of cone photoreceptor function is associated with strongly impaired daylight vision and loss color discrimination in human achromatopsia. Here, we introduce viral gene replacement therapy as a potential treatment for this disease the CNGA3−/− mouse model. We show that such can restore cone-specific visual processing central nervous system even if photoreceptors had been nonfunctional from birth. The restoration was assessed at different stages along pathway. Treated mice...
The mouse autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS), is primarily characterized as dysfunction the blood-brain barrier (BBB). Resveratrol exhibits anti-inflammatory, antioxidative, and neuroprotective activities. We investigated beneficial effects resveratrol in protecting integrity BBB EAE mice observed improved clinical outcome after treatment. Evans blue (EB) extravasation was used to detect disruption BBB. Western blot were detected tight...
The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. Clustered regularly interspaced short palindromic repeats ( CRISPR )/CRISPR‐associated 9 (Cas9) a simple efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of resources enable more studies gene function. To monitor Cre– loxP ‐mediated excision vivo , we generated Cre reporter strain Rosa26‐imCherry ) by knockin cassette at Rosa26 locus...
Experimental autoimmune encephalitis (EAE) is an inflammatory demyelinating disease, which served as a useful model providing considerable insights into the pathogenesis of multiple sclerosis (MS). Mouse bone marrow mesenchymal stem cells (mBM-MSC) were shown to have neuroprotection capabilities in EAE. Resveratrol small polyphenolic compound and possess therapeutic activity various immune-mediated diseases. The sensitivity mBM-MSCs resveratrol was determined by established cell-viability...
This study examined the neuroprotective properties of resveratrol (Res) and its target sirtuin1 (SIRT1) against lead (Pb)-mediated toxicity discovered that both treatment SIRT1 overexpression restored blocked autophagic flux as well reduced β-amyloid (Aβ) contents. Four-week-old male C57BL/6 mice were employed to consumed 0.2% Pb(Ac)2 solution or deionized water for 3 months followed by 12 Res (50 mg/kg BW) vehicle gavage. In in vitro study, SH-SY5Y cells pretreated with activator SRT1720 (2...
Abstract Previous studies of the Caveolin 1 (Cav1) protein and caveolae, which are lipid raft structures found on plasma membranes certain cells, associated with fat metabolism disorders, inflammation, diabetes, cardiovascular disease. However, there have been no reports linking Cav1 to diabetic cardiomyopathy (DCM). In present study, we established a relationship between development DCM. We that compared Cav1+/+ mice, Cav1−/− mice exhibited more severe cardiac injury, increased activation...
The time-related decline in regenerative capacity and organ homeostasis is a major feature of aging. Rehmannia glutinosa Astragalus membranaceus have been used as traditional Chinese herbal medicines for enhanced immunity prolonged life. However, the mechanism by which this medicine slows aging unknown. In study, we investigated anti-aging effect.Mice were fed diets supplemented with R. or A. 10 months; control group was standard diet. phenotypes evaluated using grading score system survival...
The triglyceride glucose (TyG) index, as a reliable marker of insulin resistance, is associated with the incidence and poor prognosis various cardiovascular diseases. However, relationship between TyG index clinical outcomes in patients severe aortic stenosis (AS) who underwent transcatheter valve replacement (TAVR) remains unclear. This study consecutively enrolled 1569 AS TAVR at West China Hospital Sichuan University April 2014 August 2023. interest included all-cause mortality, major...
Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS associated with serious cardiovascular remains the leading cause of mortality worldwide. Mesenchymal stem cells (MSCs) have evolved as an attractive therapeutic agent various diseases including AS. Human umbilical cord MSCs (UCSCs) been used cell therapy trials due to their ability differentiate proliferate. The present study aimed investigate effect UCSCs treatment on atherosclerotic plaque...
Natural killer (NK) cell-based immunotherapy shows promise in cancer treatment, but its efficacy remains limited, necessitating the development of novel strategies. In this study, we demonstrate that epigenetic factor BPTF (bromodomain PHD-finger containing transcription factor) hinders hepatocellular carcinoma (HCC) recognition by NK cells through PHD finger's interpretation H3K4me3. We have generated a small-molecule proteolysis-targeting chimera (PROTAC) selectively degrades human and...