A5012198733- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Virus-based gene therapy research
- Hepatitis C virus research
- RNA modifications and cancer
- Liver physiology and pathology
- Advanced biosensing and bioanalysis techniques
University of Science and Technology of China
2016-2025
Huzhou Vocational and Technical College
2025
Huzhou University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2003-2024
Changzhou No.2 People's Hospital
2024
Nanjing Medical University
2024
Shanghai University of Traditional Chinese Medicine
2024
Hefei National Center for Physical Sciences at Nanoscale
2014-2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2012-2023
Johns Hopkins Medicine
2021-2023
Significance In patients with coronavirus disease 2019, a large number of T lymphocytes and mononuclear macrophages are activated, producing cytokines such as interleukin-6 (IL-6), which bind to the IL-6 receptor on target cells, causing cytokine storm severe inflammatory responses in lungs other tissues organs. Tocilizumab, recombinant humanized anti-human monoclonal antibody, can high affinity, thus preventing itself from binding its receptor, rendering it incapable immune damage...
Liver natural killer (NK) cells were recently reported to possess memory-like properties in contact hypersensitivity (CHS) models. However, the phenotype and origin of these “memory” NK cannot be distinguished from other cell subpopulations. Here, we define transcriptional, phenotypic, functional features liver subsets their roles mediating CHS. can divided into two distinct subsets: CD49a+DX5– CD49a–DX5+. Substantial transcriptional phenotypic differences existed between subsets. possessed...
Influenza in humans is often accompanied by gastroenteritis-like symptoms such as diarrhea, but the underlying mechanism not yet understood. We explored occurrence of using a mouse model respiratory influenza infection. found that infection caused intestinal injury when lung occurred, which was due to direct viral altered microbiota composition, mediated IFN-γ produced lung-derived CCR9+CD4+ T cells recruited into small intestine. Th17 markedly increased intestine after PR8 infection, and...
Natural killer (NK) cells accumulate at the maternal–fetal interface in large numbers, but their exact roles successful pregnancy remain poorly defined. Here, we provide evidence that T H 17 and local inflammation can occur during natural allogenic pregnancies. We found decidual NK promote immune tolerance by dampening inflammatory via IFN-γ secreted CD56 bright CD27 + subset. This NK-cell–mediated regulatory response is lost patients who experience recurrent spontaneous abortions, which...
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East (MERS-CoV), cause high morbidity mortality 1,2 . Recently, a pneumonia-associated caused by new was reported at December 2019 (2019-nCoV) in the city Wuhan, Hubei province, China 3–5 , which also named (PARS) 6 Up to 9th of February 2020, least 37, 251 cases have been with 812 fatal according report from CDC. However, immune mechanism that potential orchestrated patients...
Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin ITIM domain (TIGIT), together with costimulatory CD226, bind common ligand CD155. The balancing between three receptors fine‐tunes responses against tumors. In this study, we investigated the expression of CD96, TIGIT, CD226 in 55 fresh human hepatocellular carcinoma (HCC) samples, 236 paraffin‐embedded HCC 20 normal livers. cumulative...
Background and Aims: As the predominant lymphocyte subset in liver, natural killer (NK) cells have been shown to be highly associated with outcomes of patients chronic hepatitis B virus infection (CHB) hepatocellular carcinoma (HCC). Previously, we reported that NKG2A, a checkpoint candidate, mediates human murine NK cell dysfunction CHB. However, exhaustion and, particularly, level NKG2A expression within liver tumors not reported.Methods: In this study, analyzed related located intra- or...
Abstract Several studies show that the immunosuppressive drugs targeting interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of immune cell composition two severe-stage prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation contributes cytokine storms. Furthermore, although tocilizumab treatment attenuates inflammation, cells,...
While the presence of airway bacteria is known to be associated with improved immunity against influenza virus, mechanism by which endogenous microbiota influence antiviral remains unclear. Here we show that specific pathogen-free mice are more sensitive influenza-mediated death than living in a natural environment. Priming Toll-like receptor 2-ligand+ Staphylococcus aureus, commonly colonizes upper respiratory mucosa, significantly attenuates lung immune injury. 2 deficiency or alveolar...
Abstract Natural killer (NK) cells exert critical roles in anti-tumor immunity but how their functions are regulated by epitranscriptional modification (e.g., N 6 -methyladenosine (m A) methylation) is unclear. Here we report decreased expression of the m A “writer” METTL3 tumor-infiltrating NK cells, and a positive correlation between protein levels effector molecules cells. Deletion Mettl3 alters homeostasis inhibits cell infiltration function tumor microenvironment, leading to accelerated...
Abstract Maintaining homeostasis of the decidual immune microenvironment at maternal–fetal interface is essential for placentation and reproductive success. Although distinct cell subpopulations have been identified under normal conditions, systematic understanding spectrum heterogeneity leukocytes recurrent miscarriage in human deciduas remains unclear. To address this, we profiled respective transcriptomes 18,646 primary cells isolated from patients with pregnancy loss (RPL) healthy...
Pregnancy disorders in patients with autoimmune diseases or viral infections are often associated an excessive response of type I interferons. We identify radical S-adenosyl methionine domain containing 2 (RSAD2) as a pathogenic interferon-stimulated gene (ISG) pregnancy complications systemic lupus erythematosus (SLE). The increased expression RSAD2 mainly occurs macrophages and structural cell populations at the maternal-fetal interface pregnant SLE. elevation leads to accumulation...
Summary The identification of developmental stages in natural killer (NK) cells, especially human NK has lagged for decades. We characterize four novel populations defined by CD11b and CD27, which can represent the distinct cells from different tissues. Nearly all peripheral blood are + CD27 − whereas cord have populations. Interestingly, we found large deciduas. also demonstrate that each population could be characterized unique functional phenotypic attributes. display an immature...