A5018414640- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Obstructive Sleep Apnea Research
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Tuberous Sclerosis Complex Research
- Sleep and Wakefulness Research
- Cancer-related gene regulation
- Congenital Diaphragmatic Hernia Studies
- Migraine and Headache Studies
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
Guangdong Academy of Medical Sciences
2025
Guangdong Provincial People's Hospital
2025
Central South University
2013-2024
Second Xiangya Hospital of Central South University
2012-2024
National Heart Centre Singapore
2024
Xuzhou Medical College
2024
Xuzhou No.1 People's Hospital
2024
China State Shipbuilding (China)
2024
University of Science and Technology of China
2003-2022
Hunan Provincial Center for Disease Control and Prevention
2020
Abstract Several studies show that the immunosuppressive drugs targeting interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of immune cell composition two severe-stage prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation contributes cytokine storms. Furthermore, although tocilizumab treatment attenuates inflammation, cells,...
Abstract Maintaining homeostasis of the decidual immune microenvironment at maternal–fetal interface is essential for placentation and reproductive success. Although distinct cell subpopulations have been identified under normal conditions, systematic understanding spectrum heterogeneity leukocytes recurrent miscarriage in human deciduas remains unclear. To address this, we profiled respective transcriptomes 18,646 primary cells isolated from patients with pregnancy loss (RPL) healthy...
The Notch signaling pathway plays critical role for determining cell fate by controlling proliferation, differentiation, and apoptosis. In the current study, we investigated roles of in cigarette smoke (CS)-induced endothelial apoptosis chronic obstructive pulmonary disease (COPD). We obtained surgical specimens from 10 patients with COPD control participants. Notch1, 2, 4 express cells, whereas Notch3 mainly localizes smooth muscle cells. Compared groups, found that expression 3, decreased,...
Abnormal apoptosis of lung endothelial cells has been observed in emphysematous tissue and suggested to be an important upstream event the pathogenesis chronic obstructive pulmonary disease (COPD). Studies have shown that microRNAs (miRNAs) contribute diseases by regulating cell apoptosis. The present study was designed investigate expression microRNA-34a (miR-34a) human microvascular (HPMECs) exposed cigarette smoke extract (CSE), potential regulatory role miR-34a apoptosis.Our results...
ABSTRACT Despite the current devastation of COVID-19 pandemic, several recent studies have suggested that immunosuppressive drug Tocilizumab can powerfully treating inflammatory responses occur in this disease. Here, by employing single-cell analysis immune cell composition severe-stage patients and these same post Tocilizumab-treatment remission, we identified a monocyte subpopulation specific to severe disease contributes storms patients. Although treatment attenuated strong response,...
Abstract Milk fat globule epidermal growth factor 8 (MFG-E8) participates in a range of cellular processes, including reducing apoptosis and oxidative stress. However, its protective activity against cigarette smoke-induced ferroptosis the pathogenesis chronic obstructive pulmonary disease (COPD) modulation MFG-E8 remain unclear. Here, we showed that smoke diminished protein levels but had no significant effect on mRNA lung tissues humans mice two human bronchial epithelial cell lines. could...
Abstract Background Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary (COPD). Our previous studies have validated Notch1 an anti-apoptotic signaling in CS-induced apoptosis. Resveratrol (RESV) is a naturally occurring polyphenol exhibits activity cells exposed many kinds of destructive stimulus. However, the effects resveratrol on not yet been fully elucidated. Therefore, aim this study...
Anaplastic lymphoma kinase (ALK) fusion events account for approximately 3-7% genetic alterations in non-small cell lung cancer (NSCLC) patients. In this study, we revealed the comprehensive genomic landscape of 44 ALK positive NSCLC patients using a 605-gene panel, and identified partners. The most common partner is EML4, forming variant 1 (v1, E13:A20, 18/44), 2 (v2, E20:A20, 5/44), 3 (v3, E6:A20, 13/44). Except novel gene detected new HMBOX1. At mutation level, TP53 frequently mutated...
T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of development thymocytes at genetic epigenetic levels. However, double-positive (DP) cells, which comprise majority thymocytes, has not been well investigated.
Objectives: This work aims to explore the changes of functional connectivity (FC) within hippocampus network in patients with moderate and severe obstructive sleep apnea (OSA) its correlation neurocognitive dysfunction potential neurophysiological mechanism. Methods: A total 32 treatment-naïve or OSA 26 healthy controls (HCs), matched age, gender, education, underwent evaluations Epworth Sleep Scale, function, full-night polysomnography, resting-state magnetic resonance imaging. The FC map...
ABSTRACT As global aging accelerates, the incidence of thyroid diseases, particularly hypothyroidism, is rising in elderly. The thyroid‐stimulating hormone (TSH) levels increase healthy elderly populations. However, whether undergoes cellular senescence and how this relates to (TH) synthesis remain unclear. To investigate molecular functional characteristics aging, we performed scRNA‐seq on human thyroids from young, middle‐aged, old groups, identifying thousands aging‐related differentially...
Migraine is a debilitating neurological condition, with global prevalence rate of 10.68% in men and 18.79% women. Elucidation the molecular mechanisms underlying migraines great importance for improving quality life patients. The release neuropeptide calcitonin gene‐related peptide (CGRP) from trigeminal nerve terminals involved pathogenesis migraine. Recent studies have shown that up‐regulation miR‐34a‐5p expression associated acute migraine attacks. Here, we investigated whether alteration...
Smoking causes lung endothelial cell apoptosis and emphysema. Derived from bone marrow, circulating progenitor cells (EPCs) maintain vascular integrity by replacing repairing damaged cells. influences the number of EPCs. Recruitment EPCs marrow to peripheral blood depends on interaction c-Kit/soluble c-Kit ligand (sKitL). We hypothesized that smoking might influence c-Kit(+) EPCs/sKitL in development smoking-related In this study, we used a cigarette smoke extract (CSE)-induced emphysema...