A5101727266- Chronic Obstructive Pulmonary Disease (COPD) Research
- High Altitude and Hypoxia
- Reproductive biology and impacts on aquatic species
- Animal Genetics and Reproduction
- Marine Biology and Environmental Chemistry
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Travel-related health issues
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Cancer-related gene regulation
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Nutritional Studies and Diet
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Central South University
2014-2025
Third Xiangya Hospital
2019-2025
Second Xiangya Hospital of Central South University
2014-2025
First Hospital of China Medical University
2016-2025
China Medical University
2015-2025
Yangtze University
2025
Xizang Minzu University
2015-2024
Second Affiliated Hospital of Nanjing Medical University
2017-2024
Jilin University
2024
Xi'an Jiaotong University
2023
Significant changes in body composition are known to occur with aging. The aim of the present study was provide a normative reference and investigate age sex-related differences healthy subjects by multifrequency bioelectrical impedance analyzer (BIA). A cross-sectional conducted on sample 3451 Chinese adults, 1611 males 1840 females. volunteers were enrolled 5 different bands (18–30, 31–40, 41–50, 51–60, 60+). All measured for weight height submitted BIA, determine composition. Body...
1. Intracellular membrane potential recordings were made from circular smooth muscle cells of the guinea-pig ileum in presence atropine (1 microM) and nifedipine (0.1 at 30 degrees C. 2. Perfusion with adenosine triphospate (ATP, 100 vasoactive intestinal peptide (VIP, 2 resulted hyperpolarizations 6.4 +/- 0.3 6.8 mV, respectively. Picospritzes ATP (10 mM pipette) VIP (100 microM 6.9 0.4 6.3 3. The ATP-induced antagonized by alpha, beta-methylene desensitization for min) antagonist Reactive...
Steroidogenic factor-1 (Sf-1) (officially designated nuclear receptor subfamily 5 group A member 1 [NR5A1]) is a master regulator of steroidogenesis and reproduction in mammals. However, its function remains unclear nonmammalian vertebrates. In the present study, we used immunohistochemistry to detect expression Sf-1 steroidogenic cells, interstitial, granulosa, theca cells ovary, Leydig testis, Nile tilapia. Clustered regularly interspaced short palindromic repeats/CRISPR associated protein...
Objective: Autoimmune thyroid disease is an organ-specific disorder due to the interplay between environmental and genetic factors. Toll-like receptors are pattern recognition expressed abundantly on monocytes. There a paucity of data TLR expression in autoimmune (AITD). The aim this study was examine expression, activation, ligands, downstream signaling adaptors PBMCs extracted from untreated patients healthy controls. Method: We isolated peripheral blood mononuclear cells (PBMC) 30...
Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality currently. Long-term exposure cigarette smoke (CS) inducing persistent inflammation, small airway remodeling emphysematous lung are the distinguishing features COPD. Ferroptosis, occurred in epithelial cells has recently been reported to be associated with COPD pathogenesis. DNA dioxygenase ten-eleven translocation 2 (TET2) an important demethylase its genetic mutation low forced expiratory...
Mice lacking neuronal nitric oxide synthase gene (ncNOS) were used to determine the enzymatic source of (NO) and its relationship with other putative inhibitory neurotransmitters. Inhibitory junction potentials (IJP) circular smooth muscle gastric fundus studied. The IJP in wild-type mice consists overlapping components, fast slow IJPs. NOS inhibitor L-NA or VIP receptor antagonist VIP(10-28), blocks but not IJP. UP is blocked by alpha-beta methylene ATP tachyphylaxis, reactive blue 2,...
Abstract Milk fat globule epidermal growth factor 8 (MFG-E8) participates in a range of cellular processes, including reducing apoptosis and oxidative stress. However, its protective activity against cigarette smoke-induced ferroptosis the pathogenesis chronic obstructive pulmonary disease (COPD) modulation MFG-E8 remain unclear. Here, we showed that smoke diminished protein levels but had no significant effect on mRNA lung tissues humans mice two human bronchial epithelial cell lines. could...
High mobility group box-1 (HMGB1), a non-histone protein, plays an important role in autoimmune diseases. However, the significance of HMGB1 pathogenesis thyroiditis has not been reported. The purpose this study was to explore whether participates thyroiditis, and glycyrrhizin (GL), direct inhibitor HMGB1, attenuates severity thyroid inflammatory infiltration murine model thyroiditis.A total 80 male NOD.H-2h4 mice were randomly divided into control or iodine supplement (NaI) at four weeks...
Multidrug resistance (MDR), mainly mediated by ABCB1 transporter, is a major cause for chemotherapy failure. Bufalin (BU), an active component of the traditional Chinese medicine chan'su, has been reported to have antitumor effects on various types cancer cells. The purpose this present study was investigate reversal effect BU ABCB1-mediated multidrug in colorectal cancer. at safe concentration (5, 10, 20 nM) could reverse chemosensitivity ABCB1-overexpression HCT8/ADR, LoVo/ADR and...
Multidrug resistance (MDR) is the major reason for failure of chemotherapy in colon cancer. Bufalin (BU) one most effective antitumor active constituents Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR However, clinical application limited due to its low solubility water and high toxicity. In present study, a multifunctional delivery system based on vitamin-E- succinate grafted chitosan oligosaccharide (VES-CSO) cyclic...
Abstract Background Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis emphysema. However, an attempt accurately identify whether these interact with each other how they are triggered has never been conducted. Method The total reactive oxygen species (ROS) level, B-cell lymphoma/leukemia-2 (Bcl-2) expression, regulator, were detected in samples from COPD...
An inwardly rectifying K + conductance closely resembling the human ether-a-go-go-related gene (HERG) current was identified in single smooth muscle cells of opossum esophageal circular muscle. When were voltage clamped at 0 mV, isotonic solution (140 mM), step hyperpolarizations to −120 mV 10-mV increments resulted large inward currents that activated rapidly and then declined slowly (inactivated) during test pulse a time- voltage- dependent fashion. The HERG channel blockers E-4031 (1 μM),...
Purpose: Epigenetic modification is one of most important mechanisms underlying the pathogenesis chronic obstructive pulmonary disease (COPD).The purpose this study was to determine whether histone acetyltransferase binding ORC1 (HBO1) can protect against cigarette smoke (CS)-induced cell apoptosis and sustain normal acetylation in COPD.Methods: Human lung tissue samples were obtained from patients who underwent resection.The emphysema mouse model HBO1 overexpressing mice each established by...
Guidelines specify steroids as therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the duration survival benefit associated with and optimal dosage nebulized budesonide (NB) during hospitalization remain unclear. We conducted a retrospective study hospitalized AECOPD patients. The primary endpoint was all-cause mortality after discharge. Cox regression analysis used to determine impact steroid on survival. Wilcoxon showed positive systemic...
To evaluate the potential dose-response relationships of all-cause and cardiovascular death with accumulation various dietary habits. A prospective cohort study. Twenty-three habits were assessed through face-to-face interviews 57,737 participants in health check-up programs from 2015 to 2021. The total score was calculated as sum each habit multiplied by its own full-adjusted coefficient (β) for mortality Cox proportional hazard models. models fitted associations cause-specific scores 1,692...
Fibroblast growth factor 9 (FGF9) is a crucial regulator of hair follicle development; however, the precise regulatory role FGF9 on biological behavior follicles remains unclear. Explore effects recombinant human fibroblast (rhFGF9) and cycle transition in mice, as well associated mechanisms. We utilized soluble (rhFGF9), expressed Escherichia coli, injected it into dorsal skin mice. RNA sequencing (RNA-seq) was employed to identify differentially genes key metabolic pathways tissue....
<title>Abstract</title> Background To analyze the poor mental status of patients with primary closed-angle glaucoma(PACG), and to explore correlation between ocular systemic indices in PACG. Methods We collected patients' axial length (AL), anterior chamber depth (ACD), nerve fiber layer thickness (RNFL), cup-to-disc ratio (C/D), antinuclear antibody (ANA), toxoplasmosis (anti-Toxoplasma gondii IgM), anxiety depression scores (HAMA HAMD scales). Statistical analysis was utilized data for...