A5101894451- Cancer Genomics and Diagnostics
- Plant Stress Responses and Tolerance
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Food composition and properties
- Plant responses to water stress
- Crop Yield and Soil Fertility
- Circular RNAs in diseases
- Virus-based gene therapy research
- Animal Virus Infections Studies
- CRISPR and Genetic Engineering
- Phytase and its Applications
- SARS-CoV-2 and COVID-19 Research
- Wheat and Barley Genetics and Pathology
- RNA Interference and Gene Delivery
- Plant responses to elevated CO2
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Hair Growth and Disorders
- Epigenetics and DNA Methylation
- Chemotherapy-related skin toxicity
- Polysaccharides Composition and Applications
- Evolution and Genetic Dynamics
Beijing Forestry University
2025
State Key Laboratory of Tree Genetics and Breeding
2025
Nanjing Agricultural University
2016-2024
Jiangxi Normal University
2024
University of Science and Technology of China
2012-2024
Fujian Medical University
2024
Nanfang Hospital
2022-2024
State Forestry and Grassland Administration
2024
International Bamboo and Rattan Organization
2024
ShanghaiTech University
2024
In recent decades, with the continuous development of high-throughput sequencing technology, data volume in medical research has increased, at same time, almost all clinical researchers have their own independent omics data, which provided a better condition for mining and deeper understanding gene functions. However, these large amounts many common cutting-edge effective bioinformatics methods still cannot be widely used. This encouraged establishment analytical platforms, portion databases...
MicroRNAs are involved in various critical functions, including the regulation of cellular differentiation, proliferation, angiogenesis, and apoptosis. We hypothesize that microRNA-210 can rescue cardiac function after myocardial infarction by upregulation angiogenesis inhibition apoptosis heart.Using microRNA microarrays, we first showed was highly expressed live mouse HL-1 cardiomyocytes compared with apoptotic cells 48 hours hypoxia exposure. confirmed polymerase chain reaction robustly...
Background and Aims: As the predominant lymphocyte subset in liver, natural killer (NK) cells have been shown to be highly associated with outcomes of patients chronic hepatitis B virus infection (CHB) hepatocellular carcinoma (HCC). Previously, we reported that NKG2A, a checkpoint candidate, mediates human murine NK cell dysfunction CHB. However, exhaustion and, particularly, level NKG2A expression within liver tumors not reported.Methods: In this study, analyzed related located intra- or...
Despite the promise shown by stem cells for restoration of cardiac function after myocardial infarction, poor survival transplanted has been a major issue. Hypoxia-inducible factor-1 (HIF1) is transcription factor that mediates adaptive responses to ischemia. Here, we hypothesize codelivery progenitor (CPCs) with nonviral minicircle plasmid carrying HIF1 (MC-HIF1) into ischemic myocardium can improve CPCs.After CPCs were codelivered intramyocardially adult NOD/SCID mice saline, MC-green...
AIMTo determine whether circular RNAs (circRNAs) are involved in pathological processes of gastric cancer (GC). METHODSThree circRNAs with differential expression GC and colorectal were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), using 20 pairs tissues normal tissues.Based on the predicted circRNA-miRNA network, we then focused hsa_circ_0000745, which was found to be down-regulated compared tissues.The hsa_circ_0000745
Drought stress is a limiting factor for wheat production and food security. priming has been shown to increase drought tolerance in wheat. However, the underlying mechanisms are unknown. In present study, genes encoding biosynthesis metabolism of abscisic acid (ABA) jasmonic (JA), as well involved ABA JA signaling pathways were up-regulated by priming. Endogenous concentrations increased following The interplay between plant responses was further investigated using inhibitors biosynthesis....
Human embryonic stem (hES) cells are pluripotent capable of self-renewal and differentiation into virtually all cell types. Thus, they hold tremendous potential as sources for regenerative therapies. The concurrent development accurate, sensitive, noninvasive technologies monitoring hES engraftment in vivo can greatly expedite basic research prior to future clinical translation. In this study, were stably transduced with a lentiviral vector carrying novel double-fusion reporter gene that...
Background— Although stem cell therapy has provided a promising treatment for myocardial infarction, the low survival of transplanted cells in infarcted myocardium is possibly primary reason failure long-term improvement. Therefore, development novel prosurvival strategies to boost will be significant benefit this field. Methods and Results— Cardiac progenitor (CPCs) were isolated from transgenic mice, which constitutively express firefly luciferase green fluorescent protein. The CPCs...
Induction of the unfolded protein response (UPR) is an adaptive cellular to endoplasmic reticulum (ER) stress that allows a cell reestablish ER homeostasis. However, under severe and persistent stress, prolonged UPR may activate unique pathways lead death. In this study, we investigated activation kinase R-like (PERK) pathway in cells infected with coronavirus infectious bronchitis virus (IBV) its relationship IBV-induced apoptosis. The results showed moderate induction PERK phosphorylation...
Lipid raft is an important element for the cellular entry of some viruses, including coronavirus infectious bronchitis virus (IBV). However, exact role lipid rafts in membrane during IBV into host cells still unknown. In this study, we biochemically fractionated IBV-infected via sucrose density gradient centrifugation after depleting plasma cholesterol with methyl-β-cyclodextrin or Mevastatin. Our results demonstrated that unlike non-structural proteins, structural proteins co-localized...
Abstract A chronic viral or tumor microenvironment can push T cells to exhaustion by promoting coinhibitory ligand expression. However, how host factors control expression and whether infection breaks this during progress is unknown. Here we show a close negative correlation between SALL4 PD-L1 miR-200c in tumors from 98 patients with HBV-related hepatocellular carcinoma. correlates negatively expression, lower levels of higher survive longer. Moreover, over-expression antagonizes...
Salicylic acid (SA) can induce plant resistance to biotic and abiotic stresses through cross talk with other signaling molecules, whereas the interaction between hydrogen peroxide (H2O2) abscisic (ABA)in response SA signal is far from clear. Here, we focused on roles interactions of H2O2 ABA in SA-induced freezing tolerance wheat plants. Exogenous pretreatment significantly induced via maintaining relatively higher dark-adapted maximum photosystem II quantum yield, electron transport rates,...
Gemcitabine resistance is currently the main problem of chemotherapy for advanced pancreatic cancer patients. The thought to be caused by altered drug metabolism or reduced apoptosis cells. However, underlying mechanism in remains unclear. In this study, we established resistant PANC-1 (PANC-1-GR) cell lines and compared circular RNAs (circRNAs) profiles between cells PANC-1-GR RNA sequencing. Differentially expressed circRNAs were demonstrated using scatter plot cluster heatmap analysis....
Abstract The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view NK and provides another opportunity to study cells. Although evidence has suggested roles for liver diseases, whether how contribute diseases remain unclear. In this study, we observed that accumulation tissue-resident human hepatocellular carcinoma (HCC) was higher than peritumoral tissues. We studied the exhausted regulatory phenotypes by analysis protein mRNA. proportion positively correlated...
Abstract Floral thermogenesis is an ancient feature that facilitates mutualism between flowers and pollinators. Yet localization of specific thermogenic tissues within floral organs has received little attention. Here, we integrated infrared (IR) thermal imaging micro X-ray fluorescence (μ-XRF) to localize the in lotus (Nelumbo nucifera Gaertn.) receptacle. IR preliminarily identified primary receptacle as carpels epidermis. The calcium distribution visualized by μ-XRF complemented results...
Differentiation of human embryonic stem cells into endothelial (hESC-ECs) has the potential to provide an unlimited source for novel transplantation therapies ischemic diseases by supporting angiogenesis and vasculogenesis. However, differentiation efficiency conventional embryoid body (EB) method is low while 2-dimensional co-culturing with mouse fibroblasts (MEFs) require animal product, both which can limit future clinical application hESC-ECs. Moreover, fully understand beneficial...