A5018164245- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- NF-κB Signaling Pathways
- Immune cells in cancer
- Cell death mechanisms and regulation
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactivity Studies
- Phagocytosis and Immune Regulation
- Biological and pharmacological studies of plants
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Hops Chemistry and Applications
- Advanced X-ray and CT Imaging
- Toxin Mechanisms and Immunotoxins
- Medicinal plant effects and applications
- PI3K/AKT/mTOR signaling in cancer
- Plant-based Medicinal Research
- Inflammatory mediators and NSAID effects
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
Central South University
2022-2025
Third Xiangya Hospital
2022-2024
Second Xiangya Hospital of Central South University
2024
Sichuan University
2024
Tumor growth processes result in spatial heterogeneity, with the development of tumor subregions (i.e., habitats) having unique biologic characteristics.
Aerobic glycolysis, a typical phenotype in human tumors, is associated with tumor progression and chemotherapy resistance. The present study demonstrated that cisplatin-resistant oral squamous cell carcinoma (OSCC) cells exerted stronger glycolysis ability, which was hexokinase 2 (HK2) overexpression. Additionally, the growth of OSCC delayed vivo notably decreased following HK2 knockdown. natural compound screening revealed gastrodin could be an effective candidate for therapy since it...
Abstract The E3 ligase TNF receptor-associated factor 4 (TRAF4) is upregulated and closely associated with tumorigenesis the progression of multiple human malignancies. However, its effect on radiosensitivity in colorectal cancer (CRC) has not been elucidated. present study found that TRAF4 was significantly increased CRC clinical tumor samples. Depletion impaired malignant phenotype cells sensitized irradiation-induced cell death. Irradiation activated c-Jun N-terminal kinases (JNKs)/c-Jun...
Abstract The E3 ligase TNF receptor-associated factor 4 (TRAF4) is frequently overexpressed and closely related to poor prognosis in human malignancies. However, its effect on carcinogenesis radiosensitivity oral squamous cell carcinoma (OSCC) remains unclear. present study found that TRAF4 was significantly upregulated primary relapsed OSCC tumor tissues. Depletion of markedly improved the sensitivity cells irradiation (IR) treatment, showing proliferation, colony formation xenograft growth...
Deregulation of epidermal growth factor receptor (EGFR) signaling is frequently observed in non-small cell lung cancer (NSCLC). The present study aimed to determine the impact dihydromyricetin (DHM) on NSCLC, a natural compound extracted from Ampelopsis grossedentata with various pharmacological activities. Results demonstrated that DHM may act as promising antitumor agent for NSCLC therapy, inhibiting cells vitro and vivo. Mechanistically, results exposure downregulated activity wild-type...
Ovarian cancer is a common, highly lethal tumor. Herein, we reported that S-phase kinase-associated protein 2 (Skp2) essential for the growth and aerobic glycolysis of ovarian cells. Skp2 was upregulated in tissues associated with poor clinical outcomes. Using customized natural product library screening, found xanthohumol inhibited cell viability Xanthohumol facilitated interaction between E3 ligase Cdh1 promoted Ub-K48-linked polyubiquitination degradation. depletion reversed...
Dysfunctional tumor vasculature, hypoxia, and an immunosuppressive microenvironment are significant barriers to effective cancer therapy. Autophagy, which is critical for maintaining cellular homeostasis apoptosis resistance, primarily triggered by hypoxia nutrient deprivation, conditions prevalent in dysfunctional vessels due poor circulation. However, the role of autophagy endothelial cells its impact on treatment (TME) remain poorly understood. Methods: We used multiplex...