A5080866748- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Air Quality and Health Impacts
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
- Exercise and Physiological Responses
- Hepatitis B Virus Studies
- Ion Transport and Channel Regulation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phytoestrogen effects and research
- Sirtuins and Resveratrol in Medicine
- Hormonal Regulation and Hypertension
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Chromatography in Natural Products
- Diet and metabolism studies
- Hepatitis C virus research
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
Cheongju University
2015-2024
Sejong University
2004-2015
Ajou University
2006-2009
Czech Academy of Sciences, Institute of Biotechnology
2003
The number and morphology of mitochondria within a cell are precisely regulated by the mitochondrial fission fusion machinery. human protein, hFis1, participates in recruiting Drp1 into mitochondria. Using short hairpin RNA, we reduced expression levels hFis1 mammalian cells. Cells lacking showed sustained elongation underwent significant cellular morphological changes, including enlargement, flattening, increased granularity. In these cells, staining for acidic senescence-associated...
The COX-2/PGE2 pathway in hypoxic cancer cells has important implications for stimulation of inflammation and tumourigenesis. However, the mechanism by which glucocorticoid receptors (GRs) inhibit COX-2 during hypoxia not been elucidated. Hence, we explored mechanisms underlying glucocorticoid-mediated inhibition hypoxia-induced human distal lung epithelial A549 cells.The expressions glucocorticoid-induced leucine zipper (GILZ) were determined Western blot and/or quantitative real time-PCR...
Objectives In deoxycorticosterone acetate (DOCA)-salt hypertensive rats, altered reactivity of blood vessels to vasoactive agonists is frequently associated with an elevation in pressure. Canonical transient receptor potential (TRPC) channels are believed encode receptor-operated cation (ROC), the activation which involved smooth muscle depolarization and vasoconstriction. The aims present study were investigate whether ROC current increased DOCA-hypertensive rats determine aldosterone...
The mitochondrial antiviral signaling (MAVS) protein on the outer membrane acts as a central molecule in RIG-I-like receptor (RLR) pathway by linking upstream viral RNA recognition to downstream signal activation. We previously reported that E3 ubiquitin ligase, MARCH5, degrades MAVS aggregate and prevents persistent signaling. Since activated RIG-I oligomer interacts nucleates aggregate, MARCH5 might also target this oligomer. Here, we report targets RIG-I, but not its inactive...
Regular exercise provides several health benefits that can improve the cardiovascular and musculoskeletal systems, but clear evidence on effect of exercise-induced hyperventilation in particulate matter (PM) exposure is still lacking. This study aimed to investigate effects PM reactive oxygen species (ROS) generation, inflammatory response, mitochondrial integrity human lung epithelial cells (A549), as well mouse tissue. In vitro experiments, treatment was shown significantly increased ROS...
Abstract Introduction Estrogen receptor (ER) β is predicted to play an important role in prevention of breast cancer development and metastasis. We have shown previously that ERβ inhibits hypoxia inducible factor (HIF)-1α mediated transcription, but the mechanism by which works exert this effect not understood. Methods Vascular endothelial growth (VEGF) was measured conditioned medium enzyme-linked immunosorbent assays. Reverse transcription polymerase chain reaction (RT-PCR), Western...
Abstract Cells are constantly challenged by genotoxic stresses that can lead to genome instability. The integrity of the nuclear is preserved DNA damage response (DDR) and repair. Additionally, these induce mitochondria transiently hyperfuse; however, it remains unclear whether canonical DDR linked mitochondrial morphological changes. Here, we report abolition fusion causes a substantial defect in ATM-mediated signaling. This deficiency overcome restoration fusion. In cells with fragmented...
Previously, we showed that hypoxia induces ligand‐independent estrogen receptor (ER)α activation. In this study, found activated the ERβ‐mediated transcriptional response in HEK293 cells absence of estrogen. ERβ transactivation was induced by expression hypoxia‐inducible factor 1α (HIF‐1α) under normoxia. interacted with HIF‐1α, and SRC1 CBP potentiated effect HIF‐1α on transcription. We then examined HIF1‐α transactivation. Surprisingly, attenuated activity as measured HRE‐driven reporter...
Hepatitis B virus X protein (HBx) plays a role in liver cancer development. We previously showed that ROS increased HBx levels and here, we investigated the of antioxidants regulation expression their clinical relevance. found overexpression catalase induced significant loss levels. The cysteine null mutant (Cys-) dramatic reduction its stability. In clonogenic proliferation assays, Huh7-X cells produced number colonies whereas Huh7-Cys- failed to generate them. Cys at position 69 was...
Inhalation of ambient particulate matter (PM) can disrupt the gut microbiome, while exercise independently influences microbiome by promoting beneficial bacteria. In this study, we analyzed changes in microbial diversity and composition response to combined interventions PM exposure aerobic exercise, extending up 12 weeks. This investigation was conducted using mice, categorized into five groups: control group (Con), (EXE), followed 3-day (EXE + PM), (PM), with concurrent treadmill (PME)....
SummaryAvenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the cytokine levels. This study investigated effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression A549 cells. suppressed increase COX-2 protein levels and promoter activity. We also observed that were reversed a SIRT1 inhibitor, indicating inhibitory are mediated SIRT1. Therefore, inhibits hypoxic induction via activation. Our results suggest could be beneficial for...