A5027886490- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Computational Drug Discovery Methods
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Pancreatic function and diabetes
- Cancer Genomics and Diagnostics
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Machine Learning in Bioinformatics
- CRISPR and Genetic Engineering
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Gene Regulatory Network Analysis
- Aortic aneurysm repair treatments
- Genomics and Chromatin Dynamics
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
Peking University
2016-2025
Wuhan Sports University
2023-2025
Binzhou People's Hospital
2025
Yunnan University
2012-2024
Nanfang Hospital
2024
Shandong University of Traditional Chinese Medicine
2018-2024
Shandong Academy of Chinese Medicine
2020-2024
Peking University Third Hospital
2017-2024
Southern Medical University
2024
King University
2021-2022
Recently, the potential role of gut microbiome in metabolic diseases has been revealed, especially cardiovascular diseases. Hypertension is one most prevalent worldwide, yet whether microbiota dysbiosis participates development hypertension remains largely unknown. To investigate this issue, we carried out comprehensive metagenomic and metabolomic analyses a cohort 41 healthy controls, 56 subjects with pre-hypertension, 99 individuals primary hypertension, performed fecal transplantation...
The Human microRNA Disease Database (HMDD; available via the Web site at http://cmbi.bjmu.edu.cn/hmdd and http://202.38.126.151/hmdd/tools/hmdd2.html) is a collection of experimentally supported human (miRNA) disease associations. Here, we describe HMDD v2.0 update that presented several novel options for users to facilitate exploration data in database. In updated database, miRNA–disease association were annotated more details. For example, from genetics, epigenetics, circulating miRNAs...
In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. recent years, large number of lncRNAs have been identified increasing evidence shows that play critical roles in various biological processes. Therefore, the dysfunctions are associated with wide range diseases. It thus becomes important to understand lncRNAs’ diseases identify candidate for diagnosis, treatment...
It has been reported that increasingly microRNAs are associated with diseases. However, the patterns among microRNA-disease associations remain largely unclear. In this study, in order to dissect of associations, we performed a comprehensive analysis human association data, which is manually collected from publications. We built microRNA disease network. Interestingly, tend show similar or different dysfunctional evidences for clusters, respectively. A negative correlation between...
Abstract Motivation: It is popular to explore meaningful molecular targets and infer new functions of genes through gene functional similarity measuring network construction. However, little work available in this field for microRNA (miRNA) due limited miRNA annotations. With the rapid accumulation miRNAs, it increasingly needed uncover their relationships a systems level. Results: known that with similar are often associated diseases, relationship different diseases can be represented by...
N6-methyladenosine (m6A) is a prevalent RNA methylation modification involved in the regulation of degradation, subcellular localization, splicing and local conformation changes transcripts. High-throughput experiments have demonstrated that only small fraction m6A consensus motifs mammalian transcriptomes are modified. Therefore, accurate identification sites becomes emergently important. For above purpose, here computational predictor site named SRAMP established. To depict sequence...
Comprehensive databases of microRNA-disease associations are continuously demanded in biomedical researches. The recently launched version 3.0 Human MicroRNA Disease Database (HMDD v3.0) manually collects a significant number miRNA-disease association entries from literature. Comparing to HMDD v2.0, this new contains 2-fold more entries. Besides, the have been accurately classified based on literature-derived evidence code, which results six generalized categories (genetics, epigenetics,...
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety diseases. A knowledgebase with systematic collection and curation lncRNA-disease associations critically important for further examining their underlying molecular mechanisms. In 2013, we presented the first release LncRNADisease, representing database experimental supported associations. Here, describe an update database. The new developments LncRNADisease 2.0 include (i) over...
MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and are therefore important cellular components. As is true for protein-coding genes, transcription of miRNAs regulated by factors (TFs), an class regulators that act transcriptional level. The correct regulation TFs critical, increasing evidence indicates aberrant can cause phenotypic variations diseases. Therefore, a TF-miRNA database would be helpful understanding mechanisms which their contribution to In this...
Long noncoding RNAs (lncRNAs) represent a big category of RNA molecules, and increasing studies have shown that they play important roles in various critical biological processes. They show diversity functions through diverse mechanisms, among which regulating molecules is one the most popular ones. Given number lncRNAs, it becomes urgent to predict targets lncRNAs large scale for comprehensive understanding lncRNA action mechanisms. Although several methods been developed RNA–RNA...
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and play vital roles in various biological processes. It has been reported that aberrant regulation miRNAs was associated with the development progression diseases, but underlying mechanisms not fully deciphered. Here, we described our updated TransmiR v2.0 database for more comprehensive information about transcription factor (TF)-miRNA regulations. 3730 TF-miRNA regulations among 19 species from 1349...
There has been great interest in attempting to identify gene expression signatures that predict cancer survival. In this study a new algorithm is developed analyse datasets accurately classify both ER+ and ER− breast cancers into low- high-risk groups. Cancer patients are often overtreated because of failure low-risk patients. Thus far, no able successfully generate prognostic with high accuracy robustness order these paper, we an identifies markers using tumour microarrays focusing on...
The microbiota living in the human body has critical impacts on our health and disease, but a systems understanding of its relationships with disease remains limited. Here, we use large-scale text mining-based manually curated microbe–disease association data set to construct microbe-based network investigate between microbes genes, symptoms, chemical fragments drugs. We reveal that loops are significantly coherent. Microbe-based connections have strong overlaps those constructed by...
Abstract Various posttranslational modifications (PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states PTMs are frequently implicated human diseases. Therefore, an integral resource PTM–disease associations (PDAs) would be a great help for both academic research clinical use. In this work, we reported PTMD, well-curated database containing that associated with We manually collected 1950 known PDAs 749 proteins 23 types 275...
With the rapid accumulation of high-throughput microRNA (miRNA) expression profile, up-to-date resource for analyzing functional and disease associations miRNAs is increasingly demanded. We here describe updated server TAM 2.0 miRNA set enrichment analysis. Through manual curation over 9000 papers, a more than two-fold growth reference sets has been achieved in comparison with previous TAM, which covers 9945 1584 newly collected miRNA-disease miRNA-function associations, respectively....
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
MicroRNAs (miRNAs) are a class of important small non-coding RNAs with critical molecular functions in almost all biological processes, and thus, they play roles disease diagnosis therapy. Human MicroRNA Disease Database (HMDD) represents an comprehensive resource for biomedical researchers miRNA-related medicine. Here, we introduce HMDD v4.0, which curates 53530 miRNA-disease association entries from literatures. In comparison to v3.0 released five years ago, v4.0 contains 1.5 times more...
Abstract Systematic integration of lncRNA-disease associations is great importance for further understanding their underlying molecular mechanisms and exploring lncRNA-based biomarkers therapeutics. The database long non-coding RNA-associated diseases (LncRNADisease) designed the above purpose. Here, an updated version (LncRNADisease v3.0) has curated comprehensive lncRNA (including circRNA) disease from burgeoning literatures. LncRNADisease v3.0 exhibits over 2-fold increase in...
Article18 December 2007Open Access A map of human cancer signaling Qinghua Cui Computational Chemistry and Biology Group, Biotechnology Research Institute, National Council Canada, Montreal, QC, Canada Search for more papers by this author Yun Ma Department Biology, Tianjin Normal University, Tianjin, China Maria Jaramillo Receptor, Signaling Proteomics Hamza Bari Arif Awan Song Yang School Chemical Engineering, Simo Zhang Lixue Liu Meng Lu Maureen O'Connor-McCourt Enrico O Purisima Center...
Endothelial cells (ECs) respond to changes in mechanical forces, leading the modulation of signaling networks and cell function; an example is inhibition EC proliferation by steady laminar flow. MicroRNAs (miRs) are short noncoding 20–22 nucleotide RNAs that negatively regulate expression target genes at posttranscriptional level. This study demonstrates miRs involved flow regulation gene ECs. With use microRNA chip array, we found shear stress (12 dyn/cm 2 , 12 h) regulated many miRs,...
MicroRNAs (miRNAs) are small noncoding RNAs which play essential roles in many important biological processes. Therefore, their dysfunction is associated with a variety of human diseases, including cancer. Increasing evidence shows that miRNAs can act as oncogenes or tumor suppressors, and although there great interest research into these cancer-associated miRNAs, little known about them. In this study, we performed comprehensive analysis putative miRNA suppressors. We found suppressors...
Aims: Hydrogen sulfide (H2S) has a protective role in the pathogenesis of atherosclerosis by multiple pathways. Sirtuin-1 (SIRT1) is histone deacetylase, as an essential mediated longevity gene, and anti-atherogenic effect regulating acetylation some functional proteins. Whether SIRT1 involved protecting H2S its mechanism remains unclear. Results: In ApoE-knockout mice, treatment with donor (NaHS or GYY4137) reduced atherosclerotic plaque area, macrophage infiltration, aortic inflammation,...