A5031334632- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Glycosylation and Glycoproteins Research
- Influenza Virus Research Studies
- Microbial Community Ecology and Physiology
- Autophagy in Disease and Therapy
- Heavy metals in environment
- Single-cell and spatial transcriptomics
- Plant Physiology and Cultivation Studies
- Toxin Mechanisms and Immunotoxins
- Plant Disease Management Techniques
- Heavy Metal Exposure and Toxicity
- Gut microbiota and health
Southwest Jiaotong University
2015-2025
Huazhong University of Science and Technology
2021-2024
MRC University of Glasgow Centre for Virus Research
2023
Medical Research Council
2001-2023
Henan University
2022-2023
Cardiff University
2022
Zhejiang Chinese Medical University
2022
Nanjing Agricultural University
2022
Ministry of Agriculture and Rural Affairs
2021
Harbin Medical University
2021
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
Abstract Protein phosphorylation, catalyzed by protein kinases (PKs), is one of the most important post-translational modifications (PTMs), and involved in regulating almost all biological processes. Here, we report an updated server, Group-based Prediction System (GPS) 6.0, for prediction PK-specific phosphorylation sites (p-sites) eukaryotes. First, pre-trained a general model using penalized logistic regression (PLR), deep neural network (DNN), Light Gradient Boosting Machine (LightGMB)...
Abstract Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, harm caused by coronaviruses to world cannot be underestimated. Recently, a novel coronavirus (severe coronavirus‐2 [SARS‐CoV‐2]) initially found trigger human illness Wuhan City China 2019, has infected more than six million people worldwide 21 June 2020, and which been recognized as public health emergency international concern well. And virus spread 200 countries around world. However, effective drug not yet...
Knowledge of the mechanisms for regulating lifespan is advancing rapidly, but a complex phenotype and new features are likely to be identified. Here we reveal novel approach lifespan. Using genetic or pharmacological strategy lower rate sphingolipid synthesis, show that Saccharomyces cerevisiae cells live longer. The longer due in part reduction Sch9 protein kinase activity consequent chromosomal mutations rearrangements increased stress resistance. Longer also arises ways independent...
The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), offers comprehensive suite database resources to support global scientific community. Amidst unprecedented accumulation multi-omics data, CNCB-NGDC committed continually evolving and updating its core through big data archiving, integrative analysis value-added curation. Over past year, has expanded collaborations with international databases established new subcenters focusing on biodiversity,...
Abstract Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge large-language model (LLM), generative pre-trained transformer (GPT) 3.5, which interprets 10.2–13.8% of Drosophila genes known to regulate the 3 behaviors. We develop an instrument for simultaneous video tracking multiple moving objects, conduct genome-wide screen. have identified...
Abstract Small ubiquitin-like modifiers (SUMOs) are tiny but important protein regulators involved in orchestrating a broad spectrum of biological processes, either by covalently modifying substrates or noncovalently interacting with other proteins. Here, we report an updated server, GPS-SUMO 2.0, for the prediction SUMOylation sites and SUMO-interacting motifs (SIMs). For predictor training, adopted three machine learning algorithms, penalized logistic regression (PLR), deep neural network...
Abstract Recent high-throughput omics techniques have produced a large amount of biological data. Visualization big data is essential to answer wide range problems. As concise but comprehensive strategy, heatmap can analyze and visualize high-dimensional heterogeneous biomolecular expression in an attractive artwork. In 2014, we developed stand-alone software package, Heat map Illustrator (HemI 1.0), which implemented three clustering methods seven distance metrics for illustration. Here,...
Studies of aging and longevity are revealing how diseases that shorten life can be controlled to improve the quality lifespan itself. Two strategies under intense study accomplish these goals rapamycin treatment calorie restriction. New being discovered including one uses low-dose myriocin treatment. Myriocin inhibits first enzyme in sphingolipid synthesis all eukaryotes, we showed recently increases yeast at least part by down-regulating sphingolipid-controlled Pkh1/2-Sch9 (ortholog...
Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying physiological responses and adaptation to aneuploidy are not well understood. Deciphering these is important because associated with diseases, including intellectual disability cancer. Although tumors mammalian aneuploid cells, several cancer cell lines, show altered levels of sphingolipids, role sphingolipids in remains unknown. Here, we that ceramides long-chain bases, sphingolipid molecules slow...
Excessive free radicals and iron death lead to oxidative damage, which is one of the main causes aging diseases. In this field antioxidation, developing new, safe, efficient antioxidants research focus. Lactic acid bacteria (LAB) are natural with good antioxidant activity can regulate gastrointestinal microecological balance immunity. study, 15 LAB strains from fermented foods ("Jiangshui" pickles) or feces were evaluated in terms their attributes. Strains strong capacity preliminarily...
A novel coronavirus (SARS-CoV-2) that is initially found to trigger human severe respiratory illness in Wuhan City of China 2019, has killed 2,718 people by February 26, 2020, and which been recognized as a public health emergency international concern well. And the virus spread more than 38 countries around world. However, drug not yet officially licensed or approved treat SARS-Cov-2 infection. NSP12-NSP7-NSP8 complex SARS-CoV-2, essential for viral replication transcription, generally...
In a cavity quantum electrodynamics (QED) system, where atoms coherently interact with photons in cavity, the eigenstates of system are superposition states and photons, so-called dressed atoms. When two cavities connected by an optical fiber negligible loss, coherent coupling between gives rise to photonic normal modes. One these modes is fiber-dark mode, which delocalized distant cavities. Here we demonstrate setting coupled-cavities QED, nanofiber cavity-QED systems meter-long low-loss...
Virtual Exchange (VE) has emerged as a promising alternative to traditional physical exchange, experiencing exponential growth in recent years enhance students’ learning outcomes. However, the ways which VE can effectively and mutually benefit diverse student populations remain unclear. This study introduces specifically designed project utilizing “Zoom-Sandwiched Cross-Chapter Concept Map” model investigates its impact on college students enrolled an introductory-level course US China. The...
Objective: Staphylococcus aureus (S. aureus) has been one of the pathogenic bacteria for clinical infections, and there is an urgent need development novel anti-S. drugs. SecA a conserved essential protein in considered as ideal target development. Current screening inhibitors against focused on ATP-binding structural domain, which increases risk drug side effects, so strategy based non-ATP-binding domain was chosen this paper. Methods: A three-dimensional model S. SecA1N75 constructed,...
Droughts and floods have proven to be threats food security worldwide. This research used the standardized precipitation index (SPI) examine spatiotemporal characteristics of drought wet events from 1961 2020 in Yellow River basin (YRB). Grain yield data were combined assess how frequency affected agricultural system. The occurrence was greater than that wetness time, decreased, increased. Spatially, all provinces except Shanxi higher wetness. grain per unit area YRB generally highest...