Shaohua Fan
A5022155426- Genomics and Phylogenetic Studies
- Genomics and Rare Diseases
- Genetic diversity and population structure
- Fish Biology and Ecology Studies
- melanin and skin pigmentation
- Fish biology, ecology, and behavior
- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Computer Graphics and Visualization Techniques
- Skin Protection and Aging
- Genomic variations and chromosomal abnormalities
- Identification and Quantification in Food
- interferon and immune responses
- Fish Ecology and Management Studies
- Advanced Vision and Imaging
- RNA and protein synthesis mechanisms
- Biochemical Analysis and Sensing Techniques
- Hepatitis C virus research
- Ichthyology and Marine Biology
- Systemic Lupus Erythematosus Research
- Color Science and Applications
- Cancer Genomics and Diagnostics
- Race, Genetics, and Society
- Structural Behavior of Reinforced Concrete
- Metabolism and Genetic Disorders
Fudan University
2021-2025
State Key Laboratory of Genetic Engineering
2022-2025
Zhongshan Hospital
2025
University of Pennsylvania
2016-2024
Children's Hospital of Fudan University
2024
Jinan Central Hospital
2022-2024
Shandong First Medical University
2022-2024
Zhengzhou University
2024
Huashan Hospital
2024
University of Konstanz
2010-2016
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand molecular mechanisms underlying cichlid phenotypic diversity, we sequenced genomes transcriptomes five lineages African cichlids: Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; four members lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent Malawi), Pundamilia nyererei (very recent...
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage lobe-finned fish thought to have become extinct 70 million years ago. modern looks remarkably similar many its ancient relatives, and evolutionary proximity our own ancestors provides glimpse the that first walked on land. Here we report genome sequence African coelacanth, Latimeria chalumnae. Through phylogenomic analysis, conclude lungfish, not is closest relative tetrapods. Coelacanth protein-coding...
Ingo Braasch, John Postlethwait and colleagues report the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before duplication. Their data provide insights into evolution genes involved in immunity, mineralization development facilitate comparison cis-regulatory elements between humans. To connect human biology to fish biomedical models, we sequenced teleost duplication (TGD). The slowly evolving has conserved content size many entire chromosomes bony...
African genomics and skin color Skin varies among human populations is thought to be under selection, with light maximizing vitamin D production at higher latitudes dark providing UV protection in equatorial zones. To identify the genes that give rise palette of tones, Crawford et al. applied genome-wide analyses across diverse (see Perspective by Tang Barsh). Genetic variants were identified likely function phenotypes. Comparison model organisms verified a conserved MFSD12 pigmentation. A...
Seahorses have a specialized morphology that includes toothless tubular mouth, body covered with bony plates, male brood pouch, and the absence of caudal pelvic fins. Here we report sequencing de novo assembly genome tiger tail seahorse, Hippocampus comes. Comparative genomic analysis identifies higher protein nucleotide evolutionary rates in H. comes compared other teleost fish genomes. We identified an astacin metalloprotease gene family has undergone expansion is highly expressed pouch....
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to pangenome form, but populations of Asian ancestry are underrepresented. Here we present data the first phase Chinese Pangenome Consortium, including collection 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority ethnic groups. With average 30.65× high-fidelity long-read coverage, contiguity N50 more than 35.63 megabases total size 3.01 gigabases,...
Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. By integrating human population-level phenotypic and multi-omics data as well two humanized mouse models, demonstrate the causal roles SVs: one SV that emerges at common ancestor modern humans, Neanderthals, Denisovans GSDMD for bone mineral...
Abstract Crater lakes provide a natural laboratory to study speciation of cichlid fishes by ecological divergence. Up now, there has been dearth transcriptomic and genomic information that would aid in understanding the molecular basis phenotypic differentiation between young species. We used next‐generation sequencing (Roche 454 massively parallel pyrosequencing) characterize diversity expressed sequence tags ecologically divergent, endemic sympatric species from crater lake Apoyo,...
Africa is the origin of modern humans within past 300 thousand years. To infer complex demographic history African populations and adaptation to diverse environments, we sequenced genomes 92 individuals from 44 indigenous populations.
Abstract Next‐generation sequencing ( NGS ) techniques are now key tools in the detection of population genomic and gene expression differences a large array organisms. However, so far few studies have utilized such data for phylogenetic estimations. Here, we use obtained from genome‐wide restriction site‐associated DNA RAD (∼66000 SNPs) to estimate relationships among all 26 species swordtail platyfish (genus X iphophorus C entral A merica. Past studies, both sequence morphology‐based,...
Genomic DNA reference materials are widely recognized as essential for ensuring data quality in omics research. However, relying solely on datasets to evaluate the accuracy of variant calling results is incomplete, they limited benchmark regions. Therefore, it important develop that enable assessment detection performance across entire genome.
We introduce Group Motion Graphs, a data-driven animation technique for groups of discrete agents, such as flocks, herds, or small crowds. Graphs are conceptually similar to motion graphs constructed from motion-capture data, but have some important differences: we assume simulated motion; transition nodes found by clustering group configurations the input simulations: and clips join transitions explicitly via constrained simulation. built this way offer known bounds on trajectories that...
In response to the shortcomings of molecularly targeted drug delivery systems, this article designs a supramolecular self-assembled nanodrug system. The system uses polylactic-co-glycolic acid (PLGA) and polyethylene glycol (PEG) as main materials, through careful design optimization, achieves efficient loading stable release doxorubicin hydrochloride (Doxorubicin HCl). experimental results show that nano-drug has uniform particle size distribution (about 100-200nm), high efficiency good...