A5103112441- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Lung Cancer Diagnosis and Treatment
- Genomics and Rare Diseases
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- HVDC Systems and Fault Protection
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Congenital heart defects research
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Genomic variations and chromosomal abnormalities
- Obesity, Physical Activity, Diet
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Gene Regulatory Network Analysis
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
Nanjing Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to pangenome form, but populations of Asian ancestry are underrepresented. Here we present data the first phase Chinese Pangenome Consortium, including collection 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority ethnic groups. With average 30.65× high-fidelity long-read coverage, contiguity N50 more than 35.63 megabases total size 3.01 gigabases,...
Cardiogenesis is a tightly regulated dynamic process through continuum of differentiation and proliferation events. Key factors pathways governing this remain incompletely understood. Here, we investigate mice hearts from embryonic day 10.5 to postnatal week 8 dissect developmental changes in phosphoproteome-, proteome-, metabolome-, transcriptome-encompassing cardiogenesis cardiac maturation. We identify mitogen-activated protein kinases as core involved transcriptional regulation by...
Abstract Genome-wide association studies (GWAS) have identified over 50 lung cancer risk loci; however, the precise cellular context of these genetic mechanisms remains unclear due to limitations in bulk tissue eQTL analyses. Here, we present largest single-cell atlas human date, profiling 222 donors using multiplexed scRNA-seq. We 16,785 eQTLs across 17 cell types, with 90% sc-eQTLs and 59% eGene being cell-type-specific, fewer than 23% were detectable paired datasets. Integration GWAS for...
Rationale: The association between fine particulate matter (PM2.5) and lung cancer incidence in non-smokers (LCINS) remains inconsistent. Objectives: To investigate the long-term PM2.5 exposure LCINS a Chinese population to assess modifying effect of genetic factors. Methods: Time-dependent Cox proportional hazard models were employed evaluate ratios (HR) 95% confidence interval (CI) with risk LCINS-related mortality. polygenic score (PRS) was constructed further explore interactions...
Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case-control studies for CRC, including 223 pairs US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial 190 prospective Chinese cohort. explored serum metabolites related body mass index (BMI), constructed metabolomic signature of obesity, examined association...
Fatty acids (FAs) have emerged as significant contributors to tumorigenesis, yet prospective evidence regarding their specific effects on lung cancer risk remains scarce.
Early-onset lung cancer is rare with an increasing incidence rate. Although several genetic variants have been identified for it candidate gene approaches, no genome-wide association study (GWAS) has reported. In this study, a two-stage strategy was adopted: firstly we performed GWAS to identify associated early-onset nonsmall-cell (NSCLC) risk using 2556 cases (age ≤ 50 years) and 13,327 controls by logistic regression model. To further discriminate younger from older ones, took case-case...
Abstract N 6 ‐methyladenosine (m A) modification has been identified as one of the most important epigenetic regulation mechanisms in development human cancers. However, association between m A‐associated single‐nucleotide polymorphisms A‐SNPs) and lung cancer risk remains largely unknown. Here, we A‐SNPs examined these with 13,793 cases 14,027 controls. In silico functional annotation was used to identify causal target genes. Furthermore, methylated RNA immunoprecipitation quantitative...